Excerpts

Diagnostic evaluation Due to the highly significant difference between asymptomatic controls and SSc in many of the biomarkers, the diagnostic capacity of the biomarkers was assessed ( Table 3 ).

Nevertheless, the data analysis of the FT-IR data of quiescent cells cultivated for 14 to 100 days, showed a clear trend for separation ( Fig 4C , consistent with Fig 2C ).

In Germany, there are even indications of a negative, marginally significant, association.

Finally, we found that there was a highly significant correlation between the number CBF regulon genes in the IT, Col-0 and SW genotypes and the minimum monthly low temperature average of the region from which the genotypes are reported to have been isolated: 2.7°C for IT, -5.0°C for Col-0 and -12.6°C for SW [ 19 , 34 ] (the Col-0 accession is derived from the La-1 accession which was isolated in Landsberg an der Warthe, now known as Gorzów Wielkopolski, a city in western Poland [ 24 , 25 ].

Although official statistics point to a decreasing trend in the timber sector as a whole, possibly indicating success against illegal logging, this seemingly intractable problem continues to beset the industry [ 11 , 23 , 24 ].

Furthermore, we found a negative cumulative fluid balance on day 30 in almost all patients without AKI (95%-CI: -4.6L - -0.4L), whereas patients with an AKI stage ≥1 showed a trend to more positive cumulative fluid balance on day 30 (95%-CI: -3.1L - 1.6L), but without statistical significant difference (p = 0.078; S1 Fig ).

A clear trend of decreasing C:N ratio with increasing oil exposure was detected ( Fig 1 ), with post hoc comparisons indicating that no oil was significantly different than medium (p = 0.049) and high oil (p = 0.001).

We found a decreasing trend in SB use by drivers, by 0.5% per year during 2010–2015.

A pattern with α-linolenic and linoleic acid (TT7) showed a trend towards a higher hazard of AF in men after adjustment for lifestyle, but not in women.

In the multivariate model the variables that resulted significant at the univariate analyses and those close to significance and clinically meaningful were included.

We showed that CHRNA5 was significantly reduced by siRNA-2 and the reduction approached significance with siRNA-1 ( Fig 9D ).

For both ontology-based and compound-based classification, we find significant differences among different functional classes in the evolutionary rates dN , and dN/dS (with dS close to significance).

When we compare the evolutionary rates of these classes through a KW test we find highly significant differences with a clear gradient of selective constraints in which central routes of the core metabolism are more constrained (lower dN and dN/dS ) than the ones in the second layer which, in turn, are more constrained than those of the more peripheral layer ( Fig 2 and S3 Fig ).

They were also not significantly lower than the 90° condition, t (15) = 2.219, p = .021, but showed a trend.

If τ is greater than zero and statistically significant, there is an increasing trend; if τ is less than zero and statistically significant, there is a decreasing trend.

The largest measured influence on the extent of Trichodesmium blooms was subregion, with a highly significant regional main effect, in addition to a changing pattern in seasonal effects by region ( S2 Table ).

Analysis of the gene expression profiles demonstrated a clear trend for higher expression of genes associated with the basal subtype of MIBC.

Finally, in order to illustrate the association between a risk factor and anemia, trendline figures were generated for each continuous risk factor found to be statistically significant or borderline significant in the multivariate model.

A P value less than 0.05 is considered significant difference, while a P value less than 0.1 is considered marginal significance.

We found a highly significant association between discussing warning labels with others and being smoke-free, as reported by Thrasher et al., 2016, indicating a need to enhance this element during the design of PHWs and to identify ways to utilize it for improved outcomes [ 14 ].

Spillover effects also appear to be highly significant: Cycling has been shown to have positive effects on many factors of physical health, which outweigh the adverse effects of cycling in polluted urban areas [ 19 , 20 ].

At TCRs between 1.6 and 10°C/day, a decreasing trend in the FC was observed, whereas above 10°C/day the FC reached almost constant values, regardless of the TCR ( Fig 2C ).

Compared to Sham+Veh mice, AngII+Veh mice showed a highly significant increase in HW/BW ratio ( Fig 1A ).

A serious complication is renal cell cancer (RCC) that, in contrast to sporadic RCC, shows a strong trend towards multifocal and or bilateral manifestation.

clathratiforme showed a trend to small-celled PSB reaching up to 8 × 10 4 in July and 3.8 × 10 5 cells mL -1 in October.