Excerpts

This is striking because our statistical analyses show that overlap between groups is highly significant ( P value ≤10 −10 ) ( Fig. 5 ), so the probability of identifying 24 genes by random chance is very low.

Numbers in bold indicate highly significant partial correlations ( P < 1 e - 10).

The logistic regression and Cox models adjusted for tumour size were also consistent with a highly significant difference between the two groups ( P <10 −10 ).

Relatively large and highly significant interaction effects were found in the gradients of WF ( β PD = 0.46, 95% CI = [0.33, 0.59], P < 10 −10 ) and R2* ( β PD = -0.47, 95% CI = [−0.63, -0.32], P < 10 −7 ).

Initially, we restricted our study to SNPs present in both studies with highly significant p -values for T1D and RPS26 eQTL ( p < 10 −10 in both cases).

This difference was statistically highly significant ( p < 10 −10 ).

The difference between the total scores of the study population (29) and the norm population in 1988 (35.79) was highly significant ( p < 10 −10 ) [ 1 ].

3a ), with the logarithm of exogenous cAMP concentration a highly significant predictor of average capsule thickness ( P < 10 −10 ).

The overall statistic is highly significant ( p < 10 −10 ) for the first three eigenvectors but insignificant for the fourth ( p = 0.97), indicating that this eigenvector is capturing population subdivision that is different from the traditional western/central/eastern/bonobo designations.

We computed estimated axon conduction velocities from diameters of myelinated and unmyelinated fibers 28 along the proximal to distal axis and observed a strong and highly significant correlation (Fig. 2g , r 2 = 0.83, p < 10 − 10 ).

The difference in the number of apoptotic cells between active and inactive testes of this species was highly significant (active: 5.2 ± 10.7 cells/0.5 mm 2 ; inactive: 169.9 ± 38.4 cells/0.5 mm 2 ; Wilcox test, p = 1.03 × 10 −10 ; Figure 5 E).

Nevertheless, a highly significant, positive correlation, was found between the qPCR and RNA-seq analyses (r = 0.91, P = 1.07 × 10 −10 ; Fig. 5e ), which supported an overall concordance between the results of the two techniques despite the low replicate number for RNA-seq analysis.

For PLINK, a single SNP was deemed marginally significant if it belonged to a epistatic pair with a p-value below the genome-wide threshold P = 1.09 × 10 −10 (i.e.

Results Case-control comparisons showed highly significant mean group differences for accuracy ( p = 1.1 × 10 − 10 ), with an effect size (Cohen’s d = 1.6), more than twice as large as the mean effect size reported in a previous meta-analysis (Uljarevic and Hamilton, 2012, J Autism Dev Disord ).

Consistent with these observations, gene signature–based deconvolution of cell types by xCell ( 24 ) showed highly significant enrichment of immature dendritic cell (iDC) signatures in the normal nasopharynx compared with epithelium from other upper airway sites including the tonsil ( P = 1.11 × 10 −10 ; fig.

Although heterogeneity of response was observed in different cells, the finding that 10 significant cells out of 18 at p < 0.05 was highly significant at the population level (binomial test; p = 1.12E−10; n = 18 recordings from 7 animals).

Analysis of a deposited EWS dataset generated by Savola and co‐workers 48 using the SurvExpress tool 49 showed highly significant separation (hazard ratio 8.99; P = 1.128 × 10 −10 ) of the overall survival of EWS patients into low‐ and high‐risk groups based on the expression of PHGDH , PSPH , PSAT1 , SHMT2 , SLC1A5 , MTHFD2 , and MTHFD1L (Figure 7 G).

The difference between Shift 2 and Shift 3 was also highly significant (mean difference = 4.67, p = 1.13e-10) (Table 5 ).

Furthermore, highly significant enrichments in biological functions have been observed to be related to the immune system; for example, Inflammatory Response (p<1.15E10 −16 –2.06E10 −4 ), Immunological Disease (p<1.11E10 −11 –1.98E10 −4 ), Hematopoiesis (p<7.52E10 −28 –2.91E10 −4 ) and Cell-mediated Immune Response (p<5.87E10 −27 –2.62E10 −4 ) were frequently encountered.

The main effect for the participant group was highly significant (F(1, 332.00) = 44.29 and P = 1.17 × 10 −10 ).

Both main effects were highly significant: experiment type, F (4, 7079) = 13.13, p = 1.18 × 10 −10 , η 2 = 0.0067, and erosion method, F (5, 7079) = 95.04, p = 3.37 × 10 −97 , η 2 = 0.0603.

17 Although the computed P -value from this ES is highly significant ( P = 1.18 × 10 −10 ), such a mean increase in blood pressure may not always have clinical implications.

Some 90 independent replications of these experiments have provided evidence for a highly significant effect (overall effect size = 0.09, z = 6.4, p = 1.2 × 10 –10 ; Bem et al., 2015 ).

The overlap between DEGs and differential TADs was highly significant ( p = 1.22 × 10 −10 , odds ratio = 3.59), indicating a strong enrichment of DEGs within differential TADs.

Recently, a genome-wide association scan with a subsequent replication study involving over 67,000 individuals (7,473 cases and 42,938 controls) of European ancestry produced highly significant evidence of the strong association of a single nucleotide polymorphism (SNP) rs11177 (C/T) with severe hip and knee OA ( P value = 1.25 × 10 −10 ), a missense polymorphism within the nucleostemin-encoding gene GNL3 19 .