Barely Significant

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extremely significantP -value ≤0.00010.0× alphaqualified
highly significantP -value ≤0.0010.0× alphaqualifiedgold
Statistical significance was defined as non-significant ( ns P -value >0.05), significant (* P -value ≤0.05), very significant (** P -value ≤0.01), highly significant (*** P -value ≤0.001), and extremely significant (**** P -value ≤0.0001).
highly significantp < 0.00010.0× alphaqualifiedgold
The Egger’s test result was highly significant (t = 6.60, p < 0.0001), indicating potential asymmetry and suggesting the likelihood of publication bias ( Supplementary File S26 ). - Similarly, in the OS multivariate analysis, the funnel plot showed some studies lying outside the triangular area, consistent with significant heterogeneity.
highly significantP < 0.00010.0× alphaqualifiedgold
As shown in Figure 3 , rEg.P29 alone did not induce a significant increase in specific IgG at 20 weeks post-immunization, whereas the formulation with Quil A adjuvant elicited a highly significant increase in rEg.P29-specific IgG ( P < 0.0001), confirming that Quil A is essential for inducing a robust IgG-dominant humoral immune response in sheep.
highly significantp < 0.00010.0× alphaqualifiedgold
Simultaneously, the results from Table 2 reveal that the individual factors A and D exert a highly significant influence on the response value ( p < 0.0001), while factors B and C exhibit a significant impact ( p < 0.05).
showed a trendP = 0.00010.0× alpha
The levels of IL-6, NF-κB, iNOS, and NGAL were significantly altered or showed a trend towards being altered by chronic noise and APP/PS1 overexpression (Fig. 5 a–d, ANOVA output: IL-6: exposure F (1,18) = 24.27, P = 0.0001, genotype F (1,18) = 0.5591, P = 0.4643, interaction F (1,18) = 0.005064, P = 0.9441, post hoc WT CON vs WT NOISE P = 0.0080 , WT CON vs APP/PS1 CON P = 0.9629 ,
highly significantp-value <0.00010.0× alphaqualifiedgold
The mean value of TC in the TRM and non-TRM groups using the Mann-Whitney U test registered a highly significant p-value <0.0001 at 18 months, with a decrease of 14.17% from baseline in the TRM group and a decrease of 1.53% from baseline in the non-TRM group.
a decreasing trendp-values < 0.00010.0× alphagold
an increasing trendp-values < 0.00010.0× alphagold
However, there was a change in pattern of incidence for some case types over time with preterm rupture of membrane, preeclampsia, and preterm labour showing a decreasing trend (p-values < 0.0001) and fetal anomaly showing an increasing trend (p-values < 0.0001).