Excerpts

T CM /T EM ratio has been used to reflect the differentiation status of T cells ( 38 ), We therefore compared this parameter before and after GC treatment and found a highly significant increase ( P = 0.0004) of the T CM /T EM ratio among CD8 + T cells after GC treatment ( Figure 7C ).

This difference was highly significant ( P = 0.0004); the average distributions were 64% ±17 gametocytes in the BM and 8% ±9 gametocytes in the PB (Fig. 3b ).

In the jejunum, both buprenorphine and tramadol caused a highly significant decrease in MPO activity in comparison with chemotherapy-treated control animals (53%, p = 0.0004 and 58%, p = 0.0001 respectively, Fig 2A ).

However, differential abundance analysis showed a trend toward increased Bifidobacterium in the SCF group compared to placebo (ANCOM-BC p = 0.0004, FDR q = 0.073).

Responses to the QuickDASH instrument in each study group expressed highly significant values ( p < 0.0004 and p < 0.0001) in each of the QuickDASH assessment sessions.

There was a highly significant difference in the total uptake at t = 114 h (p = 4 × 10 −4 ) and t = 234 h (p = 3 × 10 −3 ), confirming that the rate of uptake of the A10.1 accession was greater than that of the Ast-1 accession.

At the end of 12 weeks, there was a highly significant ( P = 0.0004) 20 m placebo-corrected median improvement in 6MWD.

While the deletion of Grk1 slowed the recovery of responses driven by both pigments, the effect on the M-pigment response was much larger; thus, in the absence of Grk1, the average Δ T 50 of the response to the M-pigment increased 7.5-fold (from 0.33 to 2.44 s), while the Δ T 50 of the UV-pigment response increased 2.8-fold (from 0.25 to 0.69 s); both these differences in Δ T 50 are highly significant (P < 0.0004), arguing strongly that Grk1 is necessary for normal inactivation of both pigments.

Dogs receiving polytherapy have a highly significant increase in shaking, shivering, or trembling when left or are about to be left on their own when compared to dogs on monotherapy (question 22, P = 0.0004).

A meta-analysis in 2002, which used data from 18 trials and 2074 patients, indicated a highly significant reduction in the risk of death with NACT (HR 0.65, 95% CI 0.53–0.80, P = 0.0004) [ 14 ].

Self-reported engagement in muscle-strengthening exercise showed a similar pattern, with highly significant differences at all three follow-up times (p=0·0004, p=0·0004, and p=0·0006).

The overall comparison between lesion types was highly significant (χ 2 = 15.8, p = 0.0004), and Fisher's exact test again confirmed significantly worse external rotation outcomes in the CP group compared with all other lesions combined (p = 0.0012).

CfMYB2 (Figure 4E ): A significant main effect of both cultivar ( F = 10.04, p = 0.0012) and stage ( F = 5.21, p = 0.0164), as well as a highly significant cultivar × stage interaction ( F = 8.79, p = 0.0004), was observed for CfMYB2 expression.

FCS (supplemented normal growth medium) led to a highly significant increase in COL1 expression compared to CPRP-treated cells ( p = 0.0004), which showed a decreased expression of COL1 compared to growing cells calculated by simple ANOVA with Tukey’s multiple comparison tests.

Interestingly, however, there was a highly significant positive correlation between MDA and HMGB1 in the liver flush ( r = 0.9763, P = 0.0004) ( Figure 8C ).

In control subjects, the data further revealed substantial and highly significant reductions in axial stiffness (3.9% and 4.0%, p = .0004 and .001 at 12 and 24 months, respectively) at the tibia and 3.6% and 3.7% ( p = .002 and .03) at the radius at the two time points.

We found that our decoder predicted the correct CA3 input pattern 71.4% of the time, which was highly significant compared to a shuffle distribution where CA3 input labels were randomly assigned (Figure 6e ; p = 0.0004; bootstrap test).

For generosity we found highly significant correlations with total T (r = −0.25, two-tailed t test, N = 200 for this and subsequent tests, p = 0.0004), free T (r = −0.1908, p = 0.0068), and DHT (r = −0.3063, p = 0.0001); see Fig. 4A .

After adjustment for confounders, apoJ at baseline and at 18 months was marginally significant after adjustment for multiple comparisons ( P = .0004).

The levels of VLDLR-AS1 were lower in the rmTBI samples compared to the no lifetime TBI samples, and this difference was highly significant ( p = 0.0004), indicating that VLDLR-AS1 is a strong, viable indicator of rmTBI.

The PCC for H10 results was 0.52, but also highly significant ( P <0.0004).

9.3 days (COVID), showing a 71% decrease in overall hospital stay; this was statistically highly significant (p = 0.0004).

Using a paired Student's t-test, the difference is highly significant (p = 0.0004).

The spatial cross correlations between the HCP task networks and Smith’s BrainMap networks ranged from r = 0.26–0.74, with the minimum r = 0.26 being highly significant (p = 4 × 10 −4 , corrected).

The differences were statistically highly significant ( P = 0.0004).