Excerpts

Linkage disequilibrium and haplotype analysis The LD test revealed that LD was moderately significant between T182C and A3081T (|D'|=0.702, r 2 =0.275, p-value=<10 -5 ) but not between A3081T and G1287A or between T182C and G1287A ( Table 5 ).

We tested the five significant or marginally significant SNPs (p < 10 −5 ) using standard linear regression models adjusted for the same covariates as above ( S1 Table ).

Four SNPs showed associations with post-RT pain at the marginal significance level of p < 1 × 10 −5 ; rs16970540 in ring finger and FYVE-like domain containing E3 ubiquitin protein ligase ( RFFL) or near to DNA ligase 3 ( LIG3 ) gene ( p = 1.7 × 10 −6 ), rs4584690, and rs7335912 in ATP-binding cassette, sub-family A, member 4 ( ABCC4)/ multidrug resistance protein 4 (MRP4) gene ( p = 5.5 × 10 −6 and p = 7.8 × 10 −6 , respectively), and rs73633565 in epidermal growth factor-like protein 6 ( EGFL6 ) gene ( p = 8.1 × 10 −6 ).

The presence of clustered breakpoints on a per-chromosome basis 13 : chromosomes that had a highly significant non-random distribution of breakpoints with a stringent threshold of P < 10 −5 were considered to be clustered.

To identify independent signals per locus we applied linkage disequilibrium (LD) clumping (‘-clump’ from PLINK 2.0) for all nominally significant single nucleotide polymorphisms passing P < 10 –5 using the corresponding study sample set for calculating LD.

We found that the cure rate and the effective rate of the combination therapy was much higher than that of NB-UVB alone (the between-group difference was markedly significant (OR = 3.34, 95% CI: 2.04–5.48, and P < 0.00001 and OR = 5.04, 95% CI: 2.65–9.57, and P < 0.00001, resp.).

Besides, we use the Pearson Chi-Square test to evaluate the distribution of FIGO stages I, II, III, IV among expansile and infiltrative tumors, and found there was a highly significant association between tumor type and FIGO staging (Pearson chi2(3) = 110.9206, p <0.00001) Figure 4D . 3.3.4 Publication bias Publication bias was investigated by Begg’s funnel plots.

Age showed a trend for association with individuals with both diseases (p = 0.00001; OR = 3.6, 95% C.I. 0.9-10.7) and chronic periodontitis alone (p = 0.002; OR = 3.0; 95% C.I. 0.8-10.52), suggesting that the difference in the distribution of BRINP3 alleles between healthy and individuals affected by peri-implantitis is confounded by the difference in the age of both groups (healthy individuals were on average 8 years younger than the affected individuals; Table 1 ).

And finally, when comparing JN and A-VMN directly using the blow-by method of delivery, a 6-fold increase in the mass of drug was found ( Table 2 ) ( p = 0.01567), with a highly significant lower residual volume in the A-VMN also observed ( p = 0.00001).

This superiority of RBZ and RBZ + Laser compared to laser treatment in terms of a positive effect on BCVA were highly significant (WMD = 5.65, 95% CI, 4.44–6.87, P<0.00001 and WMD = 5.02, 95% CI, 3.83–6.20, P<0.00001, respectively), with no heterogeneity identified ( Fig. 2A and 2B ).

Heterogeneity analysis revealed highly significant heterogeneity (I 2 = 93%, p < 0.00001), thus a random-effect model was used for statistical analysis.

In all cases, the computed correlation coefficients turn out to be very highly significant ( p < 0.00001).

SNPs with a call rate lower than 0.9, a minor allele frequency higher than 0.005 and a highly significant deviation ( P < 10 -5 ) from the Hardy-Weinberg equilibrium, and SNPs that were not annotated (UMD3) on the autosomes or on the pseudo-autosomal region of the X-chromosome were excluded from the analysis.

There was very highly significant difference in the marital status of the two groups of study p=0.00001; HIV+ve had more divorcees and widows than HIV-ve (8.6% vs 1.9%), (25.7% vs3.8%) respectively and 88.9% (n=24/27) of the HIV+ve widows testified that their husbands died of HIV infections.

Simple (paired t -) tests showed for the comparison of Fabrics 1 and 2 (the least and second least liked) a highly significant difference (t = -6.8, p < 10 -5 ), whereas Fabrics 3 and 4 (the second most and the most liked fabrics) were not significantly different ( t = -1.0, p > 0.1) and ratings for Fabrics 2 and 4 were just significantly different ( t = -2.3, p < 0.05).

For the third most significant genotyped loci, located on chromosome 8 in the vicinity of the ZNF704 gene, borderline significance was achieved ( P <10 −5 ).

A highly significant positive correlation was found between the weight of male newborns and their mother’s weight ( r = 0.389; P = 0.00001), while no significant correlation ( r = 0.180; P = 0.0871) was found between the weight of female newborns and the weight of their mothers (Figure 1 ).

Estimation of the SNP effect from the haplotype effect Under the hypothesis that one SNP of each haplotype was expected to have a major effect on the recorded trait, direct observation of those haplotype alleles that showed a highly significant effect (P < .00001) on one trait allowed to select one SNP where the two alleles showed opposite effects on that trait.

Also, the random effect of study was highly significant for the half‐life analysis ( p < 0.00001), but there was no significant random effect of study for the percent recalcitrance model ( p = 1).

Table 2 shows the intergroup and intragroup comparisons between Group A and Group D using one-way analysis of variance wherein a significant difference was observed between all four groups when intergroup and intragroup comparisons were made, while the results were found to be statistically highly significant ( P < .00001).

Similarly, Table 3 shows the multiple comparison using Dunn’s multiple comparison test with the results being fairly significant ( p < 0.001) for the Watch–Access pair, very highly significant ( p < 0.00001) for the Watch anti-TB without duplicates pair, and highly significant ( p < 0.0001) for the Watch anti-TB (all) pair.

That study uncovered single highly significant effect ( p = 0.00001) showing ADHD adults had increased rightward P8–P7 beta2 asymmetry during the CPT, and in post hoc analysis confirmed that this result was specific to the beta2 frequency band.

Subgroup analysis of six studies with higher cumulative dose of statin use, defined as statin use over 180 cumulative defined daily doses (cDDDs) or 0.5 years (cumulative duration), showed a trend towards more risk reduction of liver cancer (RR=0.53, 0.36 to 0.79), but with a high degree of heterogeneity (I 2 =90%, p<0.00001; see online supplementary figure S7).

Group differences were highly significant at the overall p = 0.00001 level.

There was a go highly significant ( p = 0.00001) prevalence of Nab against NFL, IgM and IgG, as well as NFH and GFAP, IgG in MCI patients.