Excerpts

Acute toxicity during treatment may be significant with fatigue, nausea, vomiting, dyspepsia, or gastritis and may be particularly pronounced in the adjuvant setting after more extensive gastrectomies.

However, this difference remained highly significant for patients with Medicaid or those without insurance at diagnosis.

This observation is quite significant, since miR-155-5p plays a decisive role in both normal B-cell development and Β-CLL progression, as it has been thoroughly analyzed above.

Multivariable regression analysis showed a trend for significance for previous breast surgery with regards to the per-patient SLN magnetic detection rate at >0 magnetic tracer signal cut-off (b = 5.435, 95% confidence interval (CI) 0.925, 31.935; p = 0.061), and significance for previous breast surgery at >20 cut-off (b = 6.957, 95% CI 1.552, 31.192, p = 0.011).

Conversely, PBMCs from all 7 tested canine lymphoma patients showed highly significant response to atezolizumab ( Figure 4 C), whereas avelumab was again ineffective ( Figure 4 D).

Therefore, there may be significant heterogeneity across patients in terms of which resistance mechanisms are at play and how they emerge and are maintained.

In the last decade, 44% of the ASCT recipients were at least 60 years of age according to data from CIBMTR, which is an encouraging trend [ 15 ].

Our preliminary data showed a trend towards increased YAP/TAZ protein expression in JAM-A overexpressing breast cancer cells ( Figure S18 ); potentially suggesting a mechanism to account for increased β-catenin expression and transcriptional activity in the JAM-overexpressing tumorigenic cellular model.

In particular, AZD-1775 response formed a highly significant (FDR = 5.6 × 10 −46 ) association with TP53 mutational status in breast cancer patients ( Figure 2 B).

In contrast to solid cancers, leukemia and non-Hodgkin’s lymphoma cases showed a trend toward an improved 30-day mortality but without statistical significance. 4.

Growth dynamic showed only borderline significance in the small subset, while the diffuse infiltration score and its development were no longer a significant risk factors.

While correlations of the volume and speed of growth of the FLs to the existence/appearance of OL were highly significant, the discriminative ability of both parameters was limited (Aera under the receiver operating curve (ROC AUC) 0.622 and 0.575, respectively).

By contrast, body mass index (BMI) showed a trend to be a favorable marker of survival with a HR of 0.97 (CI95%: 0.926–1.01).

39 of the 44 DNA repair proteins analyzed showed mostly highly significant increased mRNA expression in samples with a high CIN70 score compared to samples with a low CIN70 score; only ATM showed a nonsignificant increase at a high CIN70 score.

Unlike the PCS, the MCS does not show a clear trend with age.

Another interesting finding was the association of the ATG5 SNP with CRC risk that remained only marginally significant after multiple testing corrections.

Cell death became highly significant only upon treatment with 20 μM Tam, which reduced the culture viability by about 50%.

Correlations, while highly significant, were of weak to moderate strength, likely due to the small participant cohort and, in the case of the distress thermometer, the lack of granularity of the outcome measure.

Even being not significant due to the small number of cases in the ATIP1 high cohort, ATIP1 high glioma patients showed a slight trend towards a prolongated median survival (median survival not reached so far) compared to ATIP1 intermediate/low patients (48 months) ( Figure S2a ).

While the various tested combinations of MAPK associated kinases indicated mostly highly significant correlation with overall survival Figure S4B,D,F,H ), the mRNA analyses revealed an inconsistent expression pattern depending from kinase to kinase, reflecting the identified differences between SAS and UTSCC15 cell lines ( Figures S2B and S4A,C,E,G ).

While pathway activity scores between quadrant samples of a single block, and between blocks of one PT showed highly significant correlations, correlations decreased between PT and LN metastases and significance was lost.

Upon comparison of all CAFs with all NFs, the two proteins αSMA and CAV1 showed a clear trend towards increased abundance in CAFs, while CD90 was significantly enriched in NFs.

Moreover, a clear trend is present in control-FREEC, with a substantial overestimation for low-medium true values and an underestimation for high values (intercept = 0.72).

Interestingly, maximal classification accuracy depended on the number of PCs used for classification, showing an increasing trend towards a specific number of PCs ( Figure 4 ).

These differences in TNM stage were highly significant.