Excerpts

Two-way ANOVA revealed a highly significant difference between the two cell lines ( p = 4.68 × 10−27), indicating a strong overall effect of cell type on the outcome (partial η2 = 0.484).

Gene ontology term analysis for the training response also revealed a highly significant over-representation of neurological processes ( Neurological system process: P = 4 .85 × 10 −27 , Cognition: P = 1.92 × 10 −22 , Sensory perception: P = 4.21 × 10 −21 ) and the extracellular region ( Extracellular region: P = 1.40 × 10 −10 ).

This difference was highly significant by both parametric (Welch’s t = 11.40, p = 4.98 × 10 −27 ) and non-parametric (Mann-Whitney p = 3.59 × 10 −19 ) tests, with a large effect size (Cohen’s d = 1.14).

The average difference in TraP scores between the groups is highly significant (0.62 vs. 0.078, pathogenic versus benign variants, respectively, MW-test, P -value = 7.1 × 10 −27 ).

Remarkably, there was a highly significant overlap ( P = 7.29E–27) between genes affected at gene expression and splicing level (391, 42.6%; Figure 2C ).

Interestingly, we found a highly significant dependency of FCER1A expression on GATA-2 transcript levels (p = 7.8×10 −27 ).

The model achieved a highly significant separation of the overall survival ( p < 10 −26 , c = 0.65 ± 0.02, Fig. 2 b), with distinct survival trajectories across the three clusters.

A similar analysis performed between populations from Libreville and either of the village and sylvatic LLP areas shows highly significant differences ( p ‐value < 10 −26 for each test; Figure S7 ).

Figure 5 D illustrates the large degree of overlap between wild-type LD and wild-type DD oscillators, a highly significant (Fisher's exact test p < 10 −26 ) and unsurprising result, considering the extensive program of circadian expression that is detected in combined wild-type LD + DD data ( Figures 2 A, 2 C, 3 A, and 5A).

S3A), but the overall altered profile was highly significant ( P = 10 −26 , Fisher exact test in comparison with the ∼8,000 genes expressed).

The ANOVA results confirmed that the observed differences in Ct values for COX-IV i1 and COX-IV i2 were highly significant (F(2,83.71) = 132.95, p = 1.04 × 10−26 for COX-IV i1 ; F(2,84.89) = 280.32, p = 4.02 × 10−38 for COX-IV i2 ) (Fig. 3 & Supplementary Fig.

The test revealed a highly significant discrepancy between Google Gemini and the registrar (p = 1.13 × 10 -26 ).

When looking at the subsets created independently for each method, we see a highly significant overlap, with 190 of 231 CHEQ-seq positives being labeled as positives or grayzone in STARR-seq (82.3%, χ 2 P -value = 1.24 × 10 −26 ) ( Fig. 2 B,C).

Indeed, 26% (133 out of 508) of differentially expressed proteins from Cd2ap +/− heterozygotes were also seen in Cd2ap −/− homozygotes, comprising a highly significant overlap ( P = 1.6 × 10 −26 ) ( Fig. 7A ).

Furthermore, X-11244 displays a highly significant genetic association (p = 2.1×10 −26 ) with rs296391, which lies in strong LD in the SULT2A1 gene locus.

Interestingly, after correcting for the effect of potential confounding variables (see Materials and Methods ), we found small but highly significant positive correlations between micronucleus level and several hematological measures; the red blood cells distribution width (RDW, P = 2.55 × 10 −26 , Spearman R 2 = 0.1), the hemoglobin concentration distribution width (HDW, P = 1.63 × 10 −12 , R 2 = 0.04, Spearman), the mean cellular hemoglobin concentration (CHCM, P = 3.14 × 10 −11 , R 2 = 0.04, Spearman), and the measure of blood hemoglobin (measHGB, P = 1.88 × 10 −6 , R 2 = 0.02, Spearman).

This codon is the eighth most frequently mutated codon in CRC and this mutation is extremely significant in our stool sample (P = 2.72e-26, P Bonf = 9.35e-24).

A highly significant SNP, S3_45847468 (P-value = 2.99 × 10−26), was detected for PRL using the 3VmrMLM model at the V 1 stage.

By contrast, there was a highly significant main effect of dose (p = 3.5 x 10 −26 ), significant genotype*dose interactions (p = 0.007) and significant dose*session interactions (p = 2.0 x 10− 13 ).

There was a highly significant genetic correlation ( r g ) of FLI with MRI-PDFF within the UKBB ( r g = 0.5345, P = 4.29E−26), whereas full correlation was observed for the same FLI trait between UKBB and UGLI ( r g = 1.0488, P = 8.91E−11), indicating that the estimates (SNP effect size) from the two GWASs are not biased from heterogeneity in ethnicity or environmental exposure in the two cohorts ( Figure 4 ) [ 28 ].

The analysis yielded highly significant results (F-statistic = 119.75, p -value = 4.68 × 10 −26 ), indicating that models do not perform identically and observed differences are unlikely due to chance.

Resting-state functional connectivity Group comparisons of interhemispheric motor cortex BOLD signal r -coefficients, including all ROI pairs, resulted in highly significant K–S differences ( D ) between ALS and healthy participants ( D = 0.19, p < 7 × 10 −26 ) with ALS being less connected overall than healthy controls (see Figures 3 and 4 ).

However, the same eight features resulted in highly significant increases in the proportion of previously known interactions ( Fig 5B ; all P ≤ 7.0 × 10 −26 , Fisher’s method, except P > 0.99 for gene fusion).

The correlation between “correlation coefficients of gene expression levels with reexperiencing symptoms in patients” and “fold change (FC) after retrieval in mice” for the 413 genes was highly significant ( r = 0.49, p = 7.3E-26) (Fig. 3D ).

Furthermore, although enrichment of RNAs with mitochondrial functions among the Leotiomyceta Puf3 targets was highly significant ( Fig 4B , odds-ratio = 3.9, p = 10 −25 by Fisher's exact test), and the overlap with Saccharomycotina Puf3 targets was also significant (13%, odds-ratio = 3.2, p = 10 −6 by Fisher's exact test), the Leotiomyceta Puf3 target set included only 26 of the 202 Saccharomycotina Puf3 targets that have orthologs in N . crassa and included 87 mitochondrial targets not observed in Saccharomycotina.