Excerpts

Among a set of 477 genes showing estrogen-induced expression in MCF7 cells ( Figure 6D , “E2 induced”), 115 showed loss of expression in response to ELF5-V5, an overlap with a highly significant p -value ( p = 5E−84) and odds ratio (OR = 16).

GDF11 and the EGF receptor inhibitor AG1478 regulated a common set of 2466 probes, with a highly significant ( p <10 −83 ) r value of 0.37.

Genome size remained a highly significant predictor of the number of metabolites in the microbial genomes per species ( β = 6.99 × 10 −5 , p = 6.97 × 10 −83 ), indicating that genome completeness does not confound the observed relationship.

The difference was highly significant (p = 8.7E-83, Fisher exact test; OR = 334 [146–864]; Table 2 ) with 79 out of 93 SFTs that were positive (85%) versus only 12 out of 752 STSs (1.6%), thus confirming the transcriptional data.

When comparing IBD genes to non-IBD genes within each tissue group, we observed highly significant differences across all categories: brain tissues ( p = 9.39 × 10 −82 ), GIT tissues ( p = 2.65 × 10 −97 ), and other tissues ( p = 1.17 × 10 −90 ), indicating that IBD-associated genes have distinct expression profiles compared to background genes.

The division of the San and Damara forager groups was in line with ADMIXTURE clustering, with highly significant correlations of admixture fractions between methods (Pearson correlation; R = 0.76 and 1.00, P -value = 1.21 × 10 −81 and 3.59 × 10 −13 ; Supplementary Fig. 5a, b ).

The RM-ANOVA revealed a highly significant main effect of NRR was observed (PCC: F = 381.13, p = 1.65 × 10 −81 ; PLV: F = 568.72, p = 2.37 × 10 −93 ), suggesting a strong influence of NRR values on the results.

Remarkably, we observed a highly significant overlap (hypergeometric test, P = 2.44e-81) between the AS genes in smad1 -cKO (121/512) and smad1 -KD (121/660) PGCs (Fig. 7b ), such as ccdc187 (coiled-coil domain containing 187) that is involved in microtubule anchoring and located in the centrosome 51 , mak ( male germ cell associated kinase ) that encodes a serine/threonine protein kinase related to cell cycle regulation 52 , tinf2 ( TERF1-interacting nuclear factor 2 0) that encodes one subunit of shelterin complex involved in distinguishing between telomeres and DNA damage 53 , among others (Supplementary Fig. 7a ).

SNPs near APOE gave highly significant results (e.g., rs2075650, p = 3.2×10 −81 ), but no other genome-wide significant evidence for association was obtained in the full sample.

Results Monocyte responsiveness to LPS showed a highly significant, negative correlation with blood pressure levels (ρ< -0.4; P<10 -80 ).

Indeed, both tumour types showed highly significant retention of intron 8 sequences in association with rs700635[C] ( P = 8.3 × 10 −80 and 1.4 × 10 −34 for breast and prostate tumours, respectively; Supplementary Material, Fig.

In the whole dataset, eight highly significant recombination breakpoints were identified in the genomes of the four variants cited above ( p -values < 10 −79 , Table 4 ).

Statistical Significance of Circuit Category Effects One-way ANOVA on proof generation times across the seven non-ECDSA circuits reveals highly significant differences ( F = 355.0 , p < 10 − 79 ), with circuit type explaining 94.1% of variance ( η 2 = 0.941 ).

There was a highly significant overlap (p=1.2 × 10 -79 , n=113) between the differentially expressed genes from the two tissue types, indicating that the tissues respond to oncogenic Ras with both common and tissue-specific transcriptional responses.

As shown in Table 1 , the PGF levels are higher in the Denmark sample (median ± interquartile range, sd: 15.9±4.9 in Denmark vs 12.2±4.7 in Cilento) and the difference is highly significant (p = 3.9×10 −79 ) (see Figure 2 ), as assessed with a multivariate analysis taking into account the effect of age, sex, menstruation, and smoking and using the Cilento age-matched sample.

Furthermore, the overlap in hits between cell lines was highly significant ( p < 1e-78, hypergeometric test; Figure 3G ).

This result is highly significant, with P-value<10 −77 ; this p-value is calculated based on 10,000-time permutation evaluating the possibility that 66 out of 83 randomly selected regions overlap or contain with CpG island.

As additional validation supporting the role of myeloid-derived cells, and specifically monocytes, as a dominant contributor to plasma CyC levels, we found a significant positive correlation between blood monocyte counts and CyC residual in the UKB cohort ( Figure S4 B; multivariate regression), and two-sample Mendelian randomization using blood-derived CST3 eQTLs (eQTLGen 58 ) as exposure identified a highly significant positive association with CyC production (p = 6.13e−77; Figure 4 E).

Results for the theta band showed a highly significant association between the mean relevance of each brain region, and how their centrality changes in association with p-tau231 levels (rho = 0.499; p = 9.2 × 10 –77 ).

Similarly, the results revealed a strong positive correlation between RA Factor and disease severity, with Spearman’s ρ = 0.902 and a highly significant P -value < 3.9 × 10 −76 ).

All genome-wide analysis was conducted with only highly significant enhancers [-log10(P) > 75] and NREs [-log10(P) > 30] which intersected strongly accessible chromatin from peaks which overlap MACS peaks called from the input plasmid library alone.

The Pearson correlation of individual question scores for the same participant was r = 0.19, which was highly significant with p = 7e-75 (n = 9520).

We performed reduced representation bisulfite sequencing (RRBS), 5 a technology for interrogating hundreds of thousands of methylation sites with digital precision 27 , 28 on the rat PNS and found characteristic and highly significant patterns relating gene methylation and activity (p≈1.0x10 −74 ) that differed markedly between LCP and HCP genes.

The results clearly show an overall highly significant increase in the number of such events in TA MSI clones compared to TA MSS malignant clones ( p -value < 2 × 10 −74 ).

T2D status was found to be a highly significant predictor of weight loss efficacy ( P = 2.0 × 10 −73 ; Supplementary Table 4 ), with an average predicted reduction of 2.87 percentage points in BMI loss for people with a T2D diagnosis.