The final model was highly significant ( p = 2.2e−16), and for all three cancer types IRF1 was identified as a significant explanatory variable for CD274 expression (Table 1 , left 3 columns).
Excerpts
When the test was conducted with results adjusted for cohort, PCs, age, and gender, the over-representation of risk associations remained highly significant ( p value < 2.20 × 10 −16 ).
A comparison of frequencies with Pearson's chi-squared analysis showed a highly significant increase of negative probes in the immune group ( p < 2.2e − 16).
Notably, 67% of annotated cancer genes are associated with S100A8/A9 target genes, in comparison to only 55% of noncancer genes, which is highly significant ( P < 2.2 × 10 −16 ; Fisher’s exact test) with contributions from ONG ( P = 2 × 10 −8 ), TSG ( P = 2 × 10 −14 ), and OncoTSG enrichment ( P = 6 × 10 −6 ).
239.3 cm) compared to Sb, and in both cases differences resulted highly significant ( p = 2.2×10 −16 and p = 2.7×10 −15 for MAT and PH, respectively).
Analysis of application inflow Davies‘ test for significance of breakpoints resulted in a highly significant change in the slope of the participant inflow ( p -value < 2.2e − 16 ).
We calculated an odds ratio for this value using a Fisher's exact test and found this association to be highly significant (odds ratio=3.02; P <2.2×10 −16 ).
The polarity score analysis of all expressed ORFs revealed a small but highly significant shift of ribosomes toward the 5′ end of ORFs when RPLP1/2 were depleted (mean of the differences = 0.013, P = 2.2 × 10 −16 ) ( Supplementary Figure S12A ).
Before harmonization, a Type III ANOVA revealed a highly significant site effect on global mean connectivity (F(12, 623) = 9.65, p < 2.2 × 10 −16 ).
The Kruskal–Wallis test revealed highly significant differences between conditions at 0–24 h (H = 147.38, df = 2, p = 2.2 × 10 −16 ) and 24–48 h (H = 121.46, df = 2, p = 2.2 × 10 −16 ).
The difference in the comparison of In100-element flanking exons and the control exon pairs is highly significant (Fisher's Exact Test, P<2.2×10 −16 , df = 1; Figure 4 ).
CXCL17 was the only chemokine or chemokine receptor in the top 250 most significantly differentially expressed genes and showed a highly significant positive correlation with B7-H4 mRNA expression (Spearman Rho = 0.53; p = 2.2 x 10 −16 ) (Supplementary Figure S8).
Results Phenotypic variance decomposition and heritability of partial resistance to bacterial canker Considering differences between all controls and inoculated shoots regardless of the genotype effect, a highly significant effect of bacterial inoculation was observed (Wilcoxon unilateral t.test p < 2.2E-16) for lgc whatever the year and for bs in 2013 and 2015 (lesser extent in 2014 p < 9.77E-12 and 2016 p < 9.06E-06).
The overall model was highly significant ( F (5, 182) = 26.86, p = 2.20 × 10 −16 ), with an adjusted R 2 of 0.409, explaining 40.9% of the variation in the hematocrit retention ratio.
In fact, among the 291 genes selected for pad4 , 170 genes are also included in those for sid2 : the overlap was highly significant ( p < 2.2 x 10 -16 , Fisher’s exact test).
The overlap was highly significant (Fisher’s exact test P value <2.2 × 10 −16 ).
Correlation analysis shows that genes expressed at higher levels are better correlated across both platforms than those expressed at lower abundance, although both are highly significant ( p < 2.2E-16).
Fisher’s exact test revealed a highly significant association between treatments and inhibition scores at both 24 hpi and 96 hpi ( p < 2.2 × 10 −16 ).
DNA methylation at 84.7% of these sites was significantly associated with at least one common genetic variant using a stringent mQTL threshold (P < 1x10 -8 ) ( S2 Table ); this represented a highly significant enrichment for mQTL effects (P < 2.2x10 -16 ) compared to less-heritable DNA methylation sites (defined as those with A < 0.8), amongst which only 24.5% were associated with a mQTL variant.
Comparison of variance in global methylation between the depressed twin and their unaffected co-twin revealed a highly significant increased genome-wide variance in twins with MDD in both the UK and Australian cohorts ( P < 2.2 × 10 -16 in both datasets).
The difference between the electrolytic approach (test groups 1, 3, and 5) and PSS (control groups 2, 4, and 6) was statistically extremely significant ( p -value < 2.2 × 10 −16 ).
Samples tended to cluster according to batch of origin, indicating systematic rather than random variation with highly significant differences in LCR-associated z-scores across batches (Kruskal–Wallis p < 2.2 × 10 −16 ) and multiple significant pairwise contrasts identified by Wilcoxon tests.
In addition, 82.5% of DMR-associated transposons are annotated as containing a transposable element gene, a highly significant enrichment compared with all annotated transposons (Fisher’s exact test, P <2.2e−16).
We observe a highly significant 3-way MT × N × E interaction ( P << 2.2 × 10 −16 ) ( Table 1 ) and highly significant MT × N epistasis within each of the 6 conditions ( Table 2 ).
The concordance score based on the χ 2 -test is highly significant (p < 2.2e-16), and the overall accuracy to clinical types is 71.6%, as measured by rand measure, a metric for the percentage of agreement on a pair of samples belonging to the same group.