Excerpts

The lack of a clear trend in these results suggests that the pattern of spiking during persistent stimulation is unlikely to be the basis of a discriminatory mechanism.

For both the host gene and the HOX gene cluster case we found a highly significant correlation between the expression of the gene(s) and the miRNAs that are linked to their co-transcription.

Despite the small sample size due to the unavailability of tissue, the 1.7-fold decrease in AβPP/AβPPα in neocortex approaches statistical significance.

There is a strong trend toward increased soluble Aβ 1–40 in lysates of FXS brain samples ( Figure 6D ) while AβPP/AβPPα levels are reciprocally decreased ( Figure 6C ) in both the neocortex and hippocampus.

While vWA-containing proteins are involved in diverse processes, it is possibly significant that expression of two of these genes is in the aboral ectoderm, which will later give rise to the calicoblast layer that will be involved in secretion of the aragonite skeleton.

In addition, 10 of 14 nuclear markers in domestic pigs were detected to have a higher proportion of pairs with significant LD than in wild boars ( Table 4 ), suggesting a slight trend toward increasing LD in nuclear DNA during domestication or breeding, which is consistent with founder effects.

Heart rate We found a strong trend towards a significantly reduced heart rate associated with visual presentations of liked brand names (mean = 73.97 bpm, SD = 8.08) compared to disliked brand names (mean = 75.16 bpm, SD = 9.17).

The specifics of the analysis will typically have more relevance when statistical results are nearly significant at the alpha = .05 level.

A point that must be noted here is that the extent of geo-spatial clustering has followed an increasing trend over the three survey rounds.

The marginally significant results did not change our overall perception of the patterns, but it helped us to take in account additional, potentially important factors that would have been ignored by only looking at the significance level of p≤0.05.

Based on the c-scores performance of the individual data types, the DNA methylation signature is the most statistically significant, the microRNA signature is borderline significant among PFS signatures, and microRNA is borderline significant among OS signatures ( Table 2 ).

Although borderline significant, it is noteworthy that both fatty acid metabolism and lipid biosynthetic process functional groups figured among the top categories of over-expressed genes in naked mole-rats.

drakensbergensis Fu's Fs indicated a marginally significant demographic contraction (Fs = 5.15, Prob sim_Fs>obs_Fs = 0.052).

Within the limitations of this particular animal model, the fact that EGFP positive cells were extremely rare at birth may be significant.

From 25 mM onwards, a clear trend indicates that toxicity is higher for the gemini surfactants than for the corresponding single-tailed surfactant.

Because values of synchrony are not completely independent, 95% confidence intervals for each path were estimated by bootstrapping ( n = 10,000) [4] where a proportional overlap of less of 0.5 could be considered significant [39] .

Although a positive trend was observed in ejection fraction and fractional shortening for BIM 28131.

However, the results could be applied to other disciplines and may be significant in the wider preclinical and clinical worlds.

The effect was highly significant in the three animals and was not restricted to epochs during which the two signals have exactly the same frequency.

The favorable genotypes for rs12979860 (CC) and rs8099917 (TT) were associated with spontaneous clearance, although borderline significant.

Nevertheless, a stable national trend and a decreasing trend in the Northwest for NRTI TDR are consistent with observations in other countries that report reductions in TDR prevalence, which may be associated with the broad use of high-potency, first-line ART regimes [1] , [12] , [14] .

The apparent thermodynamic stabilization by these forms is quite significant when compared to other conformational stabilizers (e.g. sucrose) [20] given that the results likely represent a combination of conformational stabilization and association suppression.

Although some may consider the estimated prevalences of SGI1 to be qualitatively similar, the fact that highly significant differences have been demonstrated between the populations is a strong indication that the two populations are not as well-mixed as has been suggested previously [10] , [13] .

At the 20-minute time point, we observed a decreasing trend in respiratory rate between Day 2 and Day 8 ( Figure 1A ).

Moreover, an increasing trend in functional connectivity amongst the anterior cingulate cortex and atlas-defined VOIs such as the retrosplenial cortex, parietal cortex and hippocampus can be observed across Days 2-8 ( Figure 2C ).