Excerpts

While the differential signal covered the entire Cry1 locus , the largest difference was localized—peaking 26 kb downstream from the TSS in the first Cry1 intron—and highly significant ( P < 5.5 × 10 −17 at the peak) ( Fig. 1 B, bottom tracks, vertical dotted line at the left).

While no pathways were identified as over-represented in the HeH and dic(9;20) subtypes, a highly significant association ( P = 5.7 × 10 −17 , after correction) was found with neuroactive ligand-receptor interaction in the TCF3-PBX1 subtype (online supplementary Table 2 ).

The model exhibited a highly significant statistical relationship ( p = 6.483 × 10 −17 ) and moderate correlation ( r = 0.67), indicating that days with higher emissions were consistently associated with elevated surface PM2.5.

Given the highly significant positive association (Spearman’s 0.64, p = 6.5 × 10 −17 ) between hip BMDs and body mass index (BMI) (Supplementary Fig. 2 ); and other BMI-correlated physical parameters, including body weight and waist circumference in this population, we performed additional analyses on the two subgroups based on BMI: 82 lean women with normal BMI (18.5–24.9 kg m −2 ), and 51 obese women with higher BMI (≥25.0 kg m −2 ).

The Chi-square test of independence disclosed a highly significant statistical association between molecular groups and genetic alterations (χ2-test of independence, P = 6.72 × 10 − 17 ).

We found a highly significant between-group difference in EASE total score ( t = 12.73, df = 44.95, P = 0.7 × 10 –16 , 95% CI = 15.05 to 20.71), as well as in all 5 domains, with higher EASE total scores in the Sd group than in the As/ASD group.

These distinctions are highly significant ( P = 7.07 × 10 −17 between TN and FN + FP, P = 2.07 × 10 −19 between TP and FN + FP).

All NB histopathology types (64 out of 64) were correctly assigned according to the 7-GeneSig, and the inter-rate reliability of assignments was highly significant (Kappa measure of agreement p = 7.489E-17, Table 2 ).

The increased dynamic range was highly significant across units (paired t test, P = 7.5e-17, t = -8.6, df = 442).

For each overlap, the hypergeometric test was applied, and all overlaps were found to be highly significant ( Supplemental Figure 7B ; hypergeometric test P values from proximal to distal bins, DMRs: P ≈ 7.7 × 10 –17 , P ≈ 2.5 × 10 –33 , P ≈ 1.8 × 10 –16 , P ≈ 5.1 × 10 –13 ; DARs: P ≈ 4.1 × 10 –47 , P ≈ 1.3 × 10 –64 , P ≈ 1.2 × 10 –33 , P ≈ 7.9 × 10 –36 ).

This study not only found linkage to 4q23 but also identified extremely significant associations (p = 8.0 × 10 −17 ) with variants in or near the nearby gene UGT8 , though it is not yet clear whether the causal variants driving this signal have been identified 17 .

The results for a panel of the 12 genes were in good agreement with the LongSAGE data (Table 2 ) and there was a highly significant correlation (r = 0.79, p = 8.52E-17) between the two techniques.

By contrast, the global expression pattern showed a highly significant association with post conception age (Kruskal Wallis test, p = 8.592 ×10 -17 , Fig. 1b ) demonstrating a more prominent contribution of the developmental stage to the observed changes in gene expression than differences attributed to regional variations.

The respective amino acid sequence (ERKA) was found to be highly significant and positively associated with IA-2A positivity (OR 2.15, P = 8.83 * 10 −17 ).

We also observed in the ventricle a spatial, very highly significant overlap for regions where both epigenetic marks decreased ( p < 9x10 −17 ).

This difference between MS patients and non-MS controls is highly significant ( p < 10 − 16 ) .

The interaction between fingertip ROI and stimulation condition was highly significant ( F 16,80 = 71.7, P < 10 −16 , Greenhouse‐Geisser correction: F 1,5 = 71.7, P < 10 −3 ).

DAPs Are Involved in Wound Repair and Blood Coagulation Are Associated with Hydration Protein–protein interaction analyses of DAPs using STRING [ 19 ] resulted in a highly significant clustering (PPI enrichment value of p < 1.0 × 10 −16 ) consisting of 34 nodes and 126 edges ( Figure 2 ).

The network comprises 26 nodes and 131 edges, with a highly significant PPI enrichment p < 1.0e-16.

Each result is highly significant ( p < 10 −16 , for each predictor.

The resulting network comprised 78 nodes and 254 edges, exhibiting a highly significant PPI enrichment ( p < 1.0e-16, Figure 4 ).

The difference of the average log2-scaled metformin levels in blood between both groups was highly significant ( p < 10 −16 ).

Changes in mean activation magnitude in both regions between unscaled and scaled t-values are of the order of 10% of unscaled activation magnitude and are highly significant (a t-test over all voxels yields a p-value of p < 10 − 16 ).

This detrimental effect of antibiotics was highly significant among the phyla Bacteroidota and Firmicutes_A (p < 1e–16, OR 0.7) and observed at various host ages ( Figure S2 E).

All constructed PPI networks exhibited highly significant enrichment (PPI enrichment p -value < 1.0 × 10 −16 ), suggesting that the observed number of interactions is greater than expected by chance.