This effect is strongest for the pairwise deviation between means (61% reduction), but also highly significant for the other measures ( P < 10 −20 in all cases).
Excerpts
Fourth, there is a highly significant enrichment for extreme iHS values in genic regions ( p < 10 −20 in all populations; Table S1 ).
Nevertheless, the above fraction of 77% validated genes is highly significant with a Binomial tail p-value < 10 -20 .
Each of the three possible pairwise regressions were highly significant with p<10 −20 .
The overlaps between the studies were highly significant in most cell types ( P < 10 −20 , hypergeometric test) with the exception of the case of chimpanzee OPCs, because no genes were shared in this case ( SI Appendix , Fig.
The overlap of Arc-dVenus -enriched genes with activity-regulated and visual stimulus-induced genes is highly significant (each p < 10 −20 , hypergeometric test) ( Fig. 3C,D ).
Two highly significant loci mapped to chromosome 17 and chromosome 4 After the Hardy-Weinberg equilibrium test (Fisher’s exact test, P -value > 10 −20 ), 15,092,493 biallelic SNPs on all 29 autosomes remained for the GWAS.
While the prediction of these algorithms was far from being perfect for each individual RNAi trigger, we found a highly significant correlation (Pearson = 90.6%, p < 10 −20 ) between this algorithm’s scores and our average screen score.
It exhibited highly significant associations with multiple musculoskeletal traits, most notably with appendicular lean mass ( p = 1.0 × 10 −20 ), trunk fat-free mass ( p = 1.8 × 10 −8 ), and standing height ( p = 2.0 × 10 −9 ).
A highly significant association peak (–log 10 ( P ) = 19.89) was identified on chromosome 1, exceeding the significance threshold (interval: 36,313,286–36,586,879 bp, spanning approximately 273.6 kb).
The intraclass correlation coefficient (ICC) for the accuracy rate was 0.982, indicating near-perfect agreement between raters, with a highly significant F test ( P = 1.36 × 10 −20 ).
The relationship between the time point and membership of the clusters was highly significant (chi 2 P = 1.4 −20 ).
ANOVA results revealed a highly significant overall effect ( F = 35.3, p = 1.7 × 10 ‐20 ), providing strong evidence of differences between the subject groups.
The TyG index demonstrated a highly significant progressive increase (ANOVA p = 1.74 × 10 −20 ; Kruskal–Wallis p = 7.77 × 10 −21 ), rising from approximately 8.3 in the lowest risk categories (scores 2–3) to about 10.0 in the highest risk group (score 10).
A moderate negative ( r = –0.27), but statistically highly significant ( p = 1.75E-20) correlation was observed between bisecting GlcNAc (FB n /F n total) and core fucosylation of IgG (F n total), which confirmed the results from in vitro studies.
Depression was a highly significant ( P = 1.8 × 10 −20 ) risk factor for AF recurrence after CA (RR: 2.3, 95% CI: 1.75–2.9), supported by suggestive evidence. 39 The mechanism of this association is unclear; however, it has been suggested that depression may be associated with chronic inflammation and can increase sympathetic activit
The distribution of resistance profiles across the years demonstrated a highly significant change (Chi-square = 137.36, p ≈ 2.06 × 10 −20 ), strongly suggesting that resistance patterns have not remained static over time.
A highly significant age correlation was also obtained for the ELOVL2 gene (N = 58) (R = 0.887, p = 2.099 × 10-20).
There were highly significant differences in regional grey matter volumes, particularly of mid- and hindbrain structures, such as cerebellum (beta = −9.91E-04, T = −9.26, P = 2.25E-20), pons (beta = −5.63E-04, T = −6.23, P = 4.95E-10) and midbrain (beta = −4.00E-04, T = −5.15, P = 2.67E-07) in gout and high urate (Fig. 2 ).
We find a highly significant sharing (P = 2.28e-20) of segment and interaction domain endpoints, with 60.8% (571/939) of interaction domain endpoints also being segment endpoints.
The second locus showing a highly significant association with the erythrocyte Cu levels ( P = 2.6 × 10 −20 ) contains the gene selenium binding protein P (SELENBP1).
Highly significant differences were observed between the means of three variables—the Toronto sample had more PsA patients (93.0% vs. 58.3%, p = 2.9 × 10 −20 ), while the Michigan sample had a higher mean age (51.4 yrs vs. 46.0 yrs, p = 8.6 × 10 −7 ) and a higher percentage of patients with a family history of psoriasis (60.6% vs. 42.9 %, p = 4.5 × 10 −5 ).
Statistical analysis using two-proportion z -tests on both median and maximum values (representing the most conservative estimate) confirmed that from training Day T3 onward, the reduction in “h–c–b” transitions was highly significant compared with baseline (median, T3 p = 3.24 × 10 −20 ; T4 p = 1.73 × 10 −12 ; maximum, T3 p = 3.17 × 10 −18 ; T4 p = 1.73 × 10 −12 ).
In fact, we found a highly significant correlation ( R = 0.2 and P = 5 × 10 −20 ) between RNA accessibility and ribosome density around the translation start sites ( Fig. 4A ), and the peak correlation locates approximately 10 bases upstream of the translation start site, the 5′ position of the occupancy site of the first ribosome in yeast ( Ingolia et al. 2009 ).
There was a notable trend toward lengthening of the 3’UTR in cancer cells ( P = 5.59 × 10 −20 ), with COL1A2 emerging once more as the most prominent finding ( P corr =7.48 × 10 −47 , 61% change) (Figs. 3b, c and 4f ).