We also confirmed highly significant correlations of the patterns of transcriptomic changes (FC of each gene) between cells with homozygous and heterozygous variants ( Figure S18 , p < 2.2 × 10 −16 for both chr7:g.26200781C>T and chr22:g.19179942C>T lines).
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Among these were 20.0% of the genes upregulated in XY° males (993 out of 4973) versus 40.8% of the genes upregulated in XX females (3856 out of 9472) in at least one developmental stage (FDR < 0.05), a highly significant difference ( χ 2 = 330.0, p < 2.2e−16).
3C ), with the Kolmogorov-Smirnov test revealing a highly significant difference in the two distributions (p = 2.2×10 −16 ).
The effect of the fly strain on CCRT was highly significant (Kruskal–Wallis test, p < 2.2 × 10 −16 ).
S6 , we found a highly significant correlation between amplicon genus abundance PCoA1 and shotgun species abundance PCoA1 (the Spearman’s correlation ρ = 0.881 , p-value < 2.2 × 10 - 16 ).
Out of 387 proteins associated with gestational age in human amniotic fluid, 225 (58%) were also associated with gestational age in rhesus and the correlation of effect sizes between the two species in the 225 overlapping false discovery rate (FDR) significant proteins was highly significant (R = 0.75; p < 2.2e–16; Fig. 4 ).
We found a highly significant enrichment (Fig. 5 ; P < 2.2e-16) of small GWA P values for LD blocks with a sQTL in the German DCM GWAS (909 cases versus 2120 controls), which was subsequently replicated ( P < 2.2e-16) in the international DCM GWAS (1179 cases versus 1108 controls).
Overall, the results exhibited a clear trend of the MAS level increasing with increasing simulated resistance (Spearman’s rank correlation ρ = 0.71, and p = 2.2E-16).
Strikingly, PFC Aliceblue and NAc Cadetblue 2 showed a highly significant overlap in their gene content, with 72 overlapping genes ( S2 Table ; p = 2.2 x 10 −16 ).
There was a highly significant correlation ( r = 0.876, P -value <2.2 × 10 −16 ) ( Supplemental Fig.
This revealed a highly significant association between gene age and expression specificity in both species ( D. melanogaster : χ 2 = 1092.66, df = 5, p < 2.2 × 10 −16 ; A. aegypti : χ 2 = 890.74, df = 5, p < 2.2 × 10 −16 ), indicating that stage‐specific genes are significantly enriched for evolutionarily young genes. 2.4.
We observed a highly significant deviation from the expected distribution (Chi-squared test, p < 2.2 × 10 –16 ), indicating strong cell-type-specific expression patterns.
The coefficients derived from the linear regression of each sample pair were highly significant ( P -value <2.2e-16), and the quality of the fit was assessed using R 2 and regression coefficient values ( Fig. 6B and C ).
This is exemplified by the colocalization of DPDs with regions of higher CpG density ( Figure 6B ) and a robust and highly significant negative correlation between CpG density and PMDs (r = −0.64, P<2.2×10 −16 ).
All regressions were highly significant ( p < 2.2 × 10−16).
Finally, we observed a highly significant increase (one-sided Student’s t -test, p = 2.2 × 10 −16 ) in average epistasis values in the winning CR genotypes compared with the overall population, indicating that positive epistasis plays an important role in determining the fittest genotypes in this selection (Fig. 5b ).
This difference was highly significant ( χ 2 = 482.2; P < 2.2e -16 ), indicating that ancient gene pairs have been highly dispersed.
Of the 236 transposable elements detected in our RNA-seq data, 97 are differentially expressed in xct-2 , representing a highly significant enrichment (1-tailed Fisher's exact test, P < 2.2e–16; Fig.
The analysis revealed a highly significant enrichment ( p < 2.2 × 10 −16 ) of QTLs within CNVRs.
A Cochran–Armitage test for trend confirmed a highly significant positive association between engagement level and success rate (χ 2 = 85.34, df = 1, p < 2.2 × 10 −16 ) ( Figure 3 ). 3.4.
We found that the correlation values were highly significant between them all ( Figure 1 , Pearson correlation coefficients of at least 0.95, p -value < 2.2 × 10 −16 ).
Averaging power in this range across the entire cue presentation period revealed a highly significant difference between the six regions in the 3-s spatial working memory task (F 5,1096 = 19.98, p = 2.2E-16, effect size: η 2 = 0.09).
The Kruskal–Wallis test revealed highly significant differences between conditions at 0–24 h (H = 147.38, df = 2, p = 2.2 × 10 −16 ) and 24–48 h (H = 121.46, df = 2, p = 2.2 × 10 −16 ).
This correlation was highly significant ( p < 2.2 × 10 −16 ), indicating that the observed similarity is unlikely to occur by chance. 2.4 Expression of PAMPs and DAMPs in Human and Murine pDCs Quantitative proteomic comparison of human and murine plasmacytoid dendritic cells (pDCs) revealed selective, pathway‐specific differences rather than global proteome shifts.
239.3 cm) compared to Sb, and in both cases differences resulted highly significant ( p = 2.2×10 −16 and p = 2.7×10 −15 for MAT and PH, respectively).