The tests for heterogeneity were highly significant [ALT (I 2 = 84.2%, P < 0.001) and AST (I 2 = 75.7%, P < 0.001)].
Excerpts
Results A highly significant correlation between the mRNA expression levels and protein levels of KLK5 in tumor tissues was observed (r s = 0.683, p < 0.001).
Indeed, an analysis using the rate of button presses (and thus the variable that correlated to average distance to target during probe trial) in all trials as a predictor variable for EEG activity in all corresponding trials revealed a highly significant ( p < 0.001) negative correlation with alpha-activity, involving large parts (probably due to the effect size) of left parietal and motor cortex and of occipital cortex ( Figure 4(e) and ( f )).
Differences with p < 0.05 are considered statistically significant, differences with p < 0.01 are considered highly significant, and differences with p < 0.001 are considered extremely significant.
The trend toward housing improvement was also expressed in the highly significant drop in houses having tarred-cardboard roofs, from 52.9% to 31.6% over 0–78 MPS (χ 2 = 40.5, df = 2, p < 0.001), which were replaced by corrugated metal-sheet roofs ( Table 2 ).
37 Yaman Agaoglu et al found that the differences in miRNA plasma levels between the healthy controls and the patients were highly significant for the miR-21 ( P <0.001) and -221 ( P <0.001) but not for the miR-141( P =0.23). 38 An analysis of 742 miRNAs using plasma-derived circulating microvesicles (cMVs) from 78 PCa patients and 28 healthy individuals identified differentially expressed miRNAs that included upregulation of miR-107, -130b, -141, -2110, -301a, -326, -331-3p, -432, -484, -574-3p, and -625 and downregulation of miR-181a-2.
Rasburicase produced a highly significant (p < 0.001) decrease in UAL within 24 hrs after the first injection (group 1: 0.51 ± 0.39 mg/dL, group 2:1.83 ± 1.07 mg/dL) with a response rate of 100% and 93% respectively.
Snow cover was highly variable, but did not show a significant trend over time (parametric coefficients: estimate 7.42 ± 0.93, P < 0.001; smooth term: F (25,29) = 2.72, P = 0.062; R 2 = 0.217; Fig. 1 b).
The reliability of RNA-seq data was validated by qRT-PCR detection of 10 randomly selected up- and down-CRGs using gene-specific primers ( Supplementary Table S1 ), showing a highly significant correlation (R 2 = 0.96, p < 0.001) between the results of RNA-seq and qRT-PCR ( Figure 2 C,D).
Another study reported a positive trend across quintiles of total sugar intake in the overall study population ( p < 0.001) and across sex and age subgroups except for two null associations with calcium intake for males aged 19–30 years and 31–50 years [ 36 ].
The sensitivity of CHIKV E2 envelope protein was higher than that of CHIKV E1 envelope protein, even though there was a highly significant correlation in the seroreactivity between CHIKV E1 and E2 envelope protein for anti-CHIKV positive serum samples ( p < 0.001).
Regarding oocyte retrieval, breed had a highly significant ( p < 0.001) impact on the number of total COCs, available COCs, and grade A COCs per ewe ( Table 1 and Table S1 ).
In men masculinity and femininity self-ratings showed a highly significant negative interrelation ( r = −0.55, p < 0.001).
Archaeal and bacterial communities were significantly associated with BMRG community structures in both autumn and winter ( p < 0.001), whereas the association between MGEs and BMRGs increased from a marginal relationship in autumn ( p = 0.046) to a highly significant relationship in winter ( p < 0.001).
In cases of HPV 58 single infection, a more highly significant progression rate, compared to other high-risk types, was observed at 6 months (relative risk [RR], 3.3; 95% confidence interval [CI], 2.04 to 5.30; p < 0.001) and 12 months (RR, 5.03; 95% CI, 2.56 to 9.91; p < 0.001).
Findings: The extract showed highly significant ( P < 0.001) analgesic activity with % inhibitions of writhing response at doses 200 and 400 mg/kg body weight were 77.86% and 71.25%, respectively.
The DPPH scavenging activity was significantly ( p < 0.05) correlated positively with TFC and displayed an extremely significant ( p < 0.001) positive correlation with TPC.
The fact that rrTNBC versus srTNBC differences in median DFS, PFI, PRS, and OS remained highly significant (all p < 0.001) in both the overall cohort and the platinum-subgroup indicates that the prognostic impact of the rrTNBC phenotype is robust and independent of treatment line or regimen selection.
The regression was highly significant, F (2,108) = 1490, p < .001, R 2 = .965.
Five studies, 7 studies, 5 studies, 12 studies, 17 studies, 7 studies, and 2 studies were included to assess the effect of treatment on blood glucose levels at 1 week, 2 weeks, 3 weeks, 1 month, 2 months, 3 months, and 6 months, respectively, all of which showed a highly significant hypoglycemic effect in the MSC-treated group (1 week: SMD = − 1.484, 95%CI − 2.586 to − 0.381, p < 0.001; I 2 = 80.6%; 2 weeks: SMD = − 2.312, 95%CI − 3.743 to − 0.882, p = 0.002, I 2 = 89.6%; 3 weeks: SMD = − 4.007, 95%CI − 6.472 to − 1.541, p = 0.001, I 2 = 92.1%; 1 month: SMD = − 1.740, 95%CI − 2.660 to − 0.821, p < 0.001, I 2 = 83.8%; 2 months: SMD = − 1.830, 95%CI − 2.633 to − 1.028, p < 0.001; I 2 = 86.0%; 3 months: SMD = − 1.649, 95%CI − 2.838 to − 0.461, p = 0.007; I 2 = 84.6%; 6 months: SMD = − 3.045, 95%CI − 5.895 to − 0.195, p = 0.036; I 2 = 76.4%).
Highly significant ( P < 0.001) differences were observed among treatments for plant height (PH), panicle length (PL), number of the total spike (NTS), shoot dry weight (SDW), grain yield (GY), and straw yield (SY).
As shown in Figure 5A , the expression level of TMSB4X showed an increasing trend as the WHO classification level increased ( p < 0.001), and in addition, it was higher in patients over 60 years of age ( p < 0.001, Figure 5B ).
The differences of total extractives content between the two species were not statistically significant ( P = 0.254) but the site had a highly significant effect ( P < 0.001) with the trees of both species of site 2 being different from those of sites 1 and 3.
The effects were examined across four major categories: grain physical characteristics, cooking and processing properties, nutritional components, and mineral and vitamin content. In respect to the grain physical characteristics (Table 2 A), the genotypic effects were highly significant ( p < 0.001) for all physical traits, with notably high mean squares for milling (21.46) and brown rice (18.99).
The Welch ANOVA results revealed highly significant differences ( p < 0.001) in the three main phenological dimensions and in bud dormancy (EF010), confirming that each phenological module responds differently to local environmental conditions.