Excerpts

This revealed a highly significant association for rs61748181 (OR = 0.64 95% CI 0.56-0.74, P = 1.28×10 −10 ) that was stronger than that seen for rs35226131 (OR = 0.68 95% CI 0.59-0.79, P = 1.91×10 −8 ).

The two data sets show a highly significant correlation of the categorized expression changes in dauers versus mixed/adult stages for all three species ( P = 1.29 × 10 - 10 , P < 2.2 × 10 - 16 , and P = 2.72 × 10 - 8 for C. elegans , P. pacificus , and S. ratti , respectively, supplementary fig. 6A , C and E, Supplementary Material online).

SCC mec type accounted for a substantial proportion of the variation in excision frequency, with one-way ANOVA showing a highly significant effect ( F (23,48) = 8.92, p = 1.3 × 10 −10 ; R 2 = 0.8104).

5 , the correlation between the time to completion of MI and ME was highly significant in exercise 2 in the amputated group for the intact hand (Pearson’s correlation coefficient, r = 0.72, p = 1.309*10 −10 ) and in the able-bodied control group for the dominant hand (Pearson’s correlation coefficient, r = 0.59, p = 5.461*10 −15 ).

The evidence for directed migration is further supported by a highly significant Rayleigh test (p = 1.32×10 −10 ) demonstrating a unimodal deviation from uniformity or random migration in this instance.

The decrease in TLC in overweight patients was mainly due to a decrease in expiratory reserve volume (ERV) further illustrated by a highly significant ( p = 1.33×10 −10 ) correlation between BMI and ERV.

The Mann–Kendall trend test showed an increasing trend between citation density and time ( P = 1.342E-10, Z = 6.4223) (Fig. 3 ). 3.1.

The results show a highly significant enrichment of essential genes in the TPPIN (p-value = 1.37 × 10 -10 , Table 4 and Figure 5 ).

Highly significant mean R 0 differences were observed between the coalescent and BDSKY (p = 1.4E-10) estimates, as well as between coalescent and surveillance (p = 1.4E-12).

TNFSF-related eQTLs are associated with a variety of autoimmune and autoinflammatory diseases Loci near 24 % of autosomal TNFSF-related genes have been associated with autoimmune and inflammatory diseases by GWAS (Additional file 3 , “Mapped Genes” column), resulting in highly significant enrichment of these gene loci with autoimmune diseases (Fisher’s exact test p = 1.4 × 10 −10 ).

A quantitative analysis of LC3 and HSV-1-gD co-staining revealed a highly significant ( p = 1.42 × 10 -10 ) 4.5-fold increment of the Mean Colocalization Index (CI) in infected caspase-8−/− as compared to wt MEFs (Fig. 7D ).

Furthermore, at 8 dpi, Ago2 expression was even more pronounced, with a highly significant increase ( p = 1.42 × 10 −10 ), suggesting a strong activation of the RNA interference (RNAi) pathway in response to OROV infection.

The year of cultivation had a highly significant effect on all traits, with p -values ≤ 1.426 × 10 −10 , except for C18:2, which had a higher p -value of 0.014 but was still statistically significant.

The difference in mCG levels in this window between the two groups of promoters is highly significant (genes with only promoter H3.3-enriched nucleosomes compared to genes with only TTS H3.3 nucleosomes, P -value = 1.46 × 10 -10 , Wilcoxon’s rank test, one tail).

*: difference with driver alone highly significant ( p<1.5 10 −10 , T Test). **: difference with driver alone significant ( p = 0.03 , Fisher's exact test); ***: difference with driver alone highly significant ( p<0.005 , Fisher's exact test).

From the genome-wide binomial test, C1orf127 showed highly significant enrichment for damaging RGs (enrichment = 176.8, P = 1.5 × 10 −10 ; Fig. 1 A ) and a greater enrichment for LoF RGs (enrichment = 392.4, P = 2.6 × 10 −12 ; SI Appendix , Fig.

However, we also identified other highly significant targets, such as GDP dissociation inhibitor 1 (GDI1; P = 1.54 × 10 −10 ) and SPARC-related modular calcium binding 1 (SMOC1; P = 6.93 × 10 −9 ).

Nevertheless, we observed a highly significant, monotonic correlation between the length of differentiation of the hCS in vitro and their predicted methylation age (r = +0.76, p = 1.57e −10 ; Figure 1a ), consistent with continuous and progressive maturation of these cultures over time.

The sex-stratified meta-analyses (Supplementary Data 4 ) showed nominally significant sex-heterogeneity ( P het = 0.02) for the lead SNP (rs6471570) in the CYP11B1 locus in boys ( β = 0.20; P = 1.7 × 10 −10 ) and girls ( β = 0.10; P = 0.001).

A highly significant overlap was found ( P = 1.73e-10).

First, smokers had a highly significant ( p = 1.8 × 10 −10 ) increase in the peripheral CD3 + T cells expressing GPR15 (15.5% in smokers vs. 3.7% in non-smokers), and to a lesser extent B cells, and second, these GPR15 + CD3 + T cells had a markedly lower average methylation of cg19859270 than GPR15 − CD3 + T cells, resulting in the arithmetic difference in mean methylation at cg19859270 observed in whole blood.

This was highly significant ( p = 1.84 × 10 ‐10 , Figure 5J ), indicating that clustering and colocalization of telomeres with 53BP1 damage foci normally occurs as cells senesce.

In the model fitted to untransformed RMS values, the main effect of diameter was not significant ( χ2 = 0.93, df = 3, p = 0.820), the main effect of depth was borderline ( χ2 = 6.70, df = 3, p = 0.080), and there was a highly significant diameter-by-depth interaction ( χ2 = 56.89, df = 6, p = 1.9 × 10−10).

The likelihood-ratio test gave a highly significant result (likelihood-ratio statistic was 48.22149, P = 1.9 e-10).

Mean current density had a highly significant relationship with estimated abundance of dragonflies (R 2 = 0.58, p = 1.92 × 10 –10 , Fig. 2 a).