However, in our previous study [ 7 ] we observed a clear trend towards an improved graft survival in patients, who received a bortezomib-based treatment over a rituximab-based treatment, so that we deliberately decided to treat all upcoming patients with a bortezomib-based protocol and refrained from further trials on rituximab-based treatment in order not to expose patients to a (in our opinion) potentially higher risk of graft loss.
When comparing MSU-stimulated neutrophils treated or not with P140, a clear trend towards a higher expression of annexin A1 was observed upon P140 treatment ( Figure 4 D).
At block level, we did not observe a clear trend for left and right gaze spread.
The results of principal component analysis (PCA), as shown in Figure 10 , reveal a clear trend of separation between these two groups of samples.
There is a clear trend towards development of technologies for small molecule discovery against lncRNA targets sequestering proteins through protein-RNA interactions [ 132 ] and focusing on approaches that would deliver molecules with drug-like properties.
This study revealed a clear trend across all included reports, with ulnar allograft non-union occurring in 16% of cases and humeral allograft non-union occurring in 40%, revealing a significantly higher non-union rate among humeral reconstructions ( Table 1 ) [ 9 , 10 , 12 - 14 ].
A clear trend was observed: pigments that accumulated significantly by the end of the transient—such as Zea, Ant, Lx or α-Car in specific species and light conditions—were associated with the second, slower phase of fluorescence decrease.
While a clear trend was observed for t-score magnitudes, no clear relationship was observed between PSC magnitude and spatial smoothing.
However, evidence for such trends is conflicting 13 – 15 , probably because (i) changing vegetation communities, (ii) changing N deposition rates, or (iii) alternating dry and wet conditions with peat formation over time override a clear trend of C/N with increasing decomposition 10 .
However, there was a clear trend of increasing incident ischemic stroke associated with prior AF from 1960s to 2000 before stabilizing thereafter.
The concurrent shift toward mesh-free and domain decomposition techniques, along with the use of Bayesian optimization, highlights a clear trend toward adaptable, efficient design tools capable of operating under real-time conditions – heralding a new era of electrical machine design that is both data-efficient and physically consistent ( Asef and Vagg, 2024 ; Nyangon, 2021b ).
Updates were incorporated into the final framework when a clear trend appeared, or when researchers agreed. 3.
The data reveal a clear trend in membrane flux across the four types of salt solutions, arranged in ascending order: CaCl 2 < LiCl < NaCl < KCl.
In our culture model, we did not observe a clear trend in baseline Ca 2+ levels, or a reduction in peak amplitude or sustained levels after stimulation ( Fig 1 ).
Consider a scenario in which there is a clear trend in the work profiles generated by the two protocols such that protocol 1 always results in a nonequilibrium work profile whose largest peak is lower than the largest peaks of all work profiles generated by protocol 2.
The changes observed in fatty acids (FA) due to the lack of PRDX6 did not show a clear trend, a few monounsaturated-FA (MUFA) and PUFA increased but one MUFA and several PUFA decreased ( Table 1 ).
Although the TT genotype did not reach statistical significance, a clear trend toward increased risk was observed.
Although a clear trend in the color of the phyto-films was observed, an increase in the duration of the sonication process had significantly increased the lightness and yellowness of the phyto-films, and on the other hand, the redness of the films was drastically decreased ( p < 0.05).
Moreover, it was difficult to find a clear trend in the temperature dependence of ε c since the accuracy of estimation of ε c was lower, as described above.
A clear trend of improved wear resistance is observed with increasing TiC content, with the 15% TiC composite showing the lowest predicted wear volume across all conditions.
3.4 Center shift of plague natural foci Based on QGIS 3.34.1, an analysis of the centroids of plague risk distributions during different periods showed a clear trend of centroid migration ( Fig. 3 ).
While we cannot draw firm conclusions about the lowest charge states due to detection limitations in this m / z range, there is a clear trend in the highest charge states: as the number of Ub subunits in the covalently linked chain increases, the maximum charge state and Δ Z also increase.
The evolution of BE detection methods demonstrates a clear trend toward combining high accuracy with patient convenience.
Overall, the relationship between the intervention effort ( u ) and the precision level ( η ) for different values of α reveals a clear trend: increasing η typically requires a higher intervention effort to sustain similar levels of disease control.
The fact that we were only able to observe mild effects, lacking a clear trend, might be explained by several hypotheses.