Excerpts

A correlation matrix was calculated for these genes, using Pearson Product-Moment Coefficient, defined as r x , y = ∑ i = 1 n ( x i − x ̄ ) ( y i − y ̄ ) ( n − 1 ) δ x δ y The values of Pearson correlations above 0.3 are statistically highly significant (p-value < 0.00001 after Bonferroni correction for multiple testing [ 85 ]).

Meanwhile, the triple interaction between OV, dwell-time advantage, and TMS condition remained highly significant ( β = –0.710, CI = [–1.019,–0.401], p = 10 –5 ).

Using fixed-effects model, the results showed that the patients with hypothyroidism had a marginally significant reduction in CI compared with healthy controls (WMD=-0.53, 95%CI[-0.65, -0.41], P <0.00001), and heterogeneity analysis showed large heterogeneity (Tau2=0.21, Chi2=44.02, P < 0.00001, I 2 = 93%).

When the blind evaluator rated photos, there was a slightly smaller but still highly significant decrease in score (−1.1) from day 0 to day 360, t(36) = −10.712, p < .00001] with no significant decrease in effect from day 60 to day 360 in most patients as can be shown in Figures 2 – 4 below, with the minority of patients having minimal regression, Figures 5 – 7 .

All differences were statistically highly significant ( p < .00001).

The unpaired Student’s t-test revealed a highly significant difference in PNP biodegradation between the compared conditions, with a p-value < 0.00001, indicating statistical significance well below the 0.01 threshold.

Not surprisingly, the effect of motion direction was highly significant (t(17)=21, p<10 -5 ).

The differences are relatively constant across the subjects, and a paired student's t test returned a highly significant difference between the two conditions (P < 10 −5 ).

The comparison between the IUGR group and other patients regarding abnormalities in UA PI was highly significant ( P value < 10−5); 13 out of 60 individuals in the IUGR group had UA PI above the 95th percentile, compared to only 1 out of 100 in the other patients.

Differences between collaborative cross strains in total luciferase expression were highly significant (F 11,44 = 9.64; p < 1 × 10 −5 ).

The test for overall effect was highly significant (Z = 7.99, p < 0.00001), confirming the beneficial impact of the interventions on PFS.

In fact, the largest schizophrenia GWAS to date found SNPs in three genes ( CACNA1C , ITPR3 and CYP2D6 ) within the serotonergic synapse pathway reached GWAS significance ( P <5 × 10 −8 ) and SNPs in another 17 genes within this pathway were nominally significant ( P <1 × 10 −5 ). 2 Furthermore, a recent gene-set enrichment analysis of the SZGene database 25 identified 24 pathways significantly enriched for schizophrenia candidate genes among which the serotonin receptor signaling pathway was ranked second. 7 The ubiquitin mediated proteolysis pathway (UPP), a critical system for the removal of damaged/toxic proteins in the cell, has been shown to be dysregulated at the transcript 26 , 27 , 28 , 29 and protein levels 30 in both peripheral and central tissue among individuals with schizophrenia.

Correlation analysis between the co-expression module and traits was carried out, and two highly significant trait-related modules (|cor| > 0.75, p -value < 1 × 10 −5 ) were identified.

For all data sets (cortical CBF, subcortical CBF or RBF; during blood removal or reperfusion), three-parameter logistic regression curves with highly significant correlations for blood flow and MABP could be fitted to the data ( Figure 4 ; correlation coefficients are given in the respective panels; p < 0.00001 for all data sets).

the time from diagnosis (in radically treated patients) until the first appearance of regional recurrences or distant spread, and overall patient survival (survival time until death from thyroid cancer) were compared across seasons. RESULTS Registry cases The 2627 thyroid cancer cases diagnosed in Norway during 1970-85 showed a highly significant time-effect when incidence was compared across 12 months (X2 = 119.3, P<0.00001) or four seasons (x2 = 35.6, P<0.00001), being highest during the last 3- month period October-December (Figure IA).

Supplementary Figure S5 shows quantile–quantile (Q-Q) plots of –log 10 P -values and plots of locations of nominally significant ( P < 10 −5 ) variants across the Drosophila genome.

S3C ), there was a highly significant difference between all groups when clustered by degree of substrate consumption (Kruskal–Wallis p value <0.00001; Fig.

Variants were thus discarded if: (i) UCSC alignability ≠ 1 (100bp window size); (ii) variant within 10 bps of a simple repeat region; (iii) highly significant deviation from Hardy-Weinberg equilibrium (HWE) in cases or controls ( P <10 −5 ); (iv) no call rate significantly different between case-samples and control-samples ( P <10 −5 ); (v) no call rate across either case or control samples >0.03.

Single-marker FBAT analyses display only a non-significant trend in this direction, possibly due to small sample size, but confirm a highly significant divergence in allelic transmission probabilities between autistic patients and unaffected siblings at this locus (P < 1 × 10 -5 , table 5 ).

Similarly, in FA3, the ettringite content showed highly significant increases from 0.03% to 0.24% by aging (Z = 11.24, p < 0.00001).

Three additional islands of highly significant homology ( P < 10 -5 ) were identified further upstream.

When comparing each variable (GI35, GI42 and DTF) between years (Figure 2b–d ), highly significant correlations were observed ( P < 0.00001) supporting a strong genetic control of these traits.

The results were highly significant (R = 0.96, p < 0.00001), indicating that the variations in codon usage are strongly correlated with the nucleotide content (i.e., GC content) of the genes.

Future habitat suitability variation Pearson’s correlation coefficients between the habitat suitability maps generated for the different timeframes (2041-2060 and 2061-2080) and future climate scenarios were all higher than 0.999 for the ALP models and between 0.991 and 0.999 for APE; all the correlations were highly significant after Dutilleul's correction for spatial autocorrelation (p < 1×10 −5 ).

Two QTL with near-significant p -values ≤1 × 10 − 5 were located on Chromosome 2, including a Ser/Thr receptor kinase-like protein and a spectrin repeat-containing CHUP1 homolog involved in chloroplast movement and anchoring to the plasma membrane.