Highly significant and complete protection ( P < 0.0001) was observed in the experimental groups where 4′-FlU treatments were initiated on or before day 4 p.i.
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In contrast, 135992 and 135993 showed highly significant differences between B-ALL and AML co-cultures (p < 0.0001 for both).
Additionally, we noted the levels of hematocrit (HCT) increased significantly over time after infection with a mean count of 31.6, 35.3 (p = 0.0001) and 37.7 (p<0.0001) % at 1, 2, and 3 d.p.i., respectively, when compared to 29.2% in uninfected mice ( Fig 3K ).Thrombocyte (PLT) counts showed a decreasing trend, albeit insignificant, at the early phase of infection, that gradually rebound to thrombocytosis at the peak of infection with a mean count of 952 K/uL (p<0.0001) at day 3 p.i., when compared to those measured before infection with a mean count of 484 K/uL ( Fig 3E ).
This difference was highly significant for the screen detected cancers (P <0.0001).
The model also showed significant correlations with clinical markers, including faecal calprotectin ( r s = 0.50), C-reactive protein (CRP; r s = 0.45) and Physician Global Assessment ( r s = 0.45), all of which were highly significant ( p < 0.0001), supporting the clinical validity of UC-SCALE. 23 Aside of CNNs, other computational methods have been employed to detect mucosal inflammation.
Using GREAT, we found that about 77% of the genes associated with active TFAP2A peaks are also associated with active MITF peaks, a highly significant overlap (hypergeometric test, p<0.0001) ( Fig 3D ).
In contrast, the coefficient of skewness (γ skew ) is negative and highly significant (−0.0021, t = −4.0245, p = 0.0001).
Except for the AD vaccine group, the serum from all the recombinant ADDomer-VLP vaccine groups exhibited extremely significant differences ( P <0.0001) in ND50 on day 35 compared to day 0.
The small subgroup of current smokers ( n = 4) showed a somehow peculiar profile, with highly significant changes in the expression of ICAM1 and NFKB1 ( p < 0.0001 and p = 0.002 respectively) and some other minor variations.
The ANOVA showed a highly significant difference with respect to mean fracture resistance between the three groups ( P < 0.0001) ( Table 2 and Graph 2 ).
All variables but sex ( p = 0.814), upper quadrant periodontal assessment ( p = 0.513), and lower quadrant periodontal assessment ( p = 0.285) showed highly significant differences between the high-risk and low-risk clusters ( p < 0.0001).
+ 0.0817 X 2 X 4 + 0.0405 X 2 X 5 - 0.0402 X 2 X 6 - 0.2873 X 3 X 4 - 0.1011 X 3 X 5 - 0.1967 X 3 X 6 - 0.0283 X 4 X 5 + 0.2186 X 4 X 6 - 0.0289 X 5 X 6 - 0.769 X 1 2 - 0.2811 X 2 2 - 1.64 X 3 2 - 1.13 X 4 2 - 0.2342 X 5 2 - 0.0627 X 6 2 # The ANOVA results ( Table 2 ) indicated that the model was highly significant ( F = 16.76, P < 0.0001) with a non-significant lack of fit ( P = 0.2443), confirming model adequacy.
Here the application of CRMP-5 led to a highly significant increase in the amount of RGCs (p<0.0001).
Cook [ 48 ] summarized the results of an additional 11 family-based studies in a meta analysis and concluded that the association between the DAT gene and ADHD was highly significant (p < .0001).
Furthermore, implementation clinics had a underlying higher probability of identifying patients exposed to violence (0.46); the size of the clinic, proxied by patient inflow was highly significant (p = 0.0001), with larger clinics identifying more patients and, as expected; time (measured in months or calendar months) increasing identification, meaning the underlying trend regardless of the implementation has a positive slope.
S1 , Supplementary Material online), differences with PALO being highly significant for Mammalia, Vertebrata, and paralogs (Mann–Whitney test P < 10 −4 ).
The variance of the random effect was highly significant in all these models (p<0.0001).
At 24 hours, we observed a highly significant decrease in KRAS expression in those groups treated with KRAS-siRNA NP versus control cells or scramble (SC) siRNA NP treated cells (both p < 0.0001 ), with a reduction in KRAS RNA expression from 55–70% ( Figure 2A ).
A full factorial ANOVA revealed that all four factors were highly significant in their impact on children's understanding of complex sentences ( p ≤ 0.0001).
In each subject large off–axis placement of the laser beam caused a highly significant (p < 0.0001) RNFL thickness measurement artifacts in almost all sectors.
The observed effect of trans-4-tert-butylcyclohexanol was highly significant ( p < 0.0001).
A multivariate analysis adjusted for etiology, site, age, and weight in comparison with ideal weight showed that in both young children and in the older population, time spent with plasma FVIII <1 IU/dL was a highly significant predictor of the rate of all bleeding ( P <0.0001 for young children; P <0.05 for older patients) and the rate of joint bleeds ( P <0.0001 for young children; P <0.02 for older patients).
The LMM (R2= 0.4) reveals a highly significant influence of the fixed effect accommodation demand (F(4, 97.01) = 9,3966, p < 0.0001) while the fixed effect session (F(1, 97.67) = 0.1247, p = 0.7248) and the resulting interaction effect (F(4, 97.26) = 0.148, p = 0.9635) between accommodation demand and session showed no significant influence.
AUSTRAL medium) had a highly significant effect on the variability of SBF indexes (Wald = 83.73, **** P < 0.0001) (Table 2 ).
However, the mixture of 10 n m CM4620 and 1 m m galactose provided highly significant protection against BA-elicited necrotic cell death ( P < .0001) as compared to cell death levels in the presence of 10 n m CM4620 alone ( Figure 3A ).