The clustering analysis based on network proteins showing increased levels in the NPM1-Ins patients showed that all except one of the patients with NPM1-Ins clustered together in the same main patient cluster, characterized by generally high levels of these proteins ( Figure 3 ); this difference in distribution of NPM1-Ins patients between the two main patient clusters is highly significant (Fisher’s exact test, p = 0.0002).
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It was found that 90% of patients had a highly significant decrease in MO on immediate postoperative period ( P = 0.0002).
[22] demonstrated that there was a significant trend for increased folate intake to be associated with a lower risk of lung cancer in men (P = 0.0002), and the multivariate RR for the participants with tertile 3 folate intake was 0.70 (95% CI, 0.55–0.89) when compared to those with tertile 1 folate intake.
We observed a highly significant and highly variable F IS ( F IS = 0.285, p -value > 0.0002, 95% CI = [-0.021, 0.261]) ( Fig 3 ).
Secondary transplantations performed using tumour cells from two recipient animals demonstrated a highly significant reduction in disease latency (median 48 vs 132 days, p=0.0002) in keeping with evolution of the B220 + /Mac1 Int population to frankly malignant cells ( Figure 3e ).
9 , bottom row); these differences were significant for all groups including the LVS Δ capB vector in experiment 1 (ranging between P < 0.05 to P < 0.01) and for all but the parental vector and one vaccine in experiment 2 (ranging from P < 0.05 to P < 0.0001); combining all LVS Δ capB and r LVS Δ capB /Bp vaccines, the increase in antibody to HI Bp82 was highly significant ( P = 0.0002 and P < 0.0001 by two-tailed t test in experiments 1 and 2, respectively).
Seasonal trends reveal that most of the patients visited for consultation in the beginning of the year, with a highly significant number of cases presenting in March and April clubbed together [P value = 0.0002] with 63% of the visits occurring from February to June ( Figure 3 ).
The size of this effect was reflected in a highly significant group-level difference between Probe and Irrelevant (P3a-Fz: t (11) = 5.57, p <.0002; d = 1.61.
There was a highly significant difference of the mean internal carpal tunnel ratio between male patients and controls (male patients: 0.42 ± 0.05; male controls: 0.34 ± 0.04, P = 0.0002) as well as between female patients and controls (female patients: 0.39 ± 0.06; female controls: 0.35 ± 0.04, P = 0.034). 3.1.2.
However, we did find a highly significant increase in the rare/common CNV ratio in the LFS patients carrying mutations in the TP53 DBD when compared to both controls (p=0.0002) and to patients carrying the p.R337H mutation (p=0.0156; Fisher-exact test) (Figure 1B ).
The nonlinear SUA–PSE association was preserved (P for nonlinearity < 0.001), and the nonlinear sex × SUA interaction component remained highly significant ( p = 0.0002), confirming that the sex‐dependent pattern is not attributable to severe‐stroke cases.
The chi-square test for heterogeneity was highly significant ( P = 0.0002), indicating substantial difference between the individual trials results.
For instance, the genus Clostridium exhibited the highest mean relative abundance in the high Ca treatment (V), with highly significant differences ( p = 0.0002) compared to the control (K) and most other treatments.
Correlations computed within each group further strengthen the distinct AD vs HC responses, showing a clear trend within the former group (Spearman rho < −0.92, p < 0.0002, FDR < 0.003, n = 10) but no statistically significant relationship in the latter (Spearman rho = 0.39, p > 0.38, FDR > 0.38, n = 7).
A highly significant statistical correlation between WGA fluorescence and degree of dysplasia was found ( P = 0.0002), with areas of high grade dysplasia and cancer showing lower fluorescence intensity and WGA binding relative to areas of nondysplastic Barrett’s esophagus and normal esophageal mucosa.
For females, this resulted in highly significant subspecies divergence in contact (t 55 = −4.19, P = 0.0002) but not allopatric samples (t 18 = −0.14, P = 0.89).
Furthermore, the overall staining quality analysis, which compared Poor, Good, and Better grades, showed a highly significant difference (χ 2 = 16.87, P = 0.0002), further confirming the enhanced performance of the H&K technique, as shown in Table 2 .
The difference between the frequency of nodal involvement in the patients without distant metastases (21.5%) and those with metastases to an osseous (39.0%) or visceral site (50.9%) was highly significant ( P = 0.0002); that between those whose first distant metastasis was to the viscera and bone was not statistically significant ( P = 0.249).
These curves clearly show that while thirds of IL-6 showed little discriminative ability in separating risk for nonfatal CVD in unadjusted models ( p = 0.13), associations with risk for fatal CVD events, fatal other CV events, or non-CVD mortality were all highly significant ( p ≤0.0002 for all).
For overrun, sodium alginate (A) and Rügen chalk (B) exhibited highly significant effects ( p = 0.0002 and p = 0.0017, respectively).
Though this gene has been used in the literature [ 39 ], performance of this gene in our mouse panel was mediocre, and as shown in Fig 6A , the raw (non-normalized) data for B2M in our mouse muscle dataset does appear to suggest a highly significant (P = 0.0002) increase in B2M expression in dystrophic tissue.
The differences between the populations are highly significant for both Cmax values, as determined by 3-group permutation ANOVA (p < 0.0002 for both) and pairwise Wilcoxon test for sparse vs dense (p = 2e-18 and p = 9e-14 for Cmax = 90 nM and 900 nM, respectively).
The H1: TAA noncarriers showed highly significant higher average procalcitonin levels (5.1 ± 9.7 ng/dL vs. 3.5 ± 9.1 ng/dL; p = 0.0002) as well as significantly lower urine outputs (2792 ± 1242 mL/day vs. 3060 ± 1370 mL/day; p = 0.0229) over the observation period than the H1: TAA-positive patients. 4.
A highly significant (P = 0.0002) increase in the rate of malsegregation affecting structurally normal chromosomes was observed in association with Robertsonian translocations.
Both regressions were highly significant ( p -value = 0.0002 for seed viability and <0.0001 for seed counts).