Barely Significant

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highly significantP <0.00010.0× alphaqualifiedgold
The study successfully captured significant longitudinal trends in both humoral and cellular immunity, including a highly significant decline in anti-spike IgG antibodies ( P <0.0001) and group-wise differences in IFN-γ levels ( P =0.0299), indicating the robustness of the cohort size and design.
Authors' response.
Indian J Med Res · 2025 · PMC12550438
highly significantp = 0.00010.0× alphaqualifiedgold
The effects of the study drugs on gut microbiome β-diversity at the OTU level were first tested statistically using a two-way NPMANOVA and the results revealed highly significant main effects for drug (F 4,65 = 3.35; p = 0.0001) and time (F 2,65 = 8.43, p = 0.0001), as well as a significant interaction (F 8,65 = 1.77, p = 0.0001).
highly significantp < 0.00010.0× alphaqualifiedgold
The regression of the distance between F ST and geographic distance in km was highly significant for all population comparisons (males collected in early summer, R 2 = 0.51, p < 0.0001; females collected in early summer, R 2 = 0.60, p < 0.0001; males collected in late summer R 2 = 0.71, p < 0.0001; females collected in late summer R 2 = 0.65, p < 0.0001) (Fig. 2 a-d).
highly significantp < 0.00010.0× alphaqualifiedgold
There was a moderate but highly significant positive correlation between lifetime psychedelic use and nature relatedness at baseline (r = 0.306, p < 0.0001, Figure 1 ), reflected by the mean nature relatedness values ranging from M = 3.52 (SD = 1.03) for psychedelic-naïve participants to M = 4.45 (SD = 0.55) in individuals who indicated more than 100 occasions of psychedelic use.