Excerpts

The determination coefficient (for EE, R 2 = 0.9627; for size, R 2 = 0.9823) showed by ANOVA of the quadratic regression model, indicating that the model was highly significant and adequate for prediction within the range of experimental variables.

There is a clear trend for enhanced activity with the acetoxy groups as compared to the hydroxyl moiety when derivatives 1a – 8a and 1b – 8b are studied (see Table 1 and Table 2 ).

Other compounds showed only minor, statistically insignificant variation or even a decreasing trend in the case of octanal.

Some of the compounds with a higher load on PC1 were methyl ketones (3-methyl-2-pentanone and 3-methyl-2-butanone) and α-diketones (e.g., 2,3-pentanedione and 2,3-butanedione), meaning that these compounds showed a trend towards increasing their levels throughout hydrolysis time.

Since results of radioluminography narrowly missed significance, we decided to divide mice into two groups according to the sum of their tumor volumes and the median tumor volume sum of all mice (A375 pIRES + A375-EphB4 </> 1582.3 mm 3 ).

Total administered activities ranged from 37–148 kBq/kg and it was found that baseline peripheral blast count is a highly significant predictor of objective response [ 84 ].

However, when the ethanol concentration continued to increase from 40% to 80%, a decreasing trend was observed in the TEAC value.

Dietary exposure to benzopyrones is quite significant, as these compounds are found in fruits, vegetables, seeds, nuts, and higher plants.

These results demonstrate clearly that, although micelles are good at presenting epitopes to cells in culture, there may be significant issues related to their use in vivo.

p value less than 0.05 was considered significant and P value less than 0.01 was considered highly significant in all cases.

In all cases, p < 0.05 was considered significant, and p < 0.01 was considered as highly significant. 5.

According to the data in Table 2 , the model F -value of 76.8 and p < 0.0001 implied that the model was highly significant.

[ 35 ] found an increasing trend of skin tannins with irrigation.

This observation was further strengthened by a highly significant positive correlation (Pearson’s correlation coefficient 0.90) between Ψ d at veraison and harvest and seed TT at harvest in 2012 ( Supplemental Table S2 ).

Statistical analysis showed highly significant differences in these results ( Table S1a,b ).

The regression models were highly significant ( p 1 < 0.01, p 2 < 0.01), while the lack-of-fit tests were not significant ( p 1 = 0.1771 > 0.05, p 2 = 0.2737 > 0.05).

As it can be seen in Table 3 , an increasing trend in the rotational barrier is observed, with an increase of the distance between the indolylic and the boronic moiety.

We also speculated that there may be significant differences between the pharmacokinetic profiles at high (toxic) dosage and low (therapeutic) dosages, which probably provides some clues of the toxic metabolites.

Meanwhile, variance analysis indicated that the combination of the FCT penetration enhancement method and the CPE method had beneficial effects in enhancing skin penetration: the significance level of the CPE method was 0.0004, which was lower than 0.001, meaning the difference was markedly significant; the significance level of the FCT was also below 0.0001 and its difference markedly significant.

Experimental results from entries 7–9 in Table 1 present a decreasing trend of the trans/cis ratios without obvious difference between C -2-nitrophenylimine 2a and C -3- and 4-nitrophenylimines 2b and 2c , revealing that the ortho -nitro effect does not exist in the sulfa-Staudinger cycloadditions involving other alkanesulfonyl chlorides, such as phenylmethanesulfonyl chloride ( 1c ).

There is a significant trend nowadays with regard to utilising products derived from natural molecules, such as vegetable oil, which is due to the lower cost and the fact that the source is renewable.

In addition, the correlation between m logk values at 22 °C and 37 °C for PFP becomes highly significant (r = 0.938).

Statistical significant difference was preformed using a Student’s t -test, and p < 0.05 and p < 0.001 were considered statistically significant and highly significant, respectively. 4.

If the ultrasonication extraction time continued increasing from 45 min to 75 min, the antioxidant ability of the GMBC extraction showed a decreasing trend.

The p values < 0.05 (*) were considered significant, p values < 0.01 (**) and p < 0.001 (***) were considered highly significant. 4.