Excerpts

Initial data analysis of SUDHL2 dataset failed to detect GLUT1 and HK2 because of the highly significant pre-established criteria set for RNA enrichment co-correlation analysis.

Functional analysis of the differentially expressed mRNAs In evaluating the top differentially expressed mRNAs (n = 250), we found a highly significant enrichment for several functional annotations (Supplemental Fig. 5 ), including acetylation (genes post-translationally modified by the attachment of at least one acetyl group; n = 85 genes; Fold enrichment = 2.2; Bonferroni-adjusted p = 4.2 × 10 −11 ), mitochondrion (the site of tissue respiration

In the multivariable-adjusted model, those in quartile 3 had lower odds of severe DR or worse versus the combined no DR and minimal-moderate DR categories, than those in quartile 1 (OR, 0.35; 95% CI: 0.17 to 0.74; P = 0.006; per categorical increase in severity Model 2 in Table 2 ), and a significant trend for increasing frequency of fish consumption (P-trend = 0.024).

The maximum loading rates under different preset pressure are listed in Table 1 , where an increasing trend can be observed.

The SAH volume showed a trend to be a negative determinant (OR, 0.91; CI, 0.81 to 1.01) for favorable outcome.

P < 0.05 was considered statistically significant and P < 0.10 was considered to be trending toward significance.

There was no significant change in the intensity or area of the B-form helix conformation of DNA, while there were quite significant changes for the Z conformation of DNA.

Due to the fact that the P value was close to significance threshold, we performed additional separate paired Student’s t -tests (uncorrected), to test whether differences between both conditions (EF vs IF) occurred for any phase.

Both of the top peach and shrimp allergy associated SNPs were nominally significant in apple and crab reactive subjects (Top peach SNP: rs28359884, P apple = 5.75 × 10 −6 ; Top shrimp SNP: rs74995702, P crab = 1.22 × 10 −3 ).

We also observed an interesting trend that microhomology was less commonly associated with deletions of ≥50 bp (Table 2 ).

Figure 3 shows that on an annual basis, less than 36% of the ice-free Greenland has experienced a significant trend and, if any, a cooling is observed during the last 15 years (<0.15 °C change per year).

In the 1990s, highly positive J / w values (more than +25 μmol kg −1 km −1 ) with an increasing trend were found for CW, and negative J / w values (less than −10 μmol kg −1 km −1 ) with a decreasing trend were found for DW, indicating increased (decreased) convective supply of DO to CW (DW).

The correlation coefficient between the Ct values of each allele was highly significant (Supplementary Figure 6 ).

From Arg0 to Arg3, there was an increasing trend of lipophilicity and molecular weight.

The incidence of OTSCC has shown an increasing trend in the population based cancer registry (PBCR) in India 9 , 10 .

Although the mRNA expression of eNOS was unchanged, the protein expression of eNOS showed an increasing trend with increasing stretch magnitude (Fig. 3b , Table 1 ).

vgll3 showed a trend of being up-regulated, however this was not significant (P = 0.0519, Supplementary Fig.

Generally, cbhI gene abundance in early-rice season was generally higher than that in late-rice season, and the difference was extremely significant at d14 and d28.

The evaluation of the IgG titers against NadA showed an increasing trend with each vaccination dose in the groups that received NadA as part of the vaccine formulation (Fig. 5b ).

Moreover, the bacterial community diversity showed an increasing trend from endophytic to rhizoplane and rhizosphere soil.

These studies are highly significant and clinically relevant to understand the emergence of drug resistance; addition of Dasatinib to Docetaxel, a cytotoxic chemotherapy drug targeting microtubules, did not improve the overall survival in Phase 3 trials for chemotherapy-naive men with metastatic CRPC 33 .

An increasing trend in TDF values from 2.5 to 3.4‰ as crocodilians age was simulated in our analyses to examine the sensitivity of the trophic position estimate using varying TDF values 39 .

With regard to TB prevalence, an increasing trend was observed over time (Fig. 1 ).

An increasing trend is observed with the plasma discharge power increased.

Several PBDEs were positively associated with fT3 in this population, including BDE-28/33, BDE-47, BDE-100, and a marginally significant association for BDE-99.