Barely Significant

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During the period 1990–2021, ASIR, ASMR and ASDR declined in most of the 204 countries and territories in the world, with China showing the most significant downward trend, with the largest decline in ASIR, ASMR, and ASDR, and the Republic of Korea showing a significant decline, however, there are still about one-tenth countries and territories around the world, such as Turkmenistan, Zimbabwe, Georgia and Lesotho, also show an increasing trend ( Fig 4 ).
Although no obvious acute inflammatory response was noted, these mice still developed chronic liver disease and hepatic fibrogenesis as demonstrated by increased ground glass-like hepatocytes, an increasing trend of collagen deposition and upregulated fibrosis markers, including type I collagen, type III collagen, tissue inhibitor of metalloproteinase (TIMP), and transforming growth factor-β1(TGF-β1).