Excerpts

Combination Therapy Combination therapy is an important trend in the development of platinum anticancer agents and for bypassing of resistance to Cisplatin derivatives [ 55 ].

Multiple comparison (LSD-T test) was used for cell inhibition rate data, * means p < 0.05, significant; ** means p < 0.01, very significant; *** means p < 0.001, extremely significant.

For μ S 1 , the variation of the C^N and N^N ligands do not show a clear trend.

The emission of nitrous oxide for this sample showed an increasing trend within 150–300 °C, while above 350 °C N 2 O was almost absent in the post-reaction gas mixture.

The F value of multiple regression equation models was 82.43 ( p < 0.0001), indicating that the change in response value caused by the change in independent variable was extremely significant in this model.

An obvious trend in the values of E (2) listed in the table is the higher values for the corresponding donor–acceptor interactions in [(C6H5)2Sn(L)2] compared to [(C6H5)2Sn(L)2] .

On the other hand, relatively less reduction in particle size and almost insignificant morphology shift from bulky to flattened has been noticed for both wet ball milled and rotator mixed composite powders ( Figure 2 c,d).

Irrigation treatments 75% of the plant water requirement and especially full irrigation had the highest RWC of the leaf, and their differences with the other two irrigation treatments were quite significant ( Table 3 ).

It is remarkable, however, that even the accumulated aldehyde product × reaction time, which should discount this effect, continues to show a highly significant negative correlation with time.

Furthermore, confocal fluorescence images of activated myofibroblasts [stained in green with α-Smooth Muscle Actin (α-SMA) antibody in Figure 1 D] showed a statistically highly significant reduction in adhesion after 24 h on PEG-coated PI vs.

Herein, this exchange interaction may be significant but weaker than the exchange interaction between copper centers through the bridging phenoxide oxygen atom and chloride atoms and also compared with direct interactions between copper centers and N-oxide moieties.

In addition, under different rhythm conditions, the number and content of floral components showed a trend of first increasing and then decreasing; this was the case with lily [ 22 ] and Osmanthus [ 23 ].

There was a decreasing trend in linalool and an increasing trend in linalyl acetate content in lavandin, with an increase in drying duration up to 72 h; while in lavender, no regular trend was observed in linalool and linalyl acetate content.

Introduction A notable trend in modern medicinal and organic chemistry is the expansion of the structural diversity of non-planar scaffolds used for drug design purposes [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ].

In addition, there is an increasing trend in the number of M. alba research publications since 2001 ( https://link.lens.org/3k1hpsF0pmc , accessed on 12 January 2022).

We find a clear trend that the torsional barrier of the o-isomer is largest.

In combination with Table 7 , the interaction between AC and AB was extremely significant, whereas the interaction of BC was less than that of the two former combinations.

Significant differences between data points were classified as * p ≤ 0.05 (significant), ** p ≤ 0.01 (very significant), and *** p ≤ 0.001 (highly significant).

Nowadays, there is growing evidence that inosine can regulate inflammatory processes and neuronal growth properties that might be significant for neurodegenerative disorders [ 4 ].

The optimization of UAE parameters synchronously is extremely significant for predicting the extraction efficiency of eleven compounds.

The content of senkyunolide A decreased by 0.0525% in September; the other three compounds showed an increasing trend from June to October, entered a rapid accumulation period in September and reached the maximum value in October.

It can be clearly observed from Figure 12 a that the methane conversion rate demonstrates an increasing trend during the initial reaction stage of less than 130 min, implying the existence of an induction period for the MDA reaction during which active site molybdenum carbide species (Mo 2 C or MoO x C y ) are generated [ 50 ].

With the increase in the Bis-GMA:TEGDMA ratio of the pure resin, the flexural strength showed a trend of first increasing and then decreasing, as is clearly shown in Figure 6 .

A mutant to 412A has a mutation in isoniazid inducible gene iniB , which is involved in cell wall synthesis [ 57 ], while moaC3 (mutant to 412A) is part of the Molybdenum cofactor (Moco) biosynthesis pathway, which may be significant to pathogenesis [ 58 ].

An interesting trend was observed with the types of substituents on 1-phenyl-3-(4-phenyl)-4-formyl-1 H -substituted pyrazoles 31 and primary aromatic amines 32 .