Excerpts

Baseline EDSS was also a highly significant predictor of outcome using standard logistic-regression analysis [14] In both analyses, the EDSS out-performed the MSSS.

We observed highly significant differences in the ability of complement proteins in blood plasma from M. lucifugus to lyse E. coli , S. aureus , and C. albicans across all samples.

Finally, FACS analysis of cells stained for Brachyury, SMA or MyoD revealed an interesting trend.

A clear trend to increase of these signs following nicotine cessation was always observed.

Although only few of these residues had been reported [27] , [28] , their undetermined effects on virus pathogenicity may be significant.

Whereas miRNAs did not seem to target the 3′ end of the 3′UTR (2574–3180), the remaining fragments mediated a slight increase in reporter activity upon Dicer knock-down and the 5′ fragment 1–449 nt showed a highly significant effect.

An investigation of human post-mortem brain tissue recently showed a trend for reduced DRD4 mRNA expression in samples carrying at least one seven-repeat allele [37] .

As a consequence, even highly significant changes in a specific tissue or organ are often under-represented or masked in such bulk analyses, highlighting the need for refinement of existing methods.

The mitochondria of irradiated hearts showed a trend to a smaller size but this did not reach significance.

Group II brains showed a trend towards astrocytosis, with some tufted cells.

As for the function of NMDAR-mediated intracellular signaling, physical interaction between CaMKII and NMDAR may be significant for signaling triggered by NMDAR-mediated Ca 2+ influx [34] .

The similarity of faunal patterns found at each of the two sites is telling while the difference between the sites remains highly significant across all archaeological layers.

In the female-offspring nuclear families, rs2075252 and haplotype GA of rs4667591 and rs2075252 were identified in the nominally significant total association with peak BMD at L1-4; however, no significant within-family association was found between peak BMD at the L1-4 and hip sites and six tagSNPs or haplotypes.

Paired t-test indicated this reduction in alignment uncertainty was highly significant with a P value of 1.99e-32.

This might be significant for hibernators as WAT depots are gradually depleted to provide fatty acids for oxidation.

Although our data suggest that there may be significant functional compensation when brain ganglioside distribution is altered by VCS, Figures 6 and 7 demonstrate that these changes are not without effect.

IL-2 showed a highly significant increase in MFI in the IFN-γ + TNF-α + and triple producers (ρ<0.001).

Thus, the expression of IFN-γ, IL-2 and TNF-α was significantly greater in the multifunctional (double & triple) populations that in any of the mono-functional populations and there was an overall trend of higher quality of response as the cells increased in function.

Table 4 lists several highly significant pooled effects, although moderate to important levels of statistical heterogeneity were typically present.

This result can also be regarded not only as statistically but also as practically significant, as there is a 0.08 difference in EQ-5D index scores between the lowest degree of the Morisky score indicating poor medication adherence, and the highest score indicating best medication adherence.

However, we found a weak trend of the core area of home range size to increase with decreasing biomass of preferred plants, suggesting that females adjust the size of the core area of their home range to the amount of resources they can obtain.

While the plant showed a trend towards a geographically-driven structure of its genetic variation ( Figs. 1C and 1D ), insect haplotypes were distributed without regard to any spatial signal ( Figs. 2 and 3 ).

For both colony-based ( Table 4 ) and area based electivity ( Table 5 ), interactions between the covariates and the categorical predictors were highly significant.

The prognostic values of both signatures were highly significant in the finding cohort when analysed as a continous variable in multivariate Cox regression ( Table S4 ).

With exclusion measures installed there was a highly significant reduction in the frequency of visits to all types of facility, though the reduction in entry to feed stores was greater than in cattle housing ( Table 2 ).