Excerpts

Indeed, the fnr − mutant showed an 8-fold reduction in expression of type I fimbriae and a highly significant ( P < 0.0001) reduction in expression of fimA, ompT (plasmid-borne), and aatA .

Following the diet period, quantitative real-time polymerase chain reaction revealed a highly significant increase of P2X 4 expression in aortic arches with atherosclerotic lesions ( p < 0.0001, Fig. 1 A), compared to non-atherosclerotic aortic tissue.

Interestingly, all wounds that were scored as hypergranulating from the macroscopic evaluation also showed a positive volume when measured by the 3D scanning, and a significant trend ( p = 0.0001) towards higher hypergranulation scores with increasing volume was demonstrated using Jonckheere’s trend test ( Figure 2 K).

A statistical significant effect was found for each covariate and the joint test for all covariates was highly significant (p<0.0001).

reported a highly significant difference in ocrelizumab groups (P<0.0001) for a total number of gadolinium-enhancing T1 lesions at weeks 12, 16, 20, and 24 versus placebo [ 19 ].

As shown in Table 3 , it was apparent that the model was extremely significant (p < 0.0001) for quantification of extraction yields of GLA (Y 1 ) and ISL (Y 2 ).

Using a more sophisticated haplotype-based method (focusing on ∼21% of the genome), we found 24 highly significant ( P < 0.0001) haplotype blocks suggestive of selective sweeps.

We used the adonis2 function in the qiime2 plugin (q2-diversity) to perform permutational multivariate analysis of variance (PERMANOVA) with 999 permutations, and the included interaction terms (see Table S3 in the supplemental material) and separation of the groups were highly significant ( P = 0.0001).

This difference was statistically highly significant ( P < 0001) [ Table 1 ].

The intracohort differences in the malodor scores compared to baseline were highly significant in both cohorts, with p values < 0.0001.

With the HEMI groups, although LIB appeared to induce a slight decrease in reversal learning during both dark phases, these differences did not reach statistical significance upon comparing between the HEMI Sham and Blast groups [Time: F (4.687, 103.2) = 39.35, p < 0.0001; Group: F (1, 30) = 0.2318, p = 0.6337; Time × Group: F (46, 1,380) = 0.4483, p = 0.9995; Subject: F (30,1,380) = 26.52, p < 0.0001]. 3.2 Cognitive flexibility of the reversal learning The main purpose of the reversal learning phase is to evaluate cognitive learning flexibility of the HEMI and NCAR mice.

Results : When comparing the mean scores before and 2 years after the surgery, a highly significant improvement was found for QoSL and dysmenorrhea ( p < 0.0001).

Although this difference is highly significant (p<0.0001, t = 4.6345, df = 1355, SE = 0.058), the degree of the difference in linear dimensions is relatively small ( Fig 18 ).

Our univariate logistic regression analysis shows a highly significant relationship between CT-FFR ML and stress perfusion CMR, with Chi 2 = 47 ( p < 0.0001).

In the ‘immediately after surgery’ subgroup, the SMD with a 95% CI is −0.76 [−1.10, −0.42], with a highly significant p -value < 0.0001, I 2 = 9%.

The differences across these groups were highly significant ( p < 0.0001), indicating a positive correlation between MIF levels and disease severity.

SUV max and TBR GGO/consolidation There were highly significant group-wise differences ( p < 0.0001) across both the COVID-19 and BSTI classifications.

This ratio at baseline was highly significant ( p < 0.0001) and was excellent to discriminate between responders (and prolonged PFS) and nonresponders (AUC = 1.0).

described that the ACQ score significantly decreased from 3.58 ± 1.28 to 2.01 ± 1.05 after 16 weeks (−43.7%), treatment responders showed greater and highly significant improvements of symptoms compared with non-responders even after 16 weeks (−46.9%, p < 0.0001 vs −36.1%, p < 0.05) [ 16 ].

Genotypic effects were highly significant in nearly all environments ( p < 0.0001); the sole exception was 23_WL, where IR was non-significant ( p = 0.0876) and both traits showed low heritability (IR: H 2 = 0.19, h 2 = 0.03; SV: H 2 = 0.27, h 2 = 0.05) (Table 1 ), consistent with uneven disease pressure.

Significance was indicated as follows: not significant (ns): P ≥ 0.05; significant: * P = 0.01 to 0.05; very significant: ** P = 0.001 to 0.01; extremely significant: *** P = 0.0001 to 0.001; and extremely significant: **** P < 0.0001.

This difference was highly significant (p < 10 −4 , Kolmogorov–Smirnov test).

The model showed that X 2 , X 3 , X 1 2 and X 2 2 had a significant effect on the tyrosinase-inhibiting activity ( p < 0.05) and that X 3 2 had an extremely significant effect on the same ( p < 0.0001).

Using the same statistical procedure described for Figure 2 , this overlap between the experimental data and the theoretical prediction is highly significant ( P < 0.0001).

Quantitative analysis confirmed this observation, demonstrating a highly significant increase in the number of CD68 + cells in the bone marrow of LP-18 M animals ( p < 0.0001) (Fig. 8 ).