Excerpts

Using a permutation test, we found that the separation in monophyly score between core and accessory genes is highly significant (p = 0.0002).

This difference was highly significant (GROUP effect: F = 21.18; P = 0.0002; Fig. 3a ) and was apparent during both the ramp and hold phases, and at both force levels (P = 0.01).

The gender difference is highly significant (t(62) = 3.83, p < 0.0002, two-tailed, with an effect size Cohen’s d = 1.025).

Significant increase was observed after PVAC ablation ( p =0.0313), after cryo ablation ( p =0.0039), and a highly significant increase occurred after IRF ablations ( p =0.0002; Figure 4 ).

When the tumour volumes at day 4 post-treatment were compared to untreated tumour volumes at day 4, there were highly significant differences (p < 0.0002) at all doses (Table 1 ).

2C ), the reduction in non-NAb binding to the cross-linked trimers was highly significant compared to the bNAb group ( p = 0.0002, Mann-Whitney U test).

Upon quantification (Figure 6B ), this increase in mortality was highly significant ( p = 0.0002 as compared with TFN; p = 0.0089 as compared with PF477736 and p = 0.0245 as compared with camptothecin).

Furthermore, additional analyses suggested that the preferential co‐localization of PSD95 and gephyrin within the GFAP+ reactive astrocytes of prion‐infected Csf1r ΔFIRE mice was highly significant compared to the null hypothesis that the immunostaining was randomly distributed (PSD95/GFAP, P < .0002; Gephyrin/GFAP, P < 7 × 10 −5 ).

The second strongest signal identified in the GWAS, observed at rs12506228, showed two independent replications and the meta-analysis for replication studies was highly significant ( p = 2.0 × 10E-4).

This caused a highly significant (p = 0.0002) decrease in OPC viability (Fig. 1h ).

p ‐values estimated by Mantel tests were highly significant or significant at p = .0002–.009 in nine cases and marginally significant at p = .061 in one case.

coli O157:H7 was extremely significant compared to the control ( p = 0.0002), but ratios of Fura-2 with non-target bacteria weren’t found the significant differences compared to the control ( p > 0.05) in the ground beef extract samples.

To reduce the bias of time to HSCT2 we analyzed only patients having HSCT2 within 6 months of relapse and found that having HSCT2 was a highly significant predictive factor in this univariate analysis ( P =0.0002).

Results and Discussion Metabolites and isotopic signatures With increasing CH 3 F concentration, acetate accumulated while methane accumulation was reduced accordingly ( Figure 2A ) resulting in a highly significant negative correlation (r = 0.7, P = 0.0002).

7 Here, at 13 months posttreatment, BST-CarGel treatment resulted in a highly significant improvement ( P = 0.0002) compared with MFx alone in the total macroscopic score, which encompasses the assessment of lesion fill, integration to native cartilage, and surface quality of the repair tissue.

The rs748096191 genotype also showed significant association with LDL, and non-HDL cholesterol levels and borderline significant association with total cholesterol level after Bonferroni correction ( p = 2.00 × 10 −4 , p = 2.68 × 10 −4 , and p = 8.20 × 10 −4 , respectively).

The Ctn reference ranges determined in this way for patients with nodular thyroid findings (90% confidence intervals) were <3.0 to 9.1 pg/mL for women and <3.0 to 14.1 pg/mL for men, i.e., very similar to the reference ranges specified by the manufacturer and with a highly significant sex difference ( p < 0.0002).

However, when we pooled data for each continental group and compared the sub-Saharan component across all genomes within that group with the estimated Neanderthal ancestry in the same genomes, we found a highly significant negative correlation for Western Asia (rho=−0.234, P < 0.0002; supplementary table S2 , Supplementary Material online).

Indeed there is a highly significant correlation between urinary glucose and the glucose tolerance test area under the curve (r=0.623, p=0.0002), a measure of insulin resistance not directly influenced by food intake.

However, when the cells were irra- diated, the slopes of the dose response for S2 and S3 cells were about twice that of F9 cells, indicating that MN fre- quencies after X-irradiation were consistently higher in cells overexpressing the bcl-2 gene and the differences were highly significant at the dose point of 4 Gy (P= 0.0002-0.002).

The amount of FD4 diffusing through the monolayer (measured by the permeability coefficient, P app ) treated with TGFβ3 was about 10fold higher (highly significant, p = 0.0002) compared to an untreated monolayer ( Fig. 2 ).

Similar to mid-term mortality, subgroup analysis showed that LVEF improvement was quite significant in levosimendan vs. placebo subgroups (mean difference: 5.65%, 95%CI: 2.72–8.57%, P=0.0002, I 2 =33%) ( Figure 4 ).

We performed qPCR analysis to detect the expression of AKAP12α and AKAP12β isoforms using isoform-specific primer sets and found less significant reduction in AKAP12β gene expression in tumor tissues (P=0.0594), whereas the reduction in the expression of AKAP12α gene in tumors was highly significant (P=0.0002) ( Fig. 1B ).

In contrast, the reduction in leukocyte counts was highly significant (P = 0.0002, F = 6.11) at the 0.05 level.

At the household level, out of 306 HH visited, 40 HH had at least one positive animal (13.07%) and the p value between HH in the two states was highly significant ( p = 0.0002).