Excerpts

Conversely, a highly significant correlation was observed between steroidogenic efficacy and RT (Pearson r = 0.8526; P = 0.0004; r 2 = 0.7270) ( Fig. 5D ).

The masculinization approached significance (p-value = 4E-4) in 5 wk old Trim24-null mice vs. wild-type mice from the same study ( GSE19675 ).

Cu 2+ produced the most pronounced response at both pH values, with a highly significant overall effect at pH 8.0 ( F (2,6) = 39.41, p = 0.0004, η 2 = 0.93) and all pairwise comparisons remaining significant after correction ( p adj ≤0.010), consistent with robust quenching and EDTA-driven hyper-recovery.

However, differential abundance analysis showed a trend toward increased Bifidobacterium in the SCF group compared to placebo (ANCOM-BC p = 0.0004, FDR q = 0.073).

were elevated in participants receiving SCF compared to placebo, but this did not reach statistical significance after correcting for multiple comparisons ( p = 0.0004, FDR q = 0.073, ANCOMBC).

In the 4-arm variation ( Figure 1M ), the group effect was very significant [ F (2,230) = 5.822, p = 0.0034] and the trial # effect was extremely significant [ F (9,230) = 3.552, p = 0.0004].

As shown in Figure 4 B, those patients with score 2 showed a highly significant poorer survival than those patients with score 0 or 1 in the Kaplan–Meier analysis ( p = 0.0004 and p = 0.0040, respectively).

After adjustment for confounders, apoJ at baseline and at 18 months was marginally significant after adjustment for multiple comparisons ( P = .0004).

However, several lines of evidence point to an effect of the lower dose on exercise endurance: (i) tiotropium/olodaterol 2.5/5 μg significantly improved EET during CWRCE compared with placebo in both MORACTO ® studies [26.5% ( p < 0.0001) and 12.1% ( p = 0.0003)]; (ii) there was a nominally significant improvement in EET during CWRCE after 6 weeks (22.1%, nominal p = 0.0004) in the present study; (iii) in post hoc analysis, change from baseline in EET during CWRCE after 6 and 12 weeks was nominally significant.

In the final training session, she spent an average of 23 ± 3 s to complete each drawing, which is a highly significant improvement over the first training session ( p < 0.0004; t = 4.32; df = 19).

These differences were statistically highly significant (Figure 4 A, t = -3.59, P = 0.0004; Figure 4 B, t = -2.59, P = 0.01; see “seedling survival”).

AA) further supported this finding, showing a highly significant risk elevation (OR = 2.85, P = 0.0004), and the MTHFR C allele itself exhibited the strongest allelic association observed (OR = 2.17, P = 0.0004).

In temporal GM, the overall association between normalised S1P level and Braak stage was highly significant (p = 0.0004).

This difference in uptake between [ 18 F]-FACBC and [ 18 F]-FET was highly significant for the MM.1S ev/ev xenograft tumors ( p = 0.0004).

The association was found to be statistically highly significant (p = 0.0004).

In comparison, only 4 of 19 (21%) CD14-KO mice developed symptoms of ECM indicating that loss of CD14 confers a highly significant protection from ECM (p<0.0004, Fisher's exact test).

Imaging findings There was a highly significant difference between both groups in the context of lung congestion in X-ray with more congestion profile in COVID-19 patients ( p = 0.0004).

Regression analysis using BMI as an ordered categorical variable revealed highly significant differences in the effect of PNPLA3 genotype on HTGC among the 4 BMI groups (t-test; P=0.0004).

Adrenalectomized male mice 6 hr after injection with another GR agonist (dexamethasone) (1 mg/kg) approached significance for feminization (p-value = 4E-4) ( GSE24256 ).

The Karolinska Sleepiness score significantly decreased after the nap-chair rest, and the between-treatment difference in the decrease was highly significant ( P = 0.0004).

We observed a tendency to flux increase with 100 μM berberine incubation for 6 h (2.72 nmol/cm2/h, IQR: 1.98–3.31, p = 0.07) and a highly significant effect with 200 μM berberine (9.54 nmol/cm2/h, IQR: 6.6–13.56, p = 0.0004).

The pivot shift test emerged as the strongest predictor of surgeon agreement, showing highly significant results ( p = 0.0004).

Mirtazapine was also a highly significant suppressor of the histamine response when evaluating median wheal size for monotherapy compared to controls ( p = 0.0004) (Table 3 ).

These groups demonstrated highly significant improvements in OS (Bm2 hi /CCL3 lo HR = 0.14 (95%CI:0.04–0.49) p = 0.0004; Bm2 hi /CCL4 lo HR = 0.21 (95%CI:0.08–0.57), p = 0.001; and Bm2 hi /CXCL8 lo HR = 0.29 (95%CI:0.11–0.76), p = 0.007, Figure 5 ).

After multiple comparison adjustment, miR-519a-3p remained significantly correlated with VO 2 peak ( P = .0001, FDR = 0.046, and r = 0.5) and miR-18a-3p showed marginal significance and correlation ( P = .0004, FDR = 0.092, and r = 0.4).