Barely Significant

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Comparison of the phenotype of the Adamts5 -/- -J mice of the present study with that of the Adamts5 -/- -P mice reveals some similarities supporting specificity of the phenotype, but also some quantitative and qualitative differences: (i) with respect to WAT mass: in Adamts5 -/- -J mice lower sWAT and GON fat mass was found, which was significant after 2 weeks of cold exposure, but only showed a trend in the DIO model; (ii) with respect to BAT mass: in Adamts5 -/- -J mice no significant difference with WT mice was observed after 2 weeks of cold exposure nor in the DIO model; (iii) with respect to browning of WAT: in Adamts5 -/- -J mice higher expression of UCP-1 mRNA and protein was found after 2 weeks of cold exposure (mRNA: 1.5- to 2-fold as compared to 5-fold for Adamts5 -/- -P mice).
highly significantqualifiedgold
Differences in log 2 fold change values for the T6SS island proteins are highly significant for proteins detected in 5 or more replicate experiments, but have lower or no statistical significance for proteins detected in 2 or fewer replicate experiments despite the fact that the genes encoding these proteins are present only in isolate 00–1597 ( S4 Table ).