Excerpts

In hypoxia, 19 ± 9% of motile mitochondria showed anterograde movement in shRNA-transfected cells, whereas 79 ± 6% showed retrograde movement, a highly significant difference (P < 0.001, t test; n = 5; Fig. 10 C ).

Similarly, there was an increasing trend in the total PQ base dosage administered (242.6 ± 79.7 vs. 265.7 ± 92.3 mg, P < 0.001), despite no significant differences in total weight-based PQ base dosage administered (3.38 ± 1.1 vs. 3.64 ± 1.3 mg/kg, P = 0.256) or the proportion of patients in the underdosing group (< 3.5 mg/kg; 296 [73.6%] vs. 167 [68.2%], P = 0.135] between the two periods.

pre-term cohorts using the Kolmogorv-Smirnov asymptotic-test we found that for in term children the effect is highly significant (in term KSa = 2.35, p < 0.001) and for pre-term children it is not significant (pre-term Ksa = 0.73, p > 0.05).

Carbachol treatment resulted in a highly significant depression of field EPSP responses ( t (16) = 6.60, P < 0.001).

Test for trends over increasing age-groups, revealed highly significant trends (p ≤ 0.001) in all cortisol variables but morning cortisol in women (p = 0.215) and Δ-cortisol in men (p = 0.088).

Model fitting comparison The fitting results of both MLR and RF showed that all variables appeared as highly significant ( p < 0.001) in the intermediate models.

In-hospital mortality rates for patients with hypertension, DM, LC, CKD, and malignancy were 25.5%, 25.2%, 34.5%, 28.0%, and 33.3%, respectively, showing a decreasing trend over time ( P < 0.001).

Most of these associations were highly significant, with a P value of < 0.001, as shown in Table 10 .

Osteocalcin displayed highly significant negative correlations with HbA1c (r = − 0.309, P < 0.001), CRP ( r = − 0.327, P < 0.001), FBG ( r = − 0.191, P = 0.031), IL-6 ( r = − 0.227, P = 0.010), and TNF-α ( r = − 0.184, P = 0.037).

Combined data from all the three studies showed a trend for a correlation between high OPN expression and high tumor TNM stage (III and IV) (OR =2.57, 95% CI 1.61–4.11, P <0.001) ( Figure 4 ) without any heterogeneity ( I 2 =0%, P =0.417).

This first stage of analysis also indicated that the best explanatory variable for location was study area versus whether the area was north or south of I-80, although both were highly significant (p = 0.001; Table H in S3 Appendix ).

There is a highly significant negative trend over time in the proportion of remaining founder alleles, but the variation among breeds is quite large ( b = -0.012, r 2 = 0.42, P<<0.001; Fig 3 ).

The DIASS showed good internal consistency (Cronbach’s alpha = 0.86), and a good concurrent validity as shown through the highly significant association between forensic experts’ judgment reached using the DIASS and the court ruling on the real cases (rho = 0.674; p < 0.001).

Analysis of covariance indicated a highly significant difference in the slope of the trend line from 1985 to 1999 as compared to the trend line from 1999 to 2005 (p < 0.001).

Before fasting, PCSK9 exhibited a highly significant ( p < 0.001) moderate positive correlation with FBG ( r = 0.40), and weak positive correlations with TG ( r = 0.28) and HOMA-IR ( r = 0.35).

However, the latitudinal trend of WGD was positive and highly significant for sequence diversity ( r = 0.285, p < 0.001, Table 3 ) but negative and not significant for gene diversity ( r = -0.017, p > 0.05, Table 3 ).

A highly significant increase in pretreatment PSA levels was observed among prostate cancer cases ( p < 0.001; Table 1 , Fig. 1 A). 3.2.

The QTL on the bottom of chromosome 5 revealed a clear G × P interaction, as it was highly significant in the monoploids ( p < 0.001) while it was not detected in the diploid generation ( p = 0.642).

The correlation between BED and psychiatric disorders was highly significant ( p <0.001) for all psychiatric disorders (Table 4 ).

According to ANOVA, the chosen regression model was highly significant: F (6, 402) = 31.4, p < 0.001.

The difference was regarded as significant when P < 0.05 (significant), P < 0.01 (moderately significant) and P < 0.001 (highly significant).

When fluorescence intensities from the six sampling events were combined and plotted against FIB concentrations, relationships between FIB and fluorescence concentrations were highly significant for TRP and CDOM from both the sonde and benchtop instruments (p < 0.001; Fig. 5 ).

The effect was highly significant under a binomial test at the group level ( p < 0.001 for all spatial frequency combinations) as well as at the individual level ( p < 0.001 for all observers).

The p -values obtained for communication/public relation skills, marketing of health services, change management, law, ethics & code of conduct were highly significant ( p -value < 0.001).

Fishers exact test showed that the relationship between nonspecificity and inhibition was highly significant (p << 0.001) and that conventional primers produced significantly more nonspecificity (p = 0.008) and inhibition (p = 0.002) than did HAT-PCR primers.