Excerpts

Twenty-four GST peptide isoforms were identified under seven different classes with a highly significant protein-protein interaction between GST groups and within other detoxification metabolism-related peptides ( p -value < 1.0 × 10 −16 ).

For a random protein set of comparable size, the expected number of edges was 8, whereas the observed network contained 44 interactions, resulting in a highly significant PPI enrichment p -value < 1.0 × 10 −16 .

There is a highly significant correlation between F ST and A ancestry difference between the lowland and highland samples (Spearman's ρ = 0.26, P < 10 −16 ).

Notably, only proteins associated with our list of cKO- Eed -MADM–specific DEGs, but not sparse Eed -MADM–specific DEGs, formed a highly significant and densely connected network (PPI enrichment P value < 1 × 10 −16 ) (fig.

The correlation between the distance of GO groups in the 0.001 cutoff co-evolution network (that is, their evolutionary distance) and their distance in the corresponding GO ontology network (that is, their functional distance) is highly significant: 0.38 for cellular component, 0.16 for biological process and 0.43 for molecular function (all three with P -values <10 -16 ; a similar trend is observed using the 0.01 cutoff network).

41 All clocks demonstrated a strong and highly significant correlation with the biologic age, with the skin and blood clock demonstrating the strongest correlation (Pearson R = .96; 95% CI, 0.959–0.97; P <1 × 10 16 ) ( Figure 8 A ).

The resulting network showed a highly significant interaction among the proteins (p value < 1.0e −16 ).

The network displayed an average target degree of 4.97 and a local clustering coefficient of 0.514, indicating a highly significant PPI enrichment (p-value <1.0e-16).

By enhancing the confidence levels of the PPI to the highest level (0.9), the number of edges decreased to 2534 and the node degree average to 8.11, but the PPI enrichment remained highly significant ( p < 1.0 × 10 −16 ), underscoring the quality of the proteomic data.

This detrimental effect of antibiotics was highly significant among the phyla Bacteroidota and Firmicutes_A (p < 1e–16, OR 0.7) and observed at various host ages ( Figure S2 E).

Figure 4 puts the predicted ratios in the context of the training ratios, and Table S8 of the Supporting Information quantifies their correlations, elucidating a variety of trends: (1) no_resampling shows a positive trend between the training and the predicted ratio (Pearson’s r 95% CI: [0.440, 0.496], p < 10 –16 ), but since the training and the test ratio are also positively correlated ( Figure 3 ), the latter could be the one driving the predicted ratio of positives; (2) resampling_after_clustering had a constant

All constructed PPI networks exhibited highly significant enrichment (PPI enrichment p -value < 1.0 × 10 −16 ), suggesting that the observed number of interactions is greater than expected by chance.

The constructed PPIN comprised 44 molecular nodes interconnected by 296 edges, demonstrating highly significant interaction enrichment ( p = 1.0e-16).

Using STRING analyses, we identified a highly significant protein–protein interaction (PPI) enrichment ( P = 10 −16 ) only for the downregulated genes of H2A.Z.1‐depleted cells.

The difference in degree of nucleotide conservation between the IDR and the remainder of the molecule is highly significant ( P <10 −16 ), and indicates a dramatically higher level of divergence for the IDR-encoding portion of the mammalian TS transcript.

The overall PPI enrichment was highly significant ( p -value < 1.0e-16).

As reported in the Results section, the resulting network showed a highly significant protein–protein interaction enrichment ( p -value = 1 × 10−16), indicating that the observed interactions are far more frequent than expected for a random set of proteins of comparable size.

Again, the correlation between the P values of the 1000 top variants for the classical and mixed-effect Cox models was highly significant ( r = 0.97, Spearman P value < 10 −16 (Supplementary Fig. 4b )).

All were highly significant ( p < 10 –16 for all chromosomes after Bonferroni correction), with over 96% of the variation in the F5 position being explained by the F2 position for every chromosome tested ( Figure 2 ).

The C > A mutations observed were associated with highly significant sequence-selectivity, being marked by an excess at CpCpT (NGCII082, odds ratio (OR) = 3.2, P -value < 10 -16 , χ 2 test) or TpCpA sites (NGCII092, OR = 1.7, P -value < 10 -16 , χ 2 test) and extensions of these motifs (Materials and methods; Note 6 and Figure S6 in Additional file 1 and Table S14 in Additional file 6 ).

They were not identical to the ones identified in each disease individually, but showed a highly significant overlap in both cases ( p < 1E−16, χ 2 -test).

The heritability estimates for all subfields, displayed on the plot’s diagonal, were highly significant (all p -values < 1 × 10 −16 ), ranging from h 2 = 0.14 of the parasubiculum to h 2 = 0.27 for the hippocampal tail.

Interaction network and functional enrichment of differentially abundant proteins The interaction network between the DAPs was highly significant (p-value < 10 −16 ), indicating that the DAPs are at least partially biologically connected (Fig. 2 ).

We also created protein interaction networks of non-plaque tissue DS, EOAD, and LOAD proteomes, which showed a highly significant degree of protein–protein interactions (PPI enrichment p = 1 × 10 −16 , Supp.

The Moschus –VRTI network comprised 71 nodes and 547 edges, with a highly significant PPI enrichment p -value < 1.0 × 10 −16 .