Excerpts

Comparison of the co-expression profile of CHRNA5 expression across 59 CCLE breast cancer cell lines with the logFC values from CHRNA5 RNAi profile revealed a highly significant negative correlation and association (r = -0.33, p = 3.8E-48).

Error t value Pr(>|t|) topME $ logFC -0.738 0.0472 -15.7 6.17e-48 > abline (RNAvsME, col = "red" , lwd = 2 ) The negative association is highly significant ( P = 6 × 10 − 48 ).

In addition, allele frequencies derived from the pooled sequencing experiment were compared to those derived from all individuals in the phase II genotype data and revealed a highly significant correlation (r = 0.971, p < 6.58x10 −48 ), further supporting the validity of the pooled sequencing approach.

When restricted to the 3,137 EUR cases with a PheCode probability >0.80 and their 12,548 matched controls, the 90-SNP weighted PRS was highly significant (odds ratio [OR] = 1.82 [95% confidence interval: 1.68–1.97]; p = 8.0 x 10 −48 ).

As it turned out, there is a highly significant association between induction in both systems (Fisher’s exact test p value = 1.3, 10–47).

A statistical comparison using Cochran's Q test revealed highly significant differences among the models (Q = 235.5, df = 7, p = 3.27E-47).

Meder also found a highly significant association between their lead-SNP rs9262636 and HLA-C mRNA levels ( p = 4.05 × 10 –47 ) ( Meder et al., 2014 ).

This 2.76-fold enrichment in this case is highly significant, with a Fisher exact test p = 8.20 × 10 −47 .

When we test the association of each PC with ER status, PC1 scores have a highly significant association with ER status ( p < 10 −46 , Wilcoxon rank-sum test), whereas PC2 and PC3 are less associated (Fig. 2 b).

With a global average of 52.7% ± 0.12% history-congruent trials, we found a small but highly significant perceptual bias towards preceding experiences ( β = 16.18 ± 1.07, T(1.09×10 3 ) = 15.07, p = 10 −46 ; Fig 2A ) that was largely consistent across studies ( S1B Fig ) and more pronounced in participants who were less sensitive to external sensory information ( S1C Fig ).

There was a highly significant improvement in the cCBL students’ exam marks for the questions particularly on myocardial infarction (MI; p = 2.2E-46 , Fig. 2 A), but also on chronic kidney disease (CKD; p = 0.0012 , Fig. 2 B) and diabetes ( p = 0.022 ; Fig. 2 C).

The libraries M19 and M25 have 0,985 as correlation coefficient and have a highly significant regression (P = 2,31 × 10 -46 , after Bonferroni correction P = 7,49 × 10 -43 ).

Circulating T cell fraction remained highly significant after adjusting for clinical factors in the pan-cancer cohort (Fig. 5b (HR = 0.76, P = 2.6 × 10 −46 ) and Extended Data Fig. 9a ) and within five individual cancer types after multiple hypothesis correction—head and neck squamous cell carcinoma (HR = 0.70, adjusted P = 4.68 × 10 −2 ), pancreatic adenocarcinoma (HR = 0.74, adjusted P = 4.81 × 10 −2 ), colon adenocarcinoma (HR = 0.85, adjusted P = 1.12 × 10 − 2 ), lung adenocarcinoma (HR = 0.80, adjusted P = 5.4 × 10 −3 ) and sarcoma (HR = 0.68, adjusted P = 1.57 × 10 −4 ).

A highly significant association was observed between BMI and triglyceride levels (Beta = 0.26, p = 3.06E-46), and a positive correlation trend was also seen between BMI and UA.

According to GeneAtlas, FYCO1 variant rs33910087 is a highly significant modifier of monocyte percentage ( p = 3.85 × 10 −46 ), and based on GTEx v8, this variant is also an eQTL for several protein-coding genes previously associated with COVID-19 ( CXCR6 , FYCO1 , SLC6A20 , CCR1 , LZTFL1 ).

These represent 41% and 33% of upregulated phosphoproteins in OCMI91s and OVCAR8 cells, respectively - a highly significant overlap by hypergeometric test (enrichment 3.0-fold; p = 4x10 -46 ).

Paf1 exhibited highly significant enrichment around the TAD boundaries (p = 4.8E-46) but not replication origins (Figs 7C and S6B ).

The ANN achieved an F-statistic value of 432.7, indicating a highly significant model fit with a practically negligible probability of F-statistic ( p < 6.06 × 10 −46 ).

5 E) demonstrates highly significant segregation of GBMs and LGGs ( P <10 –45 , odds ratio=28, Fisher exact test) supporting that YAP activation is a hallmark of malignant brain cancer and suggesting that this eight-gene signature might provide sufficient information to distinguish high-grade from low-grade gliomas.

The two conditions shared a highly significant ( P < 10 −45 , hypergeometric test) overlap of 741 genes ( Fig. 5 B ).

In agreement with this, when restricting the analyses to Trans- CDS, ABO is still highly significant ( p = 1.18 × 10 −45 ), in contrast to OBP2B where the p -value drops dramatically ( p = 2.49 × 10 −13 ).

Of note, a highly significant association (− log 10 P = 44.79) for ‘seed: colouration with phenol’ on chromosome 2A was just 0.37 Mb from the Ppo-A1 gene known to control discolouration in wheat food products.

Three transcription factors were highly significant; MYCN (p-value = 1.71E-45), MYC (p-value = 1.11E-11) and NFE2L2 (p-value = 5.97E-17) during this analysis.

Analysis using the GEPIA database revealed a highly significant correlation ( p = 2e -45 , R = 0.82) between these markers, providing new insights into the molecular mechanisms underlying PAAD progression and identifying new targets for diagnostic and therapeutic strategies.

In contrast, within-tumor tests of total K14 were highly significant ( p = 2 × 10 −45 , Fig 9B ).