Excerpts

Fig 5 panels A7, B8 and C8 demonstrate a highly significant, relative accumulation of NUP153 signals over chromosomes (classes 2–7) as compared to a relative depletion in the cytoplasm (represented by class 1).

Results Summary of sequencing data Our aim in this study was to determine the genetic variation in EBV genomes based on alignment to the two EBV strains, EBV-1 and EBV-2, and to assess genetic differences that may be significant to EBV pathogenesis.

integrase strand transfer inhibitors showed a trend toward a better effect of InSTI on virological response at week 48.

Even so, there was a strong trend toward insulin sensitivity prior to changes in weight (data not shown), implying intrinsic effects independent of weight loss.

Density was highly variable across regions, and displayed a decreasing trend from west to east.

The negative dataset was highly significant with a NES of- 1.44, and contained a core 365 genes that are negatively regulated by PTH in both the cell model and the bone tubes.

The positive enrichment did not quite reach significance.

The serum C-P levels show a decreasing trend after administration of chromium malate.

More than 50% ASC possessed either one of these two mutations and 42% ASC possessed both; 2) the frequency of four mutations (1485T, 1631T, 1762T, and 1764A) showed an increasing trend accompanied with the disease progression though the changes among groups were not significant (Jonckheere-Terpstra trend test, P > 0.05); and 3) ratios of 4 mutations (1383C, 1479C, 1479T, and 1719T) fluctuated among different disease phases.

Also, miR-409-5p showed a trend for down-regulation, while miR-410 did not significantly change.

While an overall trend of a one-to-two order decrease in magnitude in biofilm biovolume was observed in the high millimolar range, at the low millimolar range, there was a concentration that supported a modest increase in biofilm biovolume.

The biases for all NHP were smaller and less likely to be significant when reaching for the target.

The demographic history of the segment B of the IBDV genome for non-vvIBDV lineage, showed a trend toward a decrease in genetic diversity, possibly generated by the introduction of effective vaccination programs against classical and low virulent strains from early stages of the discovery of the disease [ 67 , 68 ].

Although these variants also resulted to be nominally significant when analysing the other chips, they lost their significance after adjusting for multiple testing (see Table 3 ).

The mean 1HPG values showed a decreasing trend in both treatment groups.

In some cases, the sample size was not sufficient, but there may be significant interethnic differences in the effect sizes at several loci; therefore, it is important to evaluate the effect of each locus in different ethnic groups [ 18 , 27 ].

We detected a positive trend between geographic distance and genetic differentiation between nest aggregations.

Discussion There is an increasing trend of conducting economic evaluations for the purpose of informing resource allocation decision-making in LMICs [ 39 , 40 ], driven largely by increased investment in this kind of policy research by major global health players such as BMGF, GAVI alliance, and the World Health Organization.

When we restricted our analyses to the top half of the ordinal rank distribution (ranks 1 through 8, n = 47, because lower ranking males rarely sire offspring) [ 16 ], we found a marginally significant linear relationship between dominance rank and length-for-age that explained ~9% of the variance in dominance rank: Dominance rank = (-1.59*length-for-age) + 3.33, F 1,45 = 4.510, R 2 = 0.091, p <0.05 ( Fig 3 ).

Clay content and indaziflam showed a negative trend, however a non-significant correlation was obtained.

Indaziflam and organic matter content showed a positive trend in this study, however no significant correlation was obtained.

A model using this combined SDRR variable as a predictor of neuroticism, using the same covariates as above gave a highly significant effect.

Results of a post-hoc linear regression analysis showed a trend of higher HAI response following the boost in the younger age stratum, although the difference was only statistically significant for A/California/07/2009 (H1N1) [HAI 2.3 times higher (95% CI 1.5, 3.4); p = 0.0001], and B/Wisconsin/1/2010 [HAI 1.5 times higher (95% CI 1.0, 3.4); p = 0.046].

However, results derived from the model predicted that large regions in the Atlantic domain might have experience increases in the development rate of up to 60%-80% and a more than 80% increase in the survival rates during developing and questing stages, which could be driven by a pronounced trend in temperature increase in the last 20–30 years [ 54 – 56 ].

*p<0.05 represented significance; **p≤0.01 and ***p≤0.001 were interpreted to be highly significant.