Barely Significant

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highly significantP = 0.00010.0× alphaqualifiedgold
We used the adonis2 function in the qiime2 plugin (q2-diversity) to perform permutational multivariate analysis of variance (PERMANOVA) with 999 permutations, and the included interaction terms (see Table S3 in the supplemental material) and separation of the groups were highly significant ( P = 0.0001).
highly significantp < 0.00010.0× alphaqualifiedgold
Similarly, the percentage of positive fields for IL-13Rα2 expression in 2+ and 3+ positive specimens in IHC analysis demonstrated a highly significant trend in these specimens (well differentiated = 35.0%, moderately differentiated = 82.0% and poorly differentiated = 94%; exact p < 0.0001) compared to PDAC samples with negative values of IL-13Rα2 (≤ 1+) ( Figure 1 D).
highly significantP < 0.00010.0× alphaqualifiedgold
The biophysical factors, including land preparation and cropping system, showed highly significant (P < 0.0001) associations with ascochyta blight intensity in the logistic model as a single variable, and they also maintained their associations with both incidence and severity when included into the reduced variable model ( Table 3 ).
highly significantp < 0.00010.0× alphaqualifiedgold
Statistical modelling of FICI values The results of the Wald χ 2 tests from the fitted linear mixed-effects model evaluating FICI values indicated that antibacterial combination had a strong and highly significant main effect on FICI values ( p < 0.0001), as did compound ratio ( p < 0.0001), indicating that both the identity of the combination and the dosage ratio influenced the degree of synergism.
highly significantP < 0.00010.0× alphaqualifiedgold
For ACRG subclusters, 67.2% (43/64) of MSI and 73.3% (33/45) of MSS/EMT tumours corresponded to the EMT subgroup, whereas 69.0% (49/71) of MSS/TP53+ tumours associated with metabolism subgroup, contributing to a highly significant statistical correlation between our kinase signature and ACRG subtyping (P < 0.0001; Chi-square test; Table S5 , Fig. 5 E), although no ACRG subgroup exactly matched one of our kinase-defined subgroups.