Excerpts

Univariate analysis was performed to identify independent predictors of edema and the volume of filler administered was highly significant ( P < 0.00001, Fig. 5 A).

Similarly, the liraglutide versus placebo/standard treatment subgroup (Figure 4 ) showed a highly significant reduction in BMI (MD: −1.75 kg/m2; 95% CI: −2.38 to −1.12; p < 0.00001), again with no heterogeneity (I2 = 0%), reinforcing the reliability of liraglutide’s effect in weight reduction.

Only highly significant meta-analysis results (p-values <0.00001) were used to select a subset of SNPs – AD-associated genes confirmed by numerous studies [17] .

Similarly, in FA3, the ettringite content showed highly significant increases from 0.03% to 0.24% by aging (Z = 11.24, p < 0.00001).

Results: A strong and statistically highly significant (r=0.98; p<0.00001) Pearson’s correlation was found between bone age assessed from hand-wrist radiographs using Björk’s method and bone age assessed from cephalometric radiographs using the method by Baccetti et al.

There was a highly significant correlation between both dynamics rates (R = 0.769, p < 0.00001).

We found highly significant overlaps (p<10 -5 ) for three of the factors (Egr2, Irf8, and Sp4) that exist in both datasets, and a border-line significant overlap for the fourth (Smarca4), validating the quality of the edges in our network.

The power of the TCI to predict the membership of individuals in a particular rsFC group (i.e., squared multiple regression R 2 ) was strong and highly significant for group 1 (R 2 = 52%, F = 79.42, p < 1E−5, RMSE 0.11), group 3 (R 2 = 67%, F = 142.9, p < 1E−5, RMSE = 0.07), group 4 (R 2 = 35%, f = 51.2, p < 1E−5, RMSE 0.17), and group 5 (R 2 = 46%, F = 7 l.9, p < 1E−5, RMSE 0.14).

All the variables included in the model were highly significant at a p<0.00001 ( Table 2 ).

Of these, five genes ( atp H, ndh K, psb E, rps 11, and rps 4) displayed highly significant variation ( P < 0.00001).

longicornis ticks were treated at − 4 °C, 0 °C, and 8 °C, the HlAQP2 showed a decreasing trend ( p < 0.00001) in the first 3 days and then increased ( p < 0.001).

T-test statistically confirmed the highly significant response of M2e ELISA test to live virus infection at p = 0.00001(data not shown).

In addition, twelve of the significant SNPs in the NHGRI Family Cohort were borderline significant in the meta-analysis ( P < 1 × 10 − 5 ) (Table 3 , Figure S2), of which eight had homogeneous effects in both cohorts ( P het > 0.1).

Highly significant inter-study heterogeneity was noted (I 2 = 85%; χ2 p= 0.00001).

All p -values were highly significant ( p <0.00001, Table S2 ).

4 ), resulted in PSSMs showing a highly significant pattern of selective positions indicative of the presence of antibody epitopes ( p < 0.00001, ANOVA); 95% of these epitopes appeared fully contained within the 15-mer stretch selected for the fine specificity analysis, whereas the remaining 5% extended to the N- or C-terminus of the selected 15-mer stretch and could potentially extend even further.

When stratified by energy source, laser-based ERBT showed a profound and highly significant reduction in obturator nerve reflex compared to cTURBT (OR = 0.04, 95% CI: 0.02–0.08; P < 0.00001), with no heterogeneity (I 2 = 0%).

As expected from the voxel-wise analysis, all the regions of interest (AI, OP3, OP4, OP8, PIC, PIVC) show highly significant activations in the “Visual + vestibular” > “Visual only” contrast, with FDR adjusted p values < 10 −5 in all cases (Fig. 3 b).

The difference between the TYP and SHA lineages based on the full concatenate (including the three gene regions, rbc LS, COI , and ITS ) is highly significant ( F st = 0.9949, P < 0.00001); the total sequence divergence ( D xy ) between the lineages is 0.0261 (ignoring indels).

This comparison clearly demonstrated that CSC-affected eyes had SFCT which was ~145 μm (34%) bigger compared to normal control’ eyes (weighted mean difference (WMD) = 145.03, 95% confidence interval (CI), 121.33–168.73) and that this difference was highly significant (P<0.00001), with heterogeneity identified.

Chlorophyta and Toxoplasma seem to have a significant positive influence on each other ( P < .01), whereas Dictyostelium and Plasmodium seem to have a highly significant positive influence on each other ( P < 10 −5 ).

The correlation between the initial decision and Δ f is highly significant (Spearman’s correlation: |ρ| = 1; p < 10 −5 ).

Here, we detected a total of six highly significant association signals ( p < 1 × 10 −5 ) for i-LT, corresponding to five unique genes, consistent with a previous report ( Supplemental Table 7 ) ( Wei et al., 2018 ) and suggesting the potential importance of these candidate genes for final PH in maize.

The association of these macrophages with Hodgkin lymphoma is highly significant compared to biopsies for nonneoplastic conditions ( P < 10 −5 ), and the other malignancies examined ( Figure 3 ).

Highly significant differences were observed between susceptible and resistant UTI groups ( p = 0.00001 and p = 0.000015, respectively), indicating BCG cycles as a key differentiating factor.