Excerpts

Survival analysis of the BRCA1 adequate and deficient groups did show an interesting trend with the adequate tumors showing a marginal trend towards better prognosis although this was not significant statistically ( S4A Fig ) due to limited numbers.

To visualize the signal data obtained from metabolites in vivo and endogenous biomolecules in vitro , analysis was performed using linear scatter plots, which revealed a highly significant and reliable correlation ( Fig 7A and 7B ).

However, vildagliptin was suggested to have a lower risk of CV disease with borderline significance (OR 0.82, 95% CI 0.68 to 0.99), which is consistent with the results from pooled data of 25 phase 3 trials assessing cardio-cerebrovascular safety of vildagliptin [ 26 ].

Overall, incretin-based therapies showed a trend towards lower risk of cardiovascular disease compared to placebo or other antihyperglycemic agents, although the difference was not statistically significant.

In Italy, HF causes about 200,000 hospitalizations per year (88% among people aged > 65 years) with an increasing trend [ 3 ].

In a sensitivity analysis excluding patients died the day of admission, patients being 85 years and older or admitted to hospitals with less than 3000 cases/year we found a positive trend for revascularization when admitted to a medium or high-volume hospital compared to cases first hospitalized in a small hospital.

Discussion Stress Intensity and Segregation for Sodicity Tolerance in the RILs Analysis of variance revealed highly significant variation among the RILs for all the nine traits under the three stress environments, suggesting the presence of sufficient genetic variation and ample scope for the improvement of rice for reproductive stage sodicity tolerance.

However, we observed a highly significant difference of methylation levels between HCC and non-HCC tissues for both genes ( Table 2 ).

The most significant pathways were PI3K and cell cycle, although DNA repair, TGFβ, RAS, Wnt and MAP kinase were also highly significant, with PI3K and RAS showing the largest fold change.

A significant trend was observed for higher grain Cd accumulation to be associated with lower young leaf vs . flag leaf concentration ratios.

In accordance with previous data on PBMCs and natural surfactants [ 4 ], a mild trend of less vital and proliferated cells as well as slightly higher amount of completely unproliferated CD4 + lymphocytes could be detected after exposure to Curosurf ® in comparison to controls.

Among the SE subscales, Affective Involvement was barely significant (4% of the variance explained).

During these two studies, the strain showed an increasing trend of prevalence, 5% to 15% [ 21 , 28 ].

Both hs-cTn results remained highly significant predictors for adverse events when adjusted for significant traditional risk factors and even CCS ( Table 4 ) and CAD-severity ( S4 Table ).

Considering the significance of pairwise overlap of MCF-7 insertions with each of the five histone marks, none were statistically significant with the exception of H3K27ac, which was highly significant with a p value of 4.96E-69 (p values for all other pairwise overlaps were 1).

Fig 5C depicts a clear trend with increasing enrichment for cancer driver genes towards the most highly targeted genes in all four cell lines.

The ANOVA did not reveal any significant impact of either the phoretic phase or interacting factors (p = 0.24) ( Fig 3 ) but again, the hive of origin (p<0.001) and reproductive time (p<0.001) were highly significant ( Fig 4A ).

This was especially evident in the experimental groups, in which the peaks were highly significant.

Similarly, respondents with a monthly income of 15,000–25,900 SEK (significant) and 26,000–40,900 SEK (borderline significant) were less likely to have a ‘Fairly appropriate attitude’ compared to people within the lowest income level.

Further, individual skipping of exon 5 showed a trend of decreasing under OS, although this decrease was not statistically significant ( Fig 3B ).

The pareto chart for antioxidant capacity of raspberry seed oil subjected to UAE is shown in Fig 2(C) , and the quadratic effects of both extraction temperature and sonication time as well as the linear effect of sonication time were highly significant.

The probabilities from the planned contrasts for sex differences were both marginally significant: 0.0477 (2 hours) and 0.0497 (4 hours).

Despite the fact that major morphological differences were not observed in mutant UGS until P0, RNA-seq analysis of E18.5 mutant UGS detected a massive difference in gene expression between mutant and wild type mice with highly significant functional enrichments.

During the study period, we observed an increasing trend in the prevalence of ADR-CRM in subjects under first-line schemes, but not significant changes in the prevalence of SDRM.

A significant effect for antibiotics (OR = 0.4, 95% CI 0.2–0.8) and a marginally significant effect for nervous system disorders was observed.