Excerpts

This correlation was highly significant, far higher than the maximum correlation observed in randomized comparisons (empirical P < 0.0001; N = 10,000 bootstraps, R max = 0.03, see Methods).

For highly significant results where the exact value does not further impact scientific interpretation, p < 0.0001 is reported.

In spite of some discrepancies, as mentioned earlier, the correlation between these two parameters was highly significant (Pearson correlation coefficient, r = 0.8104, p < 0.0001) (Fig. 8 ).

This is a highly significant difference compared to metagenomes from individuals from other countries from which bacteroidetocin B was detected in 1.9–6% of metagenomes ( P < 0.0001).

In contrast, PD-1 blockade resulted in highly significant tumor growth delay ( p < 0.0001) in all mice bearing Nedd8 KO EO771 tumors (Fig. 6b ).

2 ) independent hairpin sequences had the same effect, each showing a highly significant reduction in cell viability upon treatment with 1 μM PD0325901 compared with DMSO treatment (two-sided t -test, P <0.0001, Fig. 1f ).

The highly significant correlation ( r =0.81, n =59, P <0.0001) between the Qamdo and regional residual series indicates the representativeness of the station record for larger spatial scales.

In contrast, the relationship between the human and sloth SPDs is positive and highly significant ( r s = 0.35, P < 0.0001), suggesting those populations fluctuated together from extrinsic factors.

The difference between the vaccine and control group at D28 is highly significant ( P <0.0001).

A two-way mixed-design ANOVA with the fixed factors of ‘electrode group’ and ‘recalled category’ and the random factors of ‘patient’ and ‘electrode’ (see Methods section for further details), revealed a highly significant interaction (F(1,63) = 17.69, p < 0.0001), indicating that each group of electrodes increased its HFB amplitude when the patients tried to recall images from its preferred category (Fig. 3a ).

Both the model based on Ad26.COV2.S and the model based on all vaccine candidates have highly significant slopes ( p < 0.0001) in the nose.

A linear regression analysis showed a very good correlation ( R 2 = 0.924) between the HrOr263 hydrocarbon responses in the ab3A and ab2A neurons, which was highly significant ( p < 0.0001).

Measuring the area under the curve (AUC) for mice proceeding to PID17 (PID3-PID17) ( n = 31) demonstrated a highly significant reduction in IFU in CTH522/CAF®01 vaccinated mice compared to control mice (Mann–Whitney U test, p < 0.0001) (Fig. 6f ).

Individually, HiFiCas9 treatment had a highly significant impact on viability (F (1, 12) = 69.55, p < 0.0001), accounting for 72.96% of the total variance.

Across all genomes, ERs were markedly closer in GC content to their host chromosomes than to unrelated chromosomes (median matched GC difference was 3.0%, compared to 10.9% for unmatched pairs), a difference that was highly significant ( p < 1 × 10−4) and associated with a large effect size (Cliff’s δ = −0.63).

En masse , there were highly significant differences between the mutation spectra before and after chemotherapy ( P <0.0001, χ 2 test, Supplementary Fig. 10 ).

The associations of ap2-g and gexp-5 transcript abundance with gametocyte production remained highly significant after adjustment for gametocyte density at the time of measurement ( p < 0.0001).

ns, p > 0.05 , not significant; p ≤ 0.05 , significant; p ≤ 0.01 , very significant; p ≤ 0.001 , highly significant; p ≤ 0.0001 , extremely significant.

Highly significant increases of plasma NfL were observed in all cognitively impaired and atypical parkinsonian groups as compared to PD ( P < 0.0001).

The linear correlations of L ↓ and K ↓ with T are highly significant ( p < 0.0001) for all the five reanalysis products.

Among the 12 loci associated with MG in the European meta GWAS, we identified nominally significant associations with same directional effects in the CTLA4 at 2q33 (rs231779, OR = 1.17, P = 1.0 × 10 −4 ), FAM76B at chromosome 11q21 (rs4409785, OR = 1.17, P = 0.030), and TNFRSF11A regions at 18q21 (rs7239261, OR = 1.14, P = 1.3 × 10 −3 ) in Japanese (Supplementary Table 2 ).

This distribution of alternative and constitutive pG4 genes for each UTR context was found to be highly significant through permutation testing ( P value < 0.0001 for 5′ and 3′ UTRs).

The difference in the survival rates between genotypes is highly significant with values of P < 0.0001.

6c ) Stratified by 30-day survival, we found a highly significant correlation between LRT neutrophil elastase and galectin-3 in survivors only (Fig. 6d, r = 0.54, p < 0.0001), an effect that was also driven primarily by patients with ARDS, as well as patients classified to the hypoinflammatory subphenotype (Fig. 6e–f ).

The model was highly significant ( P < 0.0001) and showed an improved R 2 m of 0.3180 (Fig. 4 , right; Supplementary Table 6a ), supporting an immunometabolic contribution to clinical severity within EBV-naïve/low participants.