Excerpts

All of these predictors gave highly significant ( P < 10 -8 ) improvements over random pairs.

All enrichments for GO ontologies representing these six biological processes were highly significant; P <10 −8 .

In cross 2, in which the EJ1 chromosome was present and the HR-h pathway was available, we saw highly significant decreases in HR-h repair in brca2 mutants ( P <1e −8 ) ( Figure 1 B).

Cellular RNAs that increased in concentration slowly and steadily throughout most of the observed infectious cycle, which are grouped in cluster 5, exhibited a highly significant enrichment in RNAs specifying proteins that participate in the establishment and maintenance of chromatin structure ( P = 10 -8 ).

Of these events, 17.2% presented in patients in the icosapent ethyl group, and 22.0% in individuals in the placebo group, a highly significant difference [hazard ratio 0.75, 95% confidence interval (CI) 0.68–0.83; P = 0.00000001]; the RRR was 25%.

This enrichment is highly significant ( p = 1 × 10 −8 ), especially when considering that all miRNAs may not necessarily disrupt transcript levels.

Paired statistical tests across all datasets indicate that these improvements are highly significant ( p < 1 × 10 −8 ).

4b and Supplementary Data 2 ), which is highly significant (Binomial Test P -value < 10 −8 ) and suggestive of their functional importance.

Notably, the gene candidates THBS1 and IL18RAP exhibited highly significant upregulation (LogFC > 1.9, p < 10−8) in the independent GSE28750 cohort, confirming that our network-based prioritization captures clinically relevant expression changes.

Compared to peaks containing L-CTCF-BSs, P-CTCF-BSs exhibited a higher mutation rate of 1.34 and 1.25 times per CTCF-BS for LNCaP and MCF7 respectively ( Supplementary Table S4 ), and the elevated rate is highly significant ( P -value < 1 × 10 −8 ) as determined by a permutation test (Materials and methods) (Figure 2A , B ).

Furthermore, a highly significant association was found between the presence of the T allele and increased risk of lung cancer (p = 0.00000001), and the results are shown in Table 2 and Figure 1 .

Both the integrated fluorescence intensities, which represent the amount of DNA per nucleoid ( Figures 3B,D and Table 1 , columns 11 and 12), and the measurements of nucleoid lengths ( Table 1 , columns 13 and 14) indicate that the difference in DNA between small and large deeply-constricted cells at the fast growth rate is highly significant ( p < 10 -8 , as determined by a two-tail t -test); at the slow growth rate, the difference remains significant, but just barely ( p = 0.035).

While we found no obvious and consistent correlations between GWAS gene significance and FCs (electronic supplementary material, figure S4 a–g ), we identified GRIN2A and KCNB1 with highly significant GWAS associations ( p < 10 −8 ) in all seven diseases, and more strongly upregulated TL (FDR < 0.05, log 2 FC (TL/FL) > 1) in either both INH/EX ( GRIN2A ) or in INH ( KCNB1 ) ( figure 1 f,h ).

Most regions demonstrated significant heritability contributions to KC, particularly chr8:79,756,170–81,340,231, which exhibited highly significant h2 across KC, AD, AC, and AA (all P < 1 × 10−8).

All of these regions showed highly significant associations (− log 10 P value > 8**) at the developmental stages after AP (i.e.

PTPRD Many of the GWA studies discussed previously in this review identified clusters of SNPs with nominally significant associations (10 −2 > p > 10 −8 ) with drug dependence and addiction-related phenotypes [ 6 – 8 , 85 , 88 , 91 , 92 , 117 – 120 ].

All of the heritability and correlation estimates were highly significant ( p < 1 × 10 −8 ).

Welch’s t -tests yielded directionally consistent and highly significant differences (e.g., Depression p ≈ 1.0 × 10 −8 ).

Serum levels of 10 biomarkers correlated (r > 0.2, P < 0.05) with the level of fT4 and 12 with the level of TRAb (Supplementary Table). Six biomarkers showed a highly significant increase ( P < 1 × 10 −8 ) between patients with GD and HS ( Fig. 2 ), most significant for TNF receptor superfamily member 9 (TNFRSF9).

A highly significant relationship was observed between cytokinin dose and GUS activity ( n =119, F =37.99, P =1.02 × 10 −8 , R 2 =0.24) ( Figure 6C ).

This overlap between FMCD genes and the cilia disassembly pathway identified here is highly significant ( P = 1.06 × 10 −8 , Fisher’s exact test; Fig. 5A ), prompting further investigation.

Of these, 19 were expressed in platelets, and String analysis showed a highly significant PPI enrichment ( p = 1.08e- 08).

The correlation between lineage and average sperm length for all 33 males was highly significant (r = -0.811, n = 33, t 31 = 7.71, p = 1.1E-8).

A Kruskal-Wallis test showed a highly significant difference in water collection times between the kebeles in both wet season (chi-squared = 40.0, p = 1.1 × 10 −8 ) and dry season (chi-squared = 42.3, p = 3.5 × 10 −9 ) ( Fig. 3 ).

As expected, a two-sample t -test performed on these raw data confirmed that there was a very highly significant difference between the mean whole-blood HbA1c levels of these two groups ( p = 1.11 × 10 −8 ), with the T2DM one being much greater.