Excerpts

In the peritumoral area, higher frequencies of CD3 + or CD8 + T cells were linked to significantly longer DFS (p=0.0097), while an increased density of PD-1 + CD8 + T cells showed a strong trend towards a positive impact on DFS (p=0.06) ( Figure 5B ).

Difference between these two subgroups was close to significance (Chi2 = 3.41, df = 1 (P = 0.06), I2 = 70.7%).

Low-dose tofacitinib significantly extended survival of ALS mice compared to untreated control ALS mice in the intervention (6.2 day increase; p = 0.02) and cycle (7.3 day increase, p = 0.004) regimens and showed a trend towards improvement in the prevention regimen (p = 0.06; Figure 1B ).

However, cadonilimab showed a trend toward PFS improvement in this subgroup (HR = 0.65, 95%CI = 0.42–1.03, p = 0.06) and reached significance for PFS in the metastatic subgroup (HR = 0.70, 95%CI = 0.54–0.92, p < 0.05).

Results While not quite statistically significant, a higher proportion of HLA-DQA1*01:02 carriers receiving OIT in IMPACT were desensitized (93%) compared to non-carriers (78%); odds ratio (OR)=5.74 (p=0.06).

Associations between NR3C1 DNA methylation and peritraumatic distress, perceived stress, and depression Results in the lower panel of Table 2 show that pregnant women who were depressed had a higher NR3C1 DNA methylation level than women who were not depressed with a marginal significance level (t = −2.13, p = 0.06).

The results showed that high expression of ALOX15 was significantly positively associated with larger tumor size (p = 0.013) and vascular invasion (p = 0.043) and correlated with advanced tumor stage with borderline significance (p = 0.060) ( Table 1 ), suggesting that ALOX15 is related to the malignant behavior of BC.

Borderline significance of sTNFRSF3 (p=0.06) were demonstrated, Figure 2 .

Compared to MN, they showed comparatively lower 24-hour proteinuria excretion but with marginal significance (3.96 versus 4.63 g/d, P =0.060) and presented significantly less frequency of nephrotic syndrome (47.45% versus 72%, P <0.001).

Also, two factors, number of relapses and CRS grade, were shown to have significant relations to MRD-negative CR ( p < 0.05, Tables 2 , 3 ), while the relation between CRS grade and CR was marginally significant ( p = 0.06, Table 3 ).

Semiquantitative analysis indicated that the CD11b + macrophage population was higher in the UUO KLN than the contralateral KLN; although the comparison did not quite reach significance (p=0.06) at Day 7, a significant increase (p<0.01) was observed at Day 14 ( Figure 2B ).

By contrast, the minor allele (T) of rs11203367 conferred a borderline significant increase in OR for anti-CCP-positive RA in HLA-DRB1*04 -positive subjects (p=0.06, Table 3 ), as visualized in Figure 2B (light blue bars for carriers versus dark blue bars for non-carriers).

Of note, GLILD patients presented a borderline significant expansion of CD3CD8CD57+ large T granular lymphocytes ( p = 0.06), becoming significant when pooling together uILD and GLILD subgroups ( p < 0.01) ( Supplementary Table 1 ).

Post-hoc analysis revealed that UAB-la12 was associated with a statistical trend for a 22% (p = 0.06) decrease in the PSQI ( Figure 3 ).

104 mg/L, P < 0.001), translating into borderline significant superior survival ( P = 0.060 for rs1520220) and reduced treatment-related mortality ( P = 0.050 for rs978458).

Validation in SLE, RA, IBD, and JIA By comparing the TPM values of CD160 and CD58 from four RNA-seq datasets including SLE ( GSE112087 ), RA ( GSE117769 ), IBD (GSE112057IBD), and JIA (GSE112057JIA), we found that the aberrant expression of CD160 was statistically significant in SLE ( P = 0.0006), IBD ( P < 0.0001) and JIA ( P = 0.0005), and was marginally significant in RA ( P = 0.06) ( Figure 3 ).

Similarly, in the subgroup of patients with moderate atopic dermatitis defined as baseline IGA = 3, the Nu0.5 group showed a borderline significant decrease in IGA score from baseline (-16.7%, 95% CI: -31.3% to -2.0%, p = 0.06) ( Figure 2F ).

Furthermore, although the module-trait correlations in WGCNA were only marginally significant ( P = 0.06 and P = 0.07), downstream analyses, such as functional enrichment and immune cell association, strongly supported the relevance of these modules.

However, in the under 30-year age group, the G-allele of rs6478108 showed a strong trend toward association with T1R (OR = 2.08, p = 0.06; Table 2 ; Figure 2 ).

The increased spleen masses were statistically significant (n=3; p=0.009) whereas increases in length were near significance (n=3; p=0.060).

Although the confidence intervals for both treatments included 1, cadonilimab had a strong trend toward benefit in PFS (HR = 0.65, 95%CI = 0.42–1.03), where the upper limit approached significance ( p = 0.060) compared with pembrolizumab, which did not show a clear benefit in this subgroup (HR ~ 1).

Lastly, in the differential between ANA- SLE and AHV ( Figure 2F ), TC4d (AUC: 0.75) significantly outperformed anti-Smith (0.42, p < 0.01) and nearly reached significance for superior performance against anti-dsDNA (0.51, p = 0.06) and C3 (0.50, p = 0.05).

Notably, even patients who did not undergo transplantation showed a trend toward improved 4-year OS (21% vs. 16%, P = 0.06) ( 4 ).

TLG, included in two studies, showed a trend toward significance but fell short of the required threshold (HR = 3.68, 95% CI: 0.95–14.28, p = 0.060; I2 = 34.8%, Supplementary Figure S26B ; sensitivity analysis in Supplementary Figure S27B ).

Only LV showed a trend towards significance (AUC = 0.602; p = 0.060).