Statistical analysis consistently demonstrated a highly significant increase in apoptosis in neuroblastoma cells compared with hDFs ( p < 0.001), though replicate data are not displayed.
Excerpts
The overall pooled effect was highly significant (Z = 8.77, p < 0.001).
Differences were considered non-significant (ns) when p > 0.05, significant (*) when p < 0.05, very significant (**) when p < 0.01, and highly significant (***) when p < 0.001.
Kaplan Meier analysis considering tumor size exceeding 800 mm 3 as an endpoint showed a highly significant difference between curves ( p = 0.001) ( Figure 6 A,B).
In parallel, there were also highly significant ( p < 0.001, mean difference 6.7, 95%CI =+ 5.6 + 7.8) changes in total physical activity levels.
In the Chi-square test, the OSCC tissue samples showed a highly significant upregulation of CD96 mRNA expression ( p < 0.001) and protein expression ( p = 0.005) compared to the healthy mucosa.
The findings of a lesion size larger than 10 mm had a highly significant effect on the outcome ( p < 0.001), with an odds ratio (OR) of 9.72 (95% CI: 2.97 to 31.86), indicating that for an enhancing lesion, having a size larger than 10 mm increases the odds of malignancy by nearly ten times.
Moreover, the linear-by-linear association was highly significant (33.832, p < 0.001), demonstrating a clear ordinal trend: as clinical severity increased (according to the Olsen score), the severity of honeycomb pattern disruption also intensified.
Statistical significance was defined as significant (* p value ≤ 0.05), very significant (** p value ≤ 0.01), and highly significant (*** p value ≤ 0.001). 5.
Tumor Subsite Tumor anatomic distribution showed a highly significant difference between NSND and SD patients ( p < 0.001).
These changes toward rurality are highly significant, as the p < 0.001 indicates that the counties with low employment and low education levels are geographically isolated, which probably restricts their access to economic and healthcare opportunities. 3.4.
The effect was highly significant in UACC-62, UACC-257, RPMI7951, and WM1366 cells ( p < 0.001), and significant in FB789 ( p < 0.01), confirming the specificity and efficacy of ASO-mediated silencing.
Subgroup analyses focusing on mid/distal tumor locations and cTNM stages II/III indicated a significant trend towards improved survival with NAC (all p < 0.001).
Statistical significance was defined as significant (* p -value ≤ 0.05), very significant (** p -value ≤ 0.01) and highly significant (*** p -value ≤ 0.001). 5.
Further, the Kaplan–Meier curves of the metastasis-free survival showed a highly significant worse clinical course for the high-risk group (log-rank test: p < 0.001), and we demonstrated superiority over other established risk factors.
The pooled OR from the random-effects model is 1.53, with a 95% CI of 1.107 to 1.945 and a highly significant p -value of <0.001.
This increase was highly significant ( p < 0.001) in seven out of eight pairs.
Kaplan–Meier analysis demonstrated a highly significant difference in overall survival among the geneClusters ( p < 0.001) ( Figure 4 C), indicating that this DEG-based secondary classification further refines outcome stratification beyond the initial senescence clusters.
Second, according to Figure 10 , a strong and highly significant positive correlation was identified between the number of lymph nodes examined and the number of lymph nodes invaded (rho = 0.65, p < 0.001; Figure 5 ).
[ 74 ] found that the prevalence of ER-negative breast cancer was higher in their diabetic patients compared with the non-diabetic group; however, although the small difference, 32.2% versus 30.6%, was statistically highly significant ( p < 0.001), this may have been affected beyond its biological influence by the large sample sizes.
With respect to potential biological prognostic factors, highly significant correlations of moderate magnitude were observed between sβ 2 m and serum soluble CD30, serum interleukin-10 and serum ferritin ( p < 0.001 but Spearman’s rho 0.333–0.455), as summarized in Table 2 .
Compared to the corresponding normal tissue, a highly significant expression ( p < 0.001) was found in eighteen tumor tissues, including bladder urothelial carcinomas (BLCA), invasive breast carcinoma (BC), cholangiocarcinomas (CHOL), colon adenocarcinoma (COAD), esophageal carcinomas (ESCA), glioblastoma multiforme (GBM), squamous cell carcinoma (SCC) of the hea
Significant differences in eGFR were observed after cycles 1 through 3, with highly significant reductions emerging from cycle 4 onward (all p < 0.001).
The narrow confidence interval and highly significant p -value ( p < 0.001) further support the reliability and clinical relevance of this finding.
The observed PDT effect after illumination was curcumin dose-dependent and highly significant ( p < 0.001).