Excerpts

A p -value < 0.05* was deemed statistically significant, a p-value < 0.01** was considered highly significant, a p-value < 0.001*** was denoted as extremely significant, and a p-value < 0.001**** was denoted as exceptionally significant while 'ns' indicated non-significance.

Cells were harvested 24 hours post transfection to assess GFI1 expression levels by quantitative RT-PCR, revealing a highly significant down regulation of both GFI1 RNA (p < 0.001) (Fig. 4A ).

The other participants all showed a highly significant VWFA cluster on a single-subject level (FWE-corrected p < 0.001) and positive beta values when extracting the mean beta value for the “words versus checkerboards” contrast from a VWFA mask based on literature (see Methods section and Supplemental Material Sect. 1 for a description of the literature-based mask).

Indeed, for NH 4 + -N and total organic N, all individual treatments, all two-way interactions and the three-way interaction were highly significant ( P < 0.001; Supplementary Table 2 ).

Exceptional potassium dynamics Potassium concentrations represent a remarkable exception to the geological dominance pattern demonstrating highly significant seasonal variation (F = 28.69, p < 0.001) with a large effect size (η 2 = 0.196).

Association between gut microbial taxa composition and intestinal FDG uptake In the analysis of gut microbial abundance of patients in each of the visually graded IU groups, the genus Enterobacter , which belongs to the family Enterobacteriaceae, showed a trend of higher relative abundance in high IU group compared with low IU group ( CE = 1.08; p < 0.001; q = 0.094; Supplement Fig.

The statistical differences in the year and country of reporting for AEs associated with IV versus INH administration were both highly significant ( P < 0.001).

p < 0.01 highly significant (**). p < 0.001 very highly significant (***).

However, analysis of elevational trends by years revealed two significant opposing linear trends for total, mycorrhizal and saprotrophic biomass; a decreasing trend in 2012 (slope total = −2.19 ± 0.95, P = 0.023; slope sapro = −0.89 ± 0.35, P = 0.013) and an increasing trend in 2013 (slope total = 3.48 ± 0.95, P < 0.001; slope sapro = 0.90 ± 0.35, P = 0.011).

Differences were considered significant for p value < 0.05 (*), very significant for p value < 0.01 (**) and extremely significant for p value < 0.001 (***) and p value < 0.0001 (****).

Furthermore, compound 24 caused highly significant ( p -value < 0.001) down-regulation of the gene expressions of ORF1a / b , ACE-2 , and RdRp with fold-changes of 2.05, 0.58, and 1.4, respectively (Fig. 4 A–E) as compared to the drug control RDV.

Compared with the normal group, crg-miR-130-3p (7.372 ± 0.3416 vs 1.085 ± 0.06151), crg-miR-142-5p (5.228 ± 0.07653 vs 1.117 ± 0.01856), crg-miR-21-3p (14.250 ± 0.5306 vs 1.214 ± 0.08204), and crg-miR-34c-3p (5.598 ± 0.2093 vs 1.043 ± 0.04295) increased extremely significant ( p < 0.001) and had relatively high and stable expression levels in the cancer group.

When cotton was used as a substrate, ML and L showed a highly significant increase in attractiveness towards female house flies ( Fig. 4a , ANOVA , F 4, 45 = 6.97, P < 0.001).

A highly significant increase (p < 0.001) of angiotensin I (Ang I) was observed in ACE2 KO mice, which was accompanied by elevated concentrations of its downstream metabolites including Ang II (p = 0.027) and Ang-(1-7) (p = 0.023) ( Fig. 1a ).

As expected, temperature had highly significant effect on the amount of fat stored ( P < 0.001) (Supplementary Table S2 ).

This analysis revealed a highly significant negative correlation between the expression of TFR1 and miR-148a ( r = −0.435, P = 0.001) (Fig.

Lambda was found to be high and highly significant (λ > 0.6; p < 0.001) for all traits.

In the monetary domain, the correlation between risk and ambiguity attitudes remained highly significant but slightly decreased in both phases (Phase 1: r = − 0.445, p < 0.001; Phase 2: r = − 0.394, p < 0.001).

Bone loss was highly significant at 30% 2D RL but not at 30% 3D RSA ( p < 0.001, Table 2 ).

There was a highly significant main effect of F0 [ F (1,13) = 89.95, p < 0.001, partial eta-squared ( η p 2 ) = 0.87] as expected.

ET) revealed a highly significant difference for the factor stimulation condition (ventral contact: F = 113.31, p < 0.001; dorsal contact: F = 62.58, p < 0.001), but no significant interaction between stimulation condition and disease.

Heterogeneity was highly significant ( p < 0.001) in yield, biomass, height, stem diameter, WUE, stem diameter, weed biomass, moisture content, temperature, pH, AP, and K.

Highly significant (p < 0.001) differences in synchrony were detected between stimuli with the greatest and the lowest Gestalt-likeness for the proximity and similarity principle, and significant difference (p < 0.01) for the continuity principle.

However, two interaction terms, puffing temperature-sample moisture and puffing temperature-moisture content were highly significant ( p ≤ 0.001), indicating the critical role of thermal and moisture dynamics in phenolic retention.

It is observed that L-SLNs (5 mg/kg, 10 mg/kg) showed a moderately significant ( p < 0.001) improvement, as these groups spent less time both in the open arm and the closed arm, as compared to the disease group, indicating improvement in cognitive behaviour, as shown in supplementary Table 4.