Barely Significant

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highly significantp < .00010.0× alphaqualifiedgold
There were highly significant positive correlations between DW and all genetic variation measures ( r = .729413, p < .0001, t = 6.3977), meaning that a high number of rare markers (high DW) were associated with high genetic variation.
highly significantp < 0.00010.0× alphaqualifiedgold
A total of 220 patients completed this 24-week study, and highly significant differences in the total number of gadolinium-enhanced T1 lesions were observed in both ocrelizumab groups ( p < 0.0001) at weeks 12, 16, 20 and 24 when compared with the placebo group.
Ocrelizumab: a new milestone in multiple sclerosis therapy.
Ther Adv Neurol Disord · 2018 · PMC5952271
highly significantp < 0.00010.0× alphaqualifiedgold
Expression profiling revealed that SLC7A5 was significantly differentially expressed across cell types, particularly between epithelial cells and fibroblasts, mast cells, plasma cells, and T cells, with highly significant differences (p < 0.0001), suggesting cell type–specific functional roles ( Figure 6G ). 3.7 Mechanistic insights into the role of SLC7A5 in BRCA Gene set enrichment analysis (GSEA) revealed that low-SLC7A5–expressing samples exhibited downregulation of pathways related to immune responses, cell adhesion, and proliferation, including allograft rejection, cell adhesion molecules, cell cycle, and cytokine–cytokine receptor interaction ( Figures 7A, C ).
highly significantP-value < 0.00010.0× alphaqualifiedgold
While the reduced number of genes often leads to a loss of significance within each sex, the general results hold whether or not we consider the ancestral level of expression: (i) a highly significant (***P-value < 0.0001) male-biased expression of the Z, with (F:M)Z/(F:M)A ratio from 0.52 to 0.77, is always observed.