This is highly significant according to an exact binomial test ( p < 0.001).
Excerpts
Previously reported data demonstrated a pronounced TP53-dependent differential response of HL cell lines to etoposide treatment: TP53-wildtype L-540 cells responded faster and more robustly than TP53-mutant L-428 cells with respect to reduced proliferation and viability, induction of apoptosis and necrosis (absent in L-428), accelerated nuclear fragmentation, and highly significant differential expression of apoptosis-related genes ( p < 0.001), including TP53, TNFα, HO1, and GADD45.
The difference in SGUS scores between SS patients and controls was highly significant ( P < 0.001). 3.2.
All reported reductions were highly significant (p<0.001) due to the forced modeling.
Covariates with an indication for sex trends Of all the sociodemographic factors assessed for sex differences, we found the age of the patient, educational attainment, occupational status, and outcome at discharge showing a significant trend (p<0.001).
For the color, identity, and location questions, the only independent variable that had predictive power was semantic relatedness (Figure 5 A), which was highly significant in all cases ( p < 0.001).
The results showed improvement in plaque index, which showed a mean difference of 1.78±0.51 with P <0.001 between baseline and 1 month, which was highly significant; and at 3 months, the mean difference was 1.75±0.50 with P <0.001 [ Table 2 ], which was highly significant.
Nevertheless, the performance differences observed for the different taper types are generally highly significant ( p < 0.001) and unlikely to have occurred by chance.
A repeated measures ANOVA including the within-subject factors RESPONSE (errors versus correct hits) and CONDITION (placebo versus control), carried out on the ERN amplitudes averaged across the three frontocentral electrodes (Fz, FCz, and Cz), revealed a highly significant main effect of RESPONSE ( F (1,17) = 25.0, p <0.001), showing, as expected, a larger ERN for errors relative to fast hits.
The result was highly significant with a P < 0.001.
Baseline characteristics for nonimmune individuals (n = 1 549 989; 790 276 men [51.0%] and 759 713 women [49.0%]) are presented in Table 1 , for whom a clear trend can be seen toward lower mean (SD) age (51.6 [17.7] years vs 27.3 [15.5] years for 4 immune family members; P < .001), fewer medical diagnoses (myocardial infarction: 30 554 [2.0%] vs 3 [0.4%]; P < .001), lower mean (SD) income (€29 247/US $34 671 [€80 770/US $95 750] vs €9205/US $10 912 [€14 242/US $16 883]; P < .001), and a lower proportion of individuals who were born in Sweden (1 267 527 [81.8%] vs 534 [72.7%]; P < .001) as the number of immune family members increased.
On Unity Answers, the number of active users showed an initial growth until 2014 ( p < .001) and a decreasing trend from late 2017 until early 2020 ( p < .001).
Root dry weight Salinity, treatment, and genotype all had a significant impact on root dry weight; all interactions were highly significant ( p < 0.001; Figure. 8 ).
A consistent framing message by the camp can thus have a substantial and highly significant ( p < .001 in Model 6) effect on preference attainment for individual advocates.
Indeed, a highly significant inverse correlation between the MTA3 and SOX2 levels ( r 2 = 0.534, P < 0.001 and r 2 = 0.624, P < 0.001, respectively; Figures 3B,C ) was observed.
Even though these values indicated a modest amount of agreement between the initial perceptual classification and the HCA classification, all were highly significant, suggesting that the observed levels of agreement were not accidental (2 clusters: z (κ/σ = 128.74, p < 0.001; 3 clusters: z (κ/σ) = 105.51, p < 0.001; 4 clusters: z (κ/σ) = 100.84, p < 0.001).
There was a highly significant association (P<0.001) between sex and place of tobacco use.
Quantification of ALDH+ area fraction confirmed a highly significant reduction in mice treated with the telomerase inhibitor as compared to controls (p < 0.001) (see additional file 2 , Supplementary figure 2G).
For each of the 1000 sub-sampled trials, the divide between freshwater, marine, and terrestrial environments was highly significant and explains much of the variation (ANOSIM ranges: p = 0.001 to 0.005 and R = 0.65 to 0.60).
The difference in median viral load between carriers at age 5–9 yrs and at subsequent ages was highly significant (p < 0.001).
Increased sunniness had a highly significant effect on the rate of bumblebees reported (P<0.001; Fig 3C ); with an almost doubling for counts taking place in full sun compared to counts taking place during no sun.
In the three-way ANOVA grain Fe content and grains per spike showed highly significant (p < 0.001) interactions of genotype × treatment × year.
Nuclear size, nuclear texture, and nuclear density parameters were highly significant in differentiating between benign and malignant cases ( P < 0.001 for all of them).
Chicago: SPSS Inc.) P value is considered very highly significant if P < 0.001.
Multivariable Cox regression analysis confirmed a highly significant association between the risk classification and erectile dysfunction recovery ( P < 0.001).