Excerpts

3C ), with the Kolmogorov-Smirnov test revealing a highly significant difference in the two distributions (p = 2.2×10 −16 ).

The Spearman’s correlation coefficients (ρ) between the positions of the markers on linkage map and physical map were positive (0.996-to-0.999) and highly significant (p-value < 2.2e -16 ), with an average of 0.999 ( Supplementary Table 5 ).

Somewhat surprisingly, we found a reasonably strong and highly significant correlation between these values ( R =–0.28, p<2.2e-16).

We find a highly significant departure from the expectation that the mean blunting score is equal to zero (two-tailed one-sample t test P < 2.2 × 10 −16 ), demonstrating that deletion of ENH5 results in a transcriptome-wide dampening of the response to sustained hypoxia ( Fig. 3E ).

We observed a highly significant gain of methylation with age at the locus in the LBC cohort, validating our approach (Fig. 1 a, T-test, p < 2.2 × 10 −16 ).

A total of 190,678 gene pairs had at least one TSG, and the difference in p -values between pairs with TSGs and with no TSGs was highly significant ( Figure 3 , Wilcox rank-sum test p -value < 2.2 × 10 –16 ).

By linear regression analysis, the correlation between the two are highly significant (Spearman's rank correlation = 0.83, P-value <2.2×10 −16 ).

A clear trend is observed between symmetry [ 35 ] of eruption in the upper and lower arches ( p -value < 2.2 × 10 −16 ); therefore, the probability of a child having symmetry in the lower arch while he also has upper symmetry (and vice versa) is high.

The overlap was highly significant (Fisher’s exact test P value <2.2 × 10 −16 ).

To test this prediction, we performed DRIP-seq in ovaries dissected from adult females and found strong, highly significant correlations between the female whole fly samples and ovary samples for both nonDE and FE peaksets from the adult data (Spearman’s rho > = 0.72 and P < 2.2e-16 in all comparisons, S2D Fig ).

However, it is interesting to note the highly significant co-directionality (binomial test: p < 2.2e−16) of the expression changes observed for nitrogen-limited cultures and in hospite symbionts, with 92.67% of the 12,295 (11,394) DEGs changing expression in the same direction (Fig. 2 e).

2 A), which was still highly significant ( p = 2.2e-16) due to the number of data points.

The results indicated highly significant Pearson correlation coefficients of −0.82, −0.68, −0.78, and − 0.71, respectively, with P -values < 2.2e-16 ( Fig. 3B-E ).

These differences in seed set between the ‘selfed’ and ‘tagged’ treatments between AZ-SC and the SI sites are highly significant ( F = 128, P < 2.2e-16 for selfed; F = 110.4, P = 2.2e-16 for tagged).

There is a highly significant overlap in the promoters that gain hmC at 12 hrs and those that lose mC at 72 hrs ( P value < 2.2×10 −16 , Fig. 1d , Supplementary Fig. 6 ).

As expected, we observed a highly significant difference between RefSeq mRNAs (NM) and RefSeq non-coding RNAs (NR) for both the CPC and the RNA-code score (CPC t = 56.4326 [2.239631;2.400904], p-value<2.2×10 −16 , RNAcode t = 39.6171 [34.44711;38.03595], p-value<2.2×10 16 ).

While the p -values are highly significant ( p -value < 2.2e–16), this is likely due to the large sample size, and the relationship between TE content and gene expression is rather weak (Fig. 3 G), suggesting that genes can be highly expressed despite containing substantial intronic TE densities.

For both the OE and VNO, the correlation values were highly significant ( P < 2.20 × 10 −16 ), and the correlation coefficients between samples from the same subspecies were higher than those found between samples from different subspecies ( Supplementary Table S5 ).

Statistical analysis using an independent two-sample t -test (Welch’s correction) revealed a highly significant difference in mean PC1 values between the two groups ( P < 2.2 × 10 −16 ).

Interestingly, pairwise comparisons of the data from each analysis yielded highly significant positive correlations (Pearson’s test, P < 2.2 × 10 −16 ) ( Figure 3 ; Supplementary Table 3 , available online).

Given this trend, we fitted a logarithmic model to the data, which was highly significant [linear regression F ST ~ log( D a ), P < 2.2 × 10 −16 ; Pearson correlation coefficient, R 2 = 0.96].

Our results demonstrate that subtype indicators are highly significant in predicting survival ( p -value < 2.2 × 10 −16 ).

The Welch 2 Sample t-test indicated a statistically highly significant difference in PRS between the 2 dietary categories ( t = −32.758; P = 2.2 × 10 −16 ).

This difference of 44,043 bp is highly significant (χ2 = 30823.1, df = 3, p-value < 2.2e-16) and corresponds to a 61 % increase of the S. latifolia chromosome size as compared to S. vulgaris .

The difference in the location of the median for the success statistic distributions obtained using the two approaches was highly significant ( p < 2.2e‐16) for all three drugs and showed that the PopPK approach performed significantly better than a standard NCA approach.