Excerpts

They appear to be overall most abundant in the lower part of core 479 G below approximately 310 cm core depth, but with quite significant fluctuations throughout the length of the core (Fig. 2 , S2 ).

In fact, the DNA methylation patterns of iPSC-derived cells cultured under different conditions revealed highly significant and reproducible differences.

Therefore, we next analyzed the correlation between NIP45 and NFATc1 mRNA expression in the blood cells of these children and found a highly significant direct correlation between the expression levels of these two transcription factors both in healthy controls and in asthmatic children (Fig. 2a,b , respectively).

In lung, however, we observed a >10-fold increase (with highly significant FDR corrected p-value), in the endogenous levels of hydroxyphenyl-2-hydroxyethyl oleamide (omdm-2) at both doses of amifostine tested in the study.

Upon prestimulation of the cremaster muscle with LPS, however, cessation of blood flow was significantly accelerated and a slight trend towards an even faster onset of platelet adhesion was noted, although not reaching statistical significance (Fig. 1B–D ).

Supplementary File 2 : Table S2 lists the highly significant positive-oriented and negative-oriented gapped dipeptides observed in these sequons along with UniProt evidences and the N-GlyDE prediction scores.

Hence the GH+ group showed a trend towards higher rates of cardiac and urogenital abnormalities as well as higher proportion of patients who declared lymphedema and feeding problems during infancy.

Results Long-term trends and periodicities Total phytoplankton biomass (TB hereafter) experienced a decreasing trend in Las Madres lake for the whole period under study (Fig. 1a ).

The analysis of time series using AEM revealed a negative trend for TB from 1992–2016 (Table 2 ), as already mentioned, and two further periodicities: a decadal (17 years) and an annual one (Table 2 ).

Throughout the whole series (1992–2016), all biomasses of taxonomical groups (TGBs hereafter), except that of Diatoms, showed a trend and periodicity in their dynamics (Table 2 ).

7 ), plant hormone signal transduction was downregulated in pairwise JCFI vs JCFII and JCFII vs JCFIII but showed a trend to upregulate in pairwise JCFIII vs JCFIV; starch and sucrose metabolism was upregulated in pairwise JCFIII vs JCFIV; protein processing in endoplasmic reticulum was upregulated in pairwise JCFIII vs JCFII; tryptophan metabolism associated with auxin metabolism was upregulated in pairwise JCFI vs JCFII; alpha-linolenic acid metabolism associated with JA metabolism was upregulated in pairwise JCFIII vs JCFIV; phenylalanine metabolism associated with SA metabolism was downregulated in pairwise JCFI vs JCFII.

The S6k1 −/− mice showed a trend for being hyperactive, but this did not reach significance for either gender (males: F 1,33 = 1.266, P = 0.271; females: F 1,31 = 3.265, P = 0.080).

In our study, current smoking was not associated with 15D, but ex-smoking remained of borderline significance.

Partially controlled asthma, BMI, previous smoking and number of drugs in use (other indications than asthma/allergy) were not associated with poorer 15D score, even though the two latter had borderline significance (Table 3 ).

A decreasing trend of H 2 O 2 concentration was observed in the release media from 48 to 72 hours, that may be attributed to an ageing of H 2 O 2 , as observed in cell culture media 37 .

This knowledge is extremely significant in order to minimize the environmental aftereffects of open-pit mining in Europe.

The COD concentration showed a trend with two distinct peaks where the highest concentration was observed either early morning between 8:00 am to 9:00 am or early night around 8:00 pm.

While our study showed an increasing trend in nutrient concentration during the SW monsoon, the chlorophyll did not show any trend.

DFA also allowed us to unveil that the migration movements of cells and cytoplasts exhibited a trend-reinforcing behavior i.e., if the locomotion trajectories present a decreasing trend in the past, it usually implies a decreasing tendency in the future and vice versa, an increase in a set of the move-step values in the past is likely to be followed by an increasing trend in the future (Methods Section).

While the 88% classification accuracy, supportive results from the 10-fold cross-validation, and highly significant predictor variables included in our model indicate a robust cross-sectional model for identifying general patterns of current estuarine hard armoring at the parcel scale, we acknowledge that our analysis cannot encompass all potential drivers of hard armoring emplacement.

3b , shows a negative trend between the strength of activities and measured PEPs.

Finding a clear trend between PAT and postures seems to be complicated.

The p-value for Λ is borderline significant for the rectangular ROIs, with the optic disc region of DR group being different from all other groups, while for the circular ROI p-value is not significant (Supplementary Table 2 ).

4(b) show an increasing trend of ~6 μg/m 3 (4%) per year (total 60%) over the period 2002–2016.

A 15-year long record (2002–2016) of NASA’s A-train satellite measurements have revealed a positive trend in the total fire activity and resulting aerosol loads over IGP.