Excerpts

Hypercapnia induced a highly significant increase in POBF values in NTG with a mean increase of 30.4% ( P = 0.0001) but little change was noted in controls whose mean change was 1.1% ( P = 0.7).

Similarly, there were also highly significant differences among the various time points (F = 109.57, P < 0.0001).

The interaction of the two factors was extremely significant ( p < .0001) in reducing tumor size ( Figure 4(A) ).

Statistically significant results were found to have a P value < 0.01 is statistically significant, a P value < 0.001 highly significant, a P value < 0.0001 strongly significant 105 .

A highly significant ( p < 0.0001) decrease from t0 to t1 was observed in: oxidized glutathione (−56% vs. −79%, Figure 2 A); oxidized Cys (−34% vs. −24%, Figure 2 B) and oxidized CysGly (−44% vs. −47%, Figure 2 C) for group GluReS compared to group GluS, respectively.

Combination of adipocytes and growth factors Cultures in minimal medium again showed a gradual decrease in CD34 + cell survival, however the addition of growth factors induced a highly significant ( p <0.0001) increase in the CD34 + cell proliferation, reaching a maximum at 2 weeks ( Fig. 3 ).

Mean FID in the 714 populations ranged from 1 to 180 m, mean (SE) = 11.46 m (1.03; back-transformed from log 10 -transformed data), with a highly significant effect of species ( F = 3.06, df = 158, 555, R 2 = 0.47, P <0.0001).

Figures 1 and 2 illustrate the tumor budding categories. Tumor budding and advanced tumor stage, tumor invasion, vascular invasion, perineural invasion, and desmoplasia were significantly associated. The link between regional lymph node metastases and tumor budding was highly significant (P=0001).

Using the same statistical procedure described for Figure 2 , this overlap between the experimental data and the theoretical prediction is highly significant ( P < 0.0001).

These results are further corroborated by a meta-analysis carried out by the Cholesterol Treatment Trialist’s Collaboration, in which more versus less intensive statin therapy was associated with a highly significant 15% (95% CI = 11 to 18; P <0.0001) further reduction in major vascular events [ 6 ].

The difference was highly significant ( P < 0.0001).

The correlation coefficient between LCT*P frequencies and latitude was highly significant ( r = 0.274, p <0.0001).

There was a trend for a relationship between advancing age and reductions in HOMA-IR (R 2 = 0.06; P = 0.09) ( Figure 5F ), with a highly significant correlation between HOMA-IR before RE-T and RE-T–induced reductions in HOMA-IR (R 2 = 0.34; P < 0.0001), irrespective of age.

Multiple regression analysis using these same co-variants was highly significant ( p < 0.0001; R 2 = 72.7%) with the main variants being nadir SCr >0.6 mg/dL [ p < 0.001; β coefficient: 1.38 (95% CI: 0.9 to 1.9)] and growth (current sds) [ p = 0.03; β coefficient: −0.13 (95% CI: −0.2 to −0.1)].

Two-way ANOVA revealed a highly significant main effect of diabetic status on muscle volume (F(1,34) = 119.04, p < 0.0001), with diabetes accounting for 74.08% of the total variance.

Results A highly significant association (p < 0.0001) was observed for joint space narrowing (JSN) as well as for osteophyte formation between the three groups.

Regarding schistosomiasis, cysteine peptidases, such as papain, Schistosoma mansoni cathepsin B1 (SmCB1) and cathepsin L3 (SmCL3) and Fasciola hepatica cathepsin L1 (FhCL1) do not induce allergic reactions in mice or hamsters and were shown instead to elicit reproducible and highly significant ( P < 0.0001) reduction of 50–65% in challenge S. mansoni and Schistosoma haematobium infection, via generation of polarized (papain, SmCL3, FhCL)- or predominant (SmCB1) type 2 responses involving release of TSLP, IL-4, IL-5, IL-13 and generation of IgG1 antibodies [24] , [25] , [26] , [27] , [28] .

Chi square analysis of the distribution of annexin V FITC and propidium iodide positive cells indicated a positive trend toward apoptosis in dieldrin-treated N27 cells (χ 2 = 69.12, p < 0.0001).

The study group ( Table 2 ) showed a highly significant postoperative increase in both CRP ( p < 0.0001) and IL-6 ( p = 0.0092) concentrations.

A highly significant positive trend in hatchability was observed for the brown layer line ( P = 0.0001), with hatching rates increasing from 52% at ED4 to 87% at ED7.

The difference in survival between the two groups was highly significant (HR: 7.8, 95% CI: 4.0–15.2; p<0.0001) ( Fig. 2 ).

These values were all highly significant (p < 0.0001).

This difference was highly significant in a multivariate linear regression model, p < 0.0001.

A block averaging t -test confirmed this difference to be highly significant ( P -value <.0001, t-statistic = 12.36; Fig. 8 ).

Highly significant differences were observed for deprivation scores ( p < 0.0001) and comorbidity ( p = 0.0007) between the ethnic minority groups with almost half of black Caribbean, Pakistani and black African women in the most deprived quintile, compared to less than a fifth of Indian and white women.