Excerpts

Goblet cells were significantly increased in BALB/c mice and showed a trend for increase in C57BL/6 mice after Alt treatment compared to PBS ( Figures 2E–I ).

CD8 + T central memory cells (CD8 + T CM ) showed a trend that did not quite reach statistical significance after Benjamini-Hochberg correction (FDR=0.11) ( Figure 6F ).

GO Analysis of TO-GCN After SARS-CoV-2 Infection The genes with peak gene expression at the first time point and a decreasing trend over time were defined as the initial node of TO-GCN.

This may be significant because loss of Trem2 has been shown to increase IFN-I signaling ( 97 ).

Of all markers tested the lymph node homing receptor CCR7 and CD15s (sialyl lewis x, expressed by Tregs in sarcoidosis) were lower in MulTreg, whilst gut homing integrin beta 7 (β 7 ) showed a trend for increased expression in MulTreg according to both MFI and frequency ( Figures 2G–I and S2C ).

Whilst both cell products showed a clear trend towards inhibition of IFNγ, TNFα and IL-17A in Flu-HA responses this was only significant in MulTreg co-cultures, however, no difference was seen in inhibition of IL-13 ( Figure 3F ).

The data showed that T-bet and Rorγt had an increasing trend at the onset of gut aGVHD, but PLZF did not demonstrate this trend ( Figure 5B and Supplementary Figure 5B ).

Il10 -/- mice showed a trend towards greater IFNγ production compared to B6 mice after both polyclonal stimulation ( Figures 4G, H ) and more strikingly directly ex vivo ( Figures 4I, J ).

There was a clear trend in differences between BLXA 4 and the no-rinse group, however, they were not statistically significant ( P =0.299 and P =0.111).

Combined urine complement products could increase the predictive ability compared with crescents alone from 0.904 to 0.944 ( p = 0.062) with borderline significance.

Similar results can be observed with the normal samples, although due to a very small sample size, the p -values were slightly significant, especially for the diversity measure ( Figures 2A, B ).

Both patients with chikungunya and with OAFD had an increasing trend in the levels of CXCL9 over time.

On the other hand, patients with chikungunya presented a decreasing trend in the levels of CXCL8, CCL2, CCL5, CXCL10, and IL-6 after 1 or 2-3 DPSO, but patients with OAFD did not follow this pattern.

PGD in the lung allograft was associated with an increase in the epigenetic age, and older methylation age showed a trend toward poorer outcomes.

In addition, Pan-Gyn analysis confirmed that a positive trend increases the risk of C1 to C5 ( Figure 4A ).

However, while this differential expression was highly significant in milk, it was only nominally changed in the plasma samples.

It is noteworthy that we detected an interesting trend in protein expression and/or PTMs associated with the adaptive and innate immune response.

Identification of Potential Small Molecule Drugs According to CMAP analysis, 10 small molecule drugs with highly significant correlations are listed in Table 3 .

This could promote hIgA1-sCD89 complex formation leading to deposits in the kidney, as suggested by an observed trend of increased hIgA1 glomerular deposits in P-mice as compared to NP-mice.

Diversity changes between the two groups (α -diversity) using three different indices also showed a trend towards age associated decrease in the Shannon index ( Figure 2B ) and increases in Chao1 ( Figure 2C ) and Simpson ( Figure 2D ) indices.

The analysis revealed that mice treated with berberine as an adjunct significantly reduced CXCL-10 ( Figure 5A ), while there was a decreasing trend towards IL-1β ( Figure 5B ) and CCL3 levels ( Figure 5C ) when compared to antibiotics alone.

The MacC2 cluster showed an increasing trend towards GC progression and mainly participated in apoptotic signaling pathways.

In addition, hydroxysteroid 11-beta dehydrogenase 1 and 2 ( Hsd11b1 and 2 ), heme oxygenase 1 ( Hmox ), and galectin-1 ( Gal-1 ) showed a trend toward increased expression in GRnegCD11c placentas, but did not reach levels of significance.

A direct comparison of the CD8 + T-cell response against E1 from Ii-E1E2E6E7 and E1E2E6E7 (Mann-Whitney rank-sum) revealed a p-value of 0.06, which is not strictly significant, but strongly indicates a tendency of Ii improving the magnitude of CD8 + T-cells against E1.

While tumors from Slit2-treated mice only showed a trend in decrease in the M2 macrophage population (data not shown), M1 macrophages identified as CD45+F4/80+CD38+ cells were significantly more abundant in mice with Slit2-treated tumors compared to PBS-treated tumors (71 ± 20 vs. 188 ± 81.4 cells in 20,000 events, n = 4, *p < 0.05) ( Figure 1B ).