Barely Significant

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To ensure participant safety and that healthy volunteers were not exposed to additional risk of harm (either due to high rates of side effects or continuing unnecessary prolongation of the study once a highly significant difference had been observed) safety monitoring was undertaken by members of the research team at each study visit.
Further analysis revealed that EMT was an extremely significant mechanism regulated by CTHRC1 + GREM1 + myCAF (Fig. 3 e, f, Supplementary Fig. 2F ), indicating these fibroblasts support cancerous cell differentiation and proliferation leading to rapid tumor growth and potential metastasis.
4 ), except for an increasing trend in OS of platinum-sensitive patients compared to platinum-resistant/refractory patients (median OS: 25.5 months vs. 13.8 months, univariate (UV) HR: 1.96, 95% CI: 1.00 to 3.85, p = 0.05) though this trend was not observed in the MV analysis (MV HR: 2.04, 95% CI: 0.83 to 4.98, p = 0.12).