Excerpts

The difference in degree of nucleotide conservation between the IDR and the remainder of the molecule is highly significant ( P <10 −16 ), and indicates a dramatically higher level of divergence for the IDR-encoding portion of the mammalian TS transcript.

All were highly significant ( p < 10 –16 for all chromosomes after Bonferroni correction), with over 96% of the variation in the F5 position being explained by the F2 position for every chromosome tested ( Figure 2 ).

The correlation is weakly negative ( R S = −0.18) but highly significant ( p <10 −16 ) because the number of points is so large.

We observed a strong (Pearson correlation coefficient of r = 0.98) and highly significant ( p < 10 −16 ) linear relationship between the number of infected individuals N ( t ) and the method’s incidence correlate φ ( t ).

Next-generation sequencing in pooled samples from patients with Crohn's disease and controls identified additional independent risk variants in two of the known risk genes ( NOD2 and IL23R ), a highly significant association with a protective splice variant in CARD9 ( P < 1 × 10 −16 , odds ratio ∼0.29), and additional associations with coding variants in several genes ( IL18RAP , CUL2 , C1orf106 , PTPN22 and MUC19 ) ( Rivas et al. , 2011 ).

We also created protein interaction networks of non-plaque tissue DS, EOAD, and LOAD proteomes, which showed a highly significant degree of protein–protein interactions (PPI enrichment p = 1 × 10 −16 , Supp.

The constructed PPIN comprised 44 molecular nodes interconnected by 296 edges, demonstrating highly significant interaction enrichment ( p = 1.0e-16).

In spite of different cell death phenotypes of these mutants, RNA-seq revealed that all three mutants down-regulated the same 95 genes and up-regulated the same 9 genes, a highly significant portion of the total transcriptome (p<10 −16 ) ( Figure 5 and Table S5 ).

The highly significant protein–protein interaction network ( p < 1.0E-16) was created with 378 nodes, 810 edges, 4.29 average node degree, and 0.357 average local clustering coefficient ( Figure 13A ).

All constructed PPI networks exhibited highly significant enrichment (PPI enrichment p -value < 1.0 × 10 −16 ), suggesting that the observed number of interactions is greater than expected by chance.

STRING analysis revealed highly significant connectivity between almost all input genes (enrichment p -value < 1 × 10 −16 ), suggesting that TCF19 may be regulating one cluster of interconnected genes ( Figure 2 B).

Starting with the GO gene sets, we found a highly significant enrichment in genes related to the innate immune response particularly (p = 1.×10 −16 , FDR = 1.36 × 10 −12 ).

However, the overlap between the two categories of the intergenic transcribed regions is highly significant (P-value < 10 -16 , chi-square test)." Contributor Information Philipp Kapranov, Email: philippk08@gmail.com.

To validate the biological significance of this manually compiled pathway, we applied STRING protein–protein interaction enrichment analysis, which confirmed highly significant interaction for the RORC consensus pathway (expected number of edges: 11, observed number of edges: 83, enrichment p < 10 −16 ).

Of these, 1495 genes are detectably expressed in our lines, and 1079 (72.2%) are classified as DE between the species in both data sets (a highly significant enrichment; χ 2 p < 10 −16 ).

Consistent with this structure, the STRING PPI enrichment analysis was highly significant (p < 1 × 10 −16 ), supporting the conclusion that these proteins form a biologically coherent interaction network rather than a random assembly ( Figure 9 ).

The network displayed an average clustering coefficient of 0.604 and a highly significant PPI enrichment ( p < 1.0 × 10−16), indicating substantial functional connectivity among the proteins.

STRING analysis reveals a highly significant clustering ( p = 1 × 10 −16 ) of over 90% of the proteins identified ( Figure 7 ), with the existence of sub-clusters related to ER protein quality control, mitochondria membrane protein translocation, nuclear import, and stress granules.

One-way analysis of variance (ANOVA) using the cluster size as the factor variable found that both results are highly significant ( P < 10 −16 ).

The heritability estimates for all subfields, displayed on the plot’s diagonal, were highly significant (all p -values < 1 × 10 −16 ), ranging from h 2 = 0.14 of the parasubiculum to h 2 = 0.27 for the hippocampal tail.

In Silangit, the most discriminative metabolites were tromethamine, oxalacetic acid, adenosine, phenylacetaldehyde, and bis(2-ethylhexyl) phthalate, all of which showed highly significant differences ( p < 1.0 × 10 −16 ).

Cruise-specific calibrations of shipboard fluorometers, nephelometer/optical backscatter, and oxygen sensors yielded highly significant ( P <10 −16 ) linear relationships between all discrete and calculated concentrations of chlorophyll- a , SPM and DO ( Fig. 3 ).

We have applied a statistical test and found that all of the comparisons of short gene expression to longer gene expression are highly significant (p-values <10-16, Kolmogorov-Smirnov test).

This detrimental effect of antibiotics was highly significant among the phyla Bacteroidota and Firmicutes_A (p < 1e–16, OR 0.7) and observed at various host ages ( Figure S2 E).

The overall PPI enrichment was highly significant ( p -value < 1.0e-16).