The rs334 SNP, when directly genotyped, was highly significant ( P = 1.3 × 10 −28 ), whilst the best marker in the GWAS SNPs ( P = 3.9 × 10 −7 ) did not reach genome-wide significance.
Excerpts
Comparison of Models 1 ( α = β 1 = β 2 = 0) and 2 ( α = 0) in Table 2 reveals a highly significant offspring SE allelic effect on RA risk ( χ 2 2 = 128.1, p = 1.5 × 10 -28 ).
The scores only explained 3% of the variance in schizophrenia case-control status, but the large sample sizes ensured that this was highly significant (up to P = 2 × 10 −28 ).
Instead, we observe that an increase in STAT3 binding is correlated with an increase in expression in most of these pairs (83%, n = 686), an association that is highly significant at P = 2.3 × 10 −28 ( Table 4 ).
The type of incubation fluid exhibits a highly significant impact on the sorption ability, as indicated by an exceptionally low p -value ( p = 2.45 × 10 −28 ), suggesting that the fluid type strongly influences the swelling behavior of hydrogels.
However, although the difference in terms of percent variation explained in RBC by SSCCA vs SSMCCA methylomics CV1 is highly significant (p-value = 3E-28), the absolute difference (4.27E-8 percent variance explained) is tiny, suggesting the difference between the performance of two methods is negligible.
As shown in Table 2 , the DEGs from the Rat in vitro model (Rat-DEGs) exhibited a high correlation with those from the Human in vitro model (Human-DEGs), sharing a highly significant gene overlap ( P = 4.02E-28).
rs13038305 in Relation to Cystatin C At baseline each copy of the major allele of rs13038305 was associated with a highly significant approximately 0.30 standard deviation (SD) higher plasma concentration of cystatin C both in model 1 (β = 0.33, p = 4.2E-28) and model 2 (β = 0.33, p = 1.7E-29).
Although the MHC association is highly significant in both OLP and non-OLP, it is dramatically stronger in non-OLP ( p = 5.6 × 10 −28 for difference in effect), and the association in non-OLP near CLEC16A does not even reach nominal significance in OLP.
Expectedly, a highly significant naming deficit became obvious for LIP in comparison to HIP (p=7.0×10 -28 ) and healthy controls (p=9.1×10 -29 ) (Figure 2 C).
In the offspring cohort, the spouse correlations were lower but still highly significant for PC1 (r = 0.38, P = 7x10 -28 ) and for PC2 (r = 0.45, P = 2x10 -39 ).
In general a highly significant correlation between miR-122 expression levels and target gene perturbation was observed in HCC samples ( p = 8.1 × 10 −28 ).
The results with GENECONV (Table 1 ) were highly significant (p values < 10 -27 -10 -66 ) between the paralogues of the same species in groups 1, 2 and 3 providing evidence of gene conversion between ancestral sequences of paralogues.
This 14-fold increase of gene numbers regulated by HPV E7 in addition to E6 among pocket protein target genes is highly significant ( P < 10 −27 ) and thus substantiates the model that p53 can directly activate its target genes while p53-dependent repression largely occurs via the p53-p21-DREAM/RB pathway.
The overlap between our gene list and previously published data [ 29 ] was highly significant (35% overlap, hyper-geometric test p < 10 −27 ), and dissimilarities were likely due to the different ages of flies in the two studies (40 days in the current study as opposed to 10 days in [ 29 ]) as previously reported [ 30 ].
Inception-v4 consistently ranked last, with an accuracy of 87.42% and an AUC of 94.24%, and exhibited highly significant disadvantages compared with all other models ( p < 10 − 27).
The top five ranked interlinked pathways (Supporting Information Table S5 ) and the three Gene ontology (GO) molecular function terms (Supporting Information Table S6 ) are highly significant ( p ≤10 −27 ) with respect to genes differentially expressed after RPL19 knockdown.
However, only the primary angiosarcoma specimen, AS1, exhibited a prominent and highly significant ( P <10 −27 ) expression transition ( Figure 2A ), with the predicted breakpoint corresponding to known rearrangements of ROS1 in other malignancies.
Differences between the two groups were highly significant (p = 1.5×10 −27 ).
The discrimination capacity of the model was high (AUC = 0.811) and highly significant ( p = 1.782 × 10 –27 ).
The results of this analysis, following removal of outliers, revealed a highly significant effect of the mutation type (specifically splice-site mutations) on the number of CALs, both with 1 to 5 CALs ( p = 1.8 × 10 −27 ) and 6 to 99 CALs ( p = 8.5 × 10 −43 ), as well as for skin freckling ( p = 0.028) and neoplasms ( p = 0.006).
Association analysis revealed a highly significant association between rs13292899 and NSCL/P risk ( p = 1.85 × 10 −27 ) [ 73 ].
These analyses also further revealed highly significant associations for the MRPS18C isoform uc003hor ( P = 1.94x10 -27 and r 2 = 0.143) (Figure 6E ).
In addition, we identified highly significant missense variants (<5 × 10 −15 ) within the FLG gene (rs558269137, beta = −0.222, p = 1.96 × 10 −27 ) and the KRT1 gene (rs14024, beta = −0.030, p = 3.95 × 10 −15 ).
The samples clustered into two distinct and well-separated classes, and evaluation of the model showed that it was highly significant ( p = 2.3E −27 permutations p = <0.001).