Excerpts

Survival analysis for this alteration showed that the difference between wild-type (WT) and NOTCH1 deletion patients was highly significant for both PFS (mPFS: 1.40 vs. 7.83 months; HR = 51.00, 95% CI: 4.80–540.00; P < 0.0001) and OS (mOS: 4.07 vs. 38.30 months; HR = 1 × 10 10 , 95% CI: 0-infinity; P < 0.0001) (Fig. 3G, H ).

The analysis of variance (ANOVA) shown in Table 5 confirms that the developed quadratic model is highly significant for predicting size add-on (%), with a model F -value of 86.77 and a p -value < 0.0001, indicating an excellent fit of the response surface model to the experimental data.

When we focused on the distribution of genotypes containing the mutant alleles (DG+GG and RH+HH), we found highly significant differences between cases and controls ( χ 2 = 16.2, P < 0.0001 for TAP1 -rs1135216 and χ 2 = 4.5, P = 0.03 for PSMB9 -rs17587). 3.3.

Variance analyses (data not shown) confirmed great variability among RILs shown by highly significant values of F tests (F value 3.9, 2.4 and 1.82, p <0.0001 for dry and wet seasons and greenhouse experiments, respectively).

The effect of TYPE was highly significant (χ 2 (3) = 669, p < 0.0001), and the full model was strongly superior to the null (ΔAIC = –657).

The ROC analysis showed an area under the curve (AUC) of 0.78, with a highly significant p -value of < 0.0001, as illustrated in Fig. 2 .

Enrichment analysis of these null variants in heterozygosity against gnomAD-NFE revealed a marginally significant enrichment (OR, 2.39 [95% CI, 1.65–3.47], P <0.0001) that was not validated against internal controls (OR 1.34 95% CI, 0.74–2.42], P =0.337; Table S9 ), reinforcing our approach of treating cases with heterozygous null variants in TRIM63 as negative.

The exposure rate of the study population varied from 23.6% to 28.0%, and there was a significant trend toward increased exposure rate over time ( p < 0.0001).

The interaction between the mutational subgroup and treatment was highly significant (P<0.0001).

At MWU, a highly significant variation ( P < 0 0. 0001) in PDS was observed among the wheat lines and ‘Maddawalabu’ ( Table 2 ).

This level of therapeutic efficacy was highly significant, with a Fisher’s exact test 95% CI range of 79.7–99.9% (p<0.0001).

Across the 2 h testing period there was a highly significant genotype by time bin effect ( F = 5.88; p<0.0001 ; Fig. 3D ).

Differences between the two groups were highly significant (p<0.0001; unpaired T-test with Welch's correction), reflecting the recent and remote diversification histories of acute and chronic sequences, respectively.

Furthermore, the difference between the slopes obtained in the presence and absence of mixed external solutions was also extremely significant ( P < 0.0001).

In these samples, we previously reported a highly significant positive correlation between the 71A1/3D6 oligomer values and both total tau ( r = 0.71, * p < 0.0001; Fig 3A ) and phospho‐tau 181 ( r = 0.70, * p < 0.0001; Pearson correlation coefficients; Fig 3B ) and no significant correlation with Aβ1‐42 monomer levels (Fig 3C ). 21 A separate cohort of control CSFs from 40 young (mid‐30s), healthy control individuals was also assayed, and their CSF 71A1 oAβ levels were compared with the patients from the BWH MAC cohort after further stratification.

The meta-regression of the year over logit-transformed prevalence showed a trend towards an increasing prevalence of beta-blocker use from 1995 to 2015 with a slope of 0.1 (p<0.0001).

Paired Wilcoxon rank sum tests revealed highly significant differences ( P < 0.0001 for BLAST and k-mer matching) in accuracy favoring the rRNA operon.

Among the 200 primary gastric carcinomas of the referred dataset, a statistically highly significant positive association (Spearman’s rank correlation p < 0.0001) between the expression of ERBB2 and FUT3 genes was observed ( Figure 5 d).

Differences were considered significant when p<0.01 (*), and highly significant when p<0.0001 (***).

We observed a highly significant nonlinear association of urinary 8-oxoGuo with serum ferritin ( P < 0.0001) and higher 8-oxoGuo concentrations for respirable iron >1,000 μg/m 3 compared to ≤57 μg/m 3 .

There were highly significant ( p < 0.0001) associations between the abnormal expression of E-cadherin and Vimentin, E-cadherin and β-catenin, Vimentin and β-catenin, SMAD4 and E-cadherin, and a significant association between SMAD4 and Vimentin ( p = 0.0003), and SMAD4 and β-catenin ( p = 0.001) as shown in Table 1 .

Additionally, 16 cases and 2 controls had protein S (PS) values of less than 48.4% (M-2SD), exhibiting a highly significant difference ( P < 1 × 10 −4 ).

A significant trend toward a decrease in the number of skin lesions was observed (p<0.0001).

The difference between the curcumin-pretreated and -untreated rats suffering from TBI was extremely significant ( p < 0.0001 compared to control group; Fig. 2C ).

This difference was highly significant ( P < 0.0001).